Adriana Sampayo Reyes *

Autora invitada por SIIC

En este estudio por primera vez se muestra que el tocoferol succinato es un potente inhibidor de la hGSTO1-1.

INHIBICION DE LA GLUTATION S-TRANSFERASA OMEGA POR TOCOFEROL SUCCINATO

El tocoferol succinato es un potente inhibidor de la hGSTO 1-1. Esta investigación claramente indica que se trata de un compuesto sumamente efectivo y no tóxico para el ser humano. Los niveles de expresión de estas enzimas pueden tener significado biológico e implicaciones clínicas. Si estos inhibidores de la hGSTO1-1 resultan ser efectivos in vivo deberían realizarse más investigaciones en este contexto.

*Adriana Sampayo Reyes
describe para SIIC los aspectos relevantes de su trabajo
INHIBITION OF HUMAN GLUTATHIONE S-TRANSFERASE OMEGA BY TOCOPHEROL SUCCINATE
Institución principal de la investigación
*Centro de Investigación Biomédicas del Noreste, Monterrey, México
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Referencias bibliográficas
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Otros artículos de Adriana Sampayo Reyes

Morales Aguilera A, Jiménez Salas Z, Sampayo Reyes A. Changes in the protein profile of rats erythrocyte membranes produced by two myotonia inducers: clofibrate and anthracene-9-carboxylic acid. Biophysical Jr 1987; 51(2):568a.
Sampayo Reyes A, Morales Aguilera A, Mendoza Gamboa E. Effects of clofibrate on erythrocyte membranes. Proc West Pharmacol Soc 1991; 34:93.
Mendoza Gamboa E, Sampayo Reyes A, Morales Aguilera A. Presence of erythrocyte IgG auto-antibodies in clofibrate-treated rats. Proc West Pharmacol Soc 1991; 34:97.
Morales Aguilera A, Sampayo Reyes A. Molecular changes in erythrocyte membranes induced by long-term administration of clofibrate. European Journal of Pharmacology 1993; 245:89-95.
Bogdan GM, Sampayo Reyes A, Aposhian HV. Arsenic binding protein of mammalian systems I. Isolation of three arsenic binding proteins of rabbit liver. Toxicology 1994; 93:175-193.
Sampayo Reyes A, Morales Aguilera A. Temporal course of erythrocyte changes induced by clofibrate. Western Pharmacology Society 1995; 38:34.
Morales Aguilera A, Sampayo Reyes A, Muriel P, Favari. Biochemical changes in clofibrate modified erythrocyte membranes. Western Pharmacology Society 1995; 38:30.
Leal Garza CH, Sampayo Reyes A, Cortes EI. Estudio citogenético en parejas con aborto habitual. Antropología Biológica 1995; 3(2):29-42.
Sampayo Reyes A, Leal Garza CH, Cortes EI, Morales Aguilera A. Clofibrate induced changes in rat erythrocytes are dependent on duration of tratment. Pharmaceutical Sciences 1997; 3:407-410.
Sampayo Reyes A, Zakharyan RA, Healy SM, Aposhian VH. Monomethylarsonic acid reductase and monomethylarsonous acid hamster tissue. Chemical Research in Toxicology 2000; 13(11):1181-1186.
Zakharyan RA, Sampayo Reyes A, Healy SM, Tsapralis G, Board PG, Liebler DC, Aposhian HV. Human monomethylarsonic acid (MMAV) reductase is a member of the glutathione S-transferase superfamily. Chem Res Toxicol 2001; 14:1051-1057.
Radabaugh T, Sampayo Reyes A, Zakharyan RA, Aposhian HV. 2002. Purine nucleoside phosphorylase in the presence od dhihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalians system. Chemical Research in Toxicology 15(5):692-8.
Cortés Gutiérrez EI, Cerda Flores RM, González Ramírez D, Zuniga Charles MA, Sampayo Reyes A, Martínez Lazcano S, Leal Garza CH. Mutagenic and cytotoxic effects of mercurous chloride evaluated by the micronuclei technique in vivo. Mutagenesis 2004; 19(3):203-205.
Aposhian HV, Zakharyan RA, Avram MD, Sampayo Reyes A, Wollenberg ML. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Toxicology and Applied Pharmacology 2004; 198:327-335.
Sampayo Reyes A, Saíd Fernández S, Cortés Gutiérrez EI, Cerda Flores RM, Narro Juárez A, Lozano Garza HG, González Garza MT, Martínez Rodríguez HG, Vargas Villarreal J, Mata Cárdenas BD, Morales Aguilera A. Effect of clofibric acid on desmin and vimentin content in rat myocardiocytes. International Journal of Toxicology 2006; 25:5.
Sampayo Reyes A, Zakharyan RA. Inhibition of human glutathione s-transferase omega by tocopherol succinate. Biomedicine & Pharmacotherapy 2006; 60:238-244.

Para comunicarse con Adriana Sampayo Reyes mencionar a SIIC como referencia:
adriana.sampayo@biomedicas.net

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Acerca del trabajo completo

INHIBICION DE LA GLUTATION S-TRANSFERASA OMEGA POR TOCOFEROL SUCCINATO



Autores
Adriana Sampayo Reyes¹, Robert Zakharyan²
1, Centro de Investigación Biomédicas del Noreste, Monterrey, México
2, Department of Molecular and Cellular Biology, University of Arizona, Tucson, Ari, Tucson, EE.UU., Investigador

Acceso a la fuente original
Biomedicine & Pharmacotherapy
http://www.elsevier.com/locate/biopha

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