Angel Oñate *

Autor invitado por SIIC

VACUNA ARN BASADA EN EL VIRUS SEMLIKI FOREST PARA BRUCELLA ABORTUS

Las particulas del virus Semliki Forest que transportan el ARNm de la proteína SOD Cu/Zn de Brucella abortus fueron capaces de inducir un significante nivel de protección frente al desafío con una cepa patógena.

*Angel Oñate
describe para SIIC los aspectos relevantes de su trabajo
AN RNA VACCINE BASED ON RECOMBINANT SEMLIKI FOREST VIRUS PARTICLES EXPRESSING THE CU,ZN SUPEROXIDE DISMUTASE PROTEIN OF BRUCELLA ABORTUS INDUCES PROTECTIVE IMMUNITY IN BALB/C MICE
Institución principal de la investigación
*Universidad de Concepción, Concepción, Chile, Concepción, Chile
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Otros artículos de Angel Oñate

Oñate AA, Vemulapalli R, Andrews E, Schuring GG, Boyle S, Folch H. Vaccination with live Escherichia coli expressing Brucella abortus Cu/Zn superoxide dismutase protects mice against virulent B. abortus. Infect Immun 1999; 67:986-988.

Oñate A, Andrews E, Beltran A, Eller G, Schurig G, Folch H. Frequent exposure of mice to crude Brucella abortus proteins down-regulates immune response. J Vet Med 2000; 47:677-682.

Oñate AA, Céspedes S, Cabrera A, Rivers R, González A, Munoz C, Folch H, Andrews E. A DNA vaccine encoding Cu,Zn superoxide dismutase of Brucella abortus induces protective immunity in BALB/c mice. Infect Immun 2003; 71:4857-4861.

Muñoz Montesino C, Andrews E, Rivers R, Gonzáles-Smith A, Moraga-Cid G, Folch H, Oñate A. Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4+ and CD8+ T cells. Infect Immun 2004; 72:2081-2087.

Para comunicarse con Angel Oñate mencionar a SIIC como referencia:
aonate@udec.cl

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Acerca del trabajo completo

VACUNA ARN BASADA EN EL VIRUS SEMLIKI FOREST PARA BRUCELLA ABORTUS

Título original en castellano
INMUNIDAD PROTECTORA EN RATONES BALB/c INDUCIDA POR UNA VACUNA ARN BASADA EN PARTICULAS RECOMBINANTES DEL VIRUS SEMLIKI FOREST QUE EXPRESA LA PROTEINA SUPEROXIDO DISMUTASA Cu/Zn DE Brucella abortus

Autores
Angel Oñate¹, Gabriel Donoso², Gustavo Moraga Cid³, Hugo Folch⁴, Sandra Céspedes⁵, Edila Andrews⁶
1 Immunólogo, Universidad de Concepción, Profesor Asociado
2 Bioquímico, Universidad de Concepción, Estudiante de Doctorado
3 Biólogo, Universidad de Concepción, Estudiante de Doctorado
4 Médico Veterinario, Universidad Austral de Chile, Profesor Titular
5 Biólogo Marino, Universidad de Concepción, Alumno de Doctorado
6 Tecnólogo Medico, Universidad de Concepción, Profesor Asistente

Acceso a la fuente original
Infection and Immunity
http://iai.asm.org

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