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C Romero-López *




NUEVOS ARN INHIBIDORES DE VHC OBTENIDOS POR SELECCION IN VITRO

El método de selección molecular in vitro desarrollado constituye una potente herramienta terapéutica que permite la obtención de nuevos ARN antivirales.

*C Romero-López
describe para SIIC los aspectos relevantes de su trabajo
INTERFERING WITH HEPATITIS C VIRUS IRES ACTIVITY USING RNA MOLECULES INDENTIFIED BY A NOVEL IN VITRO SELECTION METHOD
Biological Chemistry,
386(2):183-190 Feb, 2005

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Instituto de Parasitología y Biomedicina ´López-Neyra´, Granada, España
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Referencias bibliográficas
Aldaz Carroll L, Tallet B, Dausse E, Yurchenko L, Toulmé JJ. (2002). Apical loop-internal loop interactions: a new RNA-RNA recognition motif identified through in vitro selection against RNA hairpins of the hepatitis C virus mRNA. Biochemistry 41, 5883-5893.
Barroso del Jesús A, Tabler M, Berzal Herranz A. (1999). Comparative kinetic analysis of structural variants of the hairpin ribozyme reveals further potential to optimize its catalytic performance. Antisense Nucleic Acid Drug Dev 9:433-440.
Breaker RR. (1997). In vitro selection of catalytic polynucleotides. Chem Rev 97:371-390.
Bukh J, Purcell RH, Miller RH. (1992). Sequence analysis of the 5' noncoding region of hepatitis C virus. Proc Natl Acad Sci U S A 89:4942-4946.
Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. (1989). Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
Da Rocha Gomes S, Dausse E, Toulme JJ. (2004). Determinants of apical loop-internal loop RNA-RNA interactions involving the HCV IRES. BBRC 322:820-826.
Dev A, Patel K, McHutchison JG. (2004). New therapies for chronic hepatitis C virus infection. Curr Gastroenterol Rep 6:77-86.
Honda M, Beard MR, Ping LH, Lemon SM. (1999). A phylogenetically conserved stem-loop structure at the 5' border of the internal ribosome entry site of hepatitis C virus is required for cap-independent viral translation. J Virol 73:1165-1174.
Honda M, Ping LH, Rijnbrand RC, Amphlett E, Clarke B, Rowlands D, Lemon SM. (1996). Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology 222:31-42.
Inchauspe G, Abe K, Zebedee S, Nasoff M, Prince AM. (1991). Use of conserved sequences from hepatitis C virus for the detection of viral RNA in infected sera by polymerase chain reaction. Hepatology 14:595-600.
Kikuchi K, Umehara T, Fukuda K, Kuno A, Hasegawa T, Nishikawa S. (2005). A hepatitis C virus (HCV) internal ribosome entry site (IRES) domain III-IV-targeted aptamer inhibits translation by binding to an apical loop of domain IIId. Nucleic Acids Res 33:683-692.
Kikuchi K, Umehara T, Fukuda K, Hwang J, Kuno A, Hasegawa T, Nishikawa S. (2003). RNA aptamers targeted to domain II of hepatitis C virus IRES that bind to its apical loop region. J Biochem (Tokyo) 133:263-270.
Korf M, Jarczak D, Beger C, Manns MP, Kruger M. (2005). Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors. J Hepatol 43:225-234.
Lieber A, He CY, Polyak SJ, Gretch DR, Barr D, Kay MA. (1996). Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes. J Virol 70:8782-8791.
Pérez Ruiz M, Torres C, García López PA, Ruiz Extremera A, Salmerón J, Berzal Herranz A. (1997). Determination of HCV RNA concentration by direct quantitation of the products from a single RT-PCR. J Virol Methods 69:113-124.
Prabhu R, Vittal P, Yin Q, Flemington E, Garry R, Robichaux WH, Dash S. (2005). Small interfering RNA effectively inhibits protein expression and negative strand RNA synthesis from a full-length hepatitis C virus clone. J Med Virol 76:511-519.
Puerta Fernández E, Barroso del Jesús A, Romero López C, Berzal Herranz A. (2003a). HIV-1 TAR as anchoring site for optimized catalytic RNAs. Biol Chem 384:343-350.
Puerta Fernández E, Romero López C, Barroso del Jesús A, Berzal Herranz A. (2003b). Ribozymes: recent advances in the development of RNA tools. FEMS Microbiol Rev 27:75-97.
Reynolds JE, Kaminski A, Kettinen HJ, Grace K, Clarke BE, Carroll AR, Rowlands DJ, Jackson RJ. (1995). Unique features of internal initiation of hepatitis C virus RNA translation. Embo J 14:6010-6020.
Soler M, McHutchison JG, Kwoh TJ, Dorr FA, Pawlotsky JM. (2004). Virological effects of ISIS 14803, an antisense oligonucleotide inhibitor of hepatitis C virus (HCV) internal ribosome entry site (IRES), on HCV IRES in chronic hepatitis C patients and examination of the potential role of primary and secondary HCV resistance in the outcome of treatment. Antivir Ther 9:953-968.
Tallet López B, Aldaz Carroll L, Chabas S, Dausse E, Staedel C, Toulmé JJ. (2003). Antisense oligonucleotides targeted to the domain IIId of the hepatitis C virus IRES compete with 40S ribosomal subunit binding and prevent in vitro translation. Nucleic Acids Res 31:734-742.
Theissen G, Richter A, Lukacs N. (1989). Degree of biotinylation in nucleic acids estimated by a gel retardation assay. Anal Biochem 179:98-105.
Wakita T, Moradpour D, Tokushihge K, Wands JR. (1999). Antiviral effects of antisense RNA on hepatitis C virus RNA translation and expression. J Med Virol 57:217-222.
Wang TH, Rijnbrand RC, Lemon SM. (2000). Core protein-coding sequence, but not core protein, modulates the efficiency of cap-independent translation directed by the internal ribosome entry site of hepatitis C virus. J Virol 74:11347-11358.
Otros artículos de C Romero-López

Barroso del Jesús A, Puerta Fernández E, Romero López C, Berzal Herranz A. (2004). An experimental method for selecting effective target sites and designing hairpin ribozymes. Methods Mol Biol 252:313-325.

Puerta Fernández E, Barroso del Jesús A, Romero López C, Berzal Herranz A. (2003a). HIV-1 TAR as anchoring site for optimized catalytic RNAs. Biol Chem 384, 343-350.

Puerta Fernández E, Barroso del Jesús A, Romero López C, Tapia N, Martínez MA, Berzal Herranz A. (2005). Inhibition of HIV-1 replication by RNA targeted against the LTR region. Aids 19:863-870.

Puerta Fernández E, Romero López C, Barroso del Jesús A, Berzal Herranz A. (2003b). Ribozymes: recent advances in the development of RNA tools. FEMS Microbiol Rev 27:75-97.

Romero López C, Barroso del Jesús A, Puerta Fernández E, Berzal Herranz A. (2004). Design and optimization of sequence-specific hairpin ribozymes. Methods Mol Biol 252:327-338.

Romero López C, Barroso del Jesús A, Puerta Fernández E, Berzal Herranz A. (2005). Interfering with hepatitis C virus IRES activity using RNA molecules identified by a novel in vitro selection method. Biol Chem 386:183-190.

Barroso del Jesús A, Puerta Fernández E, Tapia N, Romero López C, Sánchez Luque FJ, Martínez MA, Berzal Herranz A. (2005) Inhibition of HIV-1 replication by an improved hairpin ribozyme that includes an RNA decoy. Acepted for publication.

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26 de mayo, 2005
Descripción aprobada
22 de julio, 2005
Reedición siicsalud
7 de junio, 2021

Acerca del trabajo completo
NUEVOS ARN INHIBIDORES DE VHC OBTENIDOS POR SELECCION IN VITRO

Título original en castellano
MOLECULAS DE ARN IDENTIFICADAS POR UN NUEVO METODO DE SELECCION IN VITRO QUE INTERFIEREN CON LA ACTIVIDAD DEL IRES DEL VIRUS DE LA HEPATITIS C

Autores
Cristina Romero López1, Alicia Barroso del Jesús2, Elena Puerta Fernández3, Alfredo Berzal Herranz4
1 Estudiante de Doctorado, Instituto de Parasitología y Biomedicina López Neyra, Estudiante
2 Investigadora, Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones, Investigadora Contratada
3 Investigadora, Universidad de Yale, Investigadora Posdoctoral
4 Investigador, Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones, Investigador Científico

Acceso a la fuente original
Biological Chemistry
http://dx.doi.org/10.1515/bc

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