Concepción María Aguilera *

Autora invitada por SIIC

El trabajo acalara la controversia entre el efecto de diferentes grasas insaturadas en la enfermedad cardiovascular

EL ACEITE DE OLIVA VIRGEN PROTEGE LAS LDL FRENTE A LA OXIDACION

El presente trabajo realizado en pacientes con patología vascular periférica demuestra una mejor defensa antioxidante en quienes tomaron dieta rica en aceite de oliva virgen en comparación a un enriquecimiento dietético con aceite de girasol.

*Concepción María Aguilera
describe para SIIC los aspectos relevantes de su trabajo
SUNFLOWER OIL DOES NOT PROTECT AGAINST LDL OXIDATION AS VIRGIN OLIVE OIL DOES IN PATIENTS WITH PERIPHERAL VASCULAR DISEASE
Institución principal de la investigación
*Institute Of Nutrition And Food Technology. University Of Granada, Granada, Spain, Granada, España
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Referencias bibliográficas
1. Grundy SM, Denke MA. Dietary influences on serum lipids and lipoproteins. J Lipid Res 1990; 31:1149-1172.2. Aguilera CM, Ramirez-Tortosa MC, Mesa MD, Ramirez-Tortosa CL, Gil A. Sunflower, virgin-olive and fish oils differentially affect the progression of aortic lesions in rabbits with experimental atherosclerosis. Atherosclerosis 2002; 162:335-344.3. Keys A, Menotti A, Karvonen MJ, Aravanis C, Blackburn H, Buzina R, Djordjevic BS, Dontas AS, Fidanza F, Keys MH. The diet and 15-year death rate in the seven countries study. Am J Epidemiol 1986; 124:903-915.4. Moreno JJ, Mitjavila MT. The degree of unsaturation of dietary fatty acids and the development of atherosclerosis. J Nutr Biochem 2003; 14:182-195.5. Lichtenstein AH, Ausman LM, Carrasco W, Jenner JL, Gualtieri LJ, Goldin BR, Ordovas JM, Schaefer EJ. Effects of canola, corn, and olive oils on fasting and postprandial plasma lipoproteins in humans as part of a National Cholesterol Education Program Step 2 diet. Arterioscler Thromb 1993; 13:1533-1542.6. Lusis AJ. Atherosclerosis. Nature 2000; 407:233-241.7. Parthasarathy S, Khoo JC, Miller E, Barnett J, Witztum JL, Steinberg D. Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis. Proc Natl Acad Sci U S A 1990; 87:3894-3898.8. Gaziano JM, Hatta A, Flynn M, Johnson EJ, Krinsky NI, Ridker PM, Hennekens CH, Frei B. Supplementation with beta-carotene in vivo and in vitro does not inhibit low density lipoprotein oxidation. Atherosclerosis 1995; 112:187-195.9. Gey KF. Cardiovascular disease and vitamins. Concurrent correction of 'suboptimal' plasma antioxidant levels may, as important part of 'optimal' nutrition, help to prevent early stages of cardiovascular disease and cancer, respectively. Bibl Nutr Dieta 1995:75-91.10. Gey KF, Moser UK, Jordan P, Stahelin HB, Eichholzer M, Ludin E. Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C. Am J Clin Nutr 1993; 57:787S-797S.11. Ramirez-Tortosa MC, Urbano G, Lopez-Jurado M, Nestares T, Gomez MC, Mir A, Ros E, Mataix J, Gil A. Extra-virgin olive oil increases the resistance of LDL to oxidation more than refined olive oil in free-living men with peripheral vascular disease. J Nutr 1999; 129:2177-2183.12. Ramirez-Tortosa MC, Aguilera CM, Quiles JL, Gil A. Influence of dietary lipids on lipoprotein composition and LDL Cu(2+)-induced oxidation in rabbits with experimental atherosclerosis. Biofactors 1998; 8:79-85.13. Kannel WB, Skinner JJ Jr., Schwartz MJ, Shurtleff D. Intermittent claudication. Incidence in the Framingham Study. Circulation 1970; 41:875-883.14. Mataix J, Manas M, Llopis J, Martinez-Victoria E. Alimentación y salud. Programa informático de nutrición. valencia: Asde Alimentación S.A., 2000.15. Mataix J, Manas M, Llopis J, Martinez-Victoria E. Tabla de composición de alimentos españoles. Universidad de Granada ed. Granada. Spain., 1998.16. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18:499-502.17. Riepponen P, Marniemi J, Rautaoja T. Immunoturbidimetric determination of apolipoproteins A-1 and B in serum. Scand J Clin Lab Invest 1987; 47:739-744.18. Chung BH, Wilkinson T, Geer JC, Segrest JP. Preparative and quantitative isolation of plasma lipoproteins: rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor. J Lipid Res 1980; 21:284-291.19. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-254.20. Lepage G, Roy CC. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 1986; 27:114-120.21. Jialal I, Grundy SM. Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification. J Clin Invest 1991; 87:597-601.22. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52:302-310.23. Frei B, Gaziano JM. Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation. J Lipid Res 1993; 34:2135-2145.24. Ramírez-Tortosa MC, López-Pedrosa JM, Suárez A, Ros E, Mataix J, Gil A. Olive oil- and fish oil-enriched diets modified plasma lipids and susceptibility of LDL to oxidative modification in free-living male patients with peripheral vascular disease: the Spanish Nutrition Study. Br J Nutr 1999; 82:31-39.25. Hargrove RL, Etherton TD, Pearson TA, Harrison EH, Kris-Etherton PM. Low fat and high monounsaturated fat diets decrease human low density lipoprotein oxidative susceptibility in vitro. J Nutr 2001; 131:1758-1763.26. Raatz SK, Bibus D, Thomas W, Kris-Etherton P. Total fat intake modifies plasma fatty acid composition in humans. J Nutr 2001; 131:231-234.27. De Bruin TW, Brouwer CB, Van Linde-Sibenius Trip M, Jansen H, Erkelens DW. Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil. Am J Clin Nutr 1993; 58:477-483.28. Mata P, Garrido JA, Ordovas JM, Blazquez E, Alvarez-Sala LA, Rubio MJ, Alonso R, De Oya M. Effect of dietary monounsaturated fatty acids on plasma lipoproteins and apolipoproteins in women. Am J Clin Nutr 1992; 56:77-83.29. Davidson WS, Lund-Katz S, Johnson WJ, Anantharamaiah G M, Palgunachari MN, Segrest JP, Rothblat GH, Phillips MC. The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein. J Biol Chem 1994; 269:22975-22982.30. Davidson WS, Rodrigueza WV, Lund-Katz S, Johnson WJ, Rothblat GH, Phillips MC. Effects of acceptor particle size on the efflux of cellular free cholesterol. J Biol Chem 1995; 270:17106-17113.31. Gillotte KL, Lund-Katz S, De la Llera-Moya M, Parks JS, Rudel LL, Rothblat GH, Phillips MC. Dietary modification of high density lipoprotein phospholipid and influence on cellular cholesterol efflux. J. Lipid Res. 1998; 39:2065-2075.32. Aviram M, Eias K. Dietary olive oil reduces low-density lipoprotein uptake by macrophages and decreases the susceptibility of the lipoprotein to undergo lipid peroxidation. Ann Nutr Metab 1993; 37:75-84.33. Baroni SS, Amelio M, Sangiorgi Z, Gaddi A, Battino M. Solid monounsaturated diet lowers LDL unsaturation trait and oxidisability in hypercholesterolemic (type IIb) patients. Free Radic Res 1999; 30:275-285.34. Jialal I, Grundy SM. Effect of combined supplementation with alpha-tocopherol, ascorbate, and beta carotene on low-density lipoprotein oxidation. Circulation 1993; 88:2780-2786.35. Reaven PD, Khouw A, Beltz WF, Parthasarathy S, Witztum JL. Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-carotene. Arterioscler Thromb 1993; 13:590-600.36. Visioli F, Galli C, Bornet F, Mattei A, Patelli R, Galli G, Caruso D. Olive oil phenolics are dose-dependently absorbed in humans. FEBS Lett 2000; 468:159-160.37. Bonanome A, Pagnan A, Caruso D, Toia A, Xamin A, Fedeli E, Berra B, Zamburlini A, Ursini F, Galli G. Evidence of postprandial absorption of olive oil phenols in humans. Nutr Metab Cardiovasc Dis 2000; 10: 111-120.38. Aruoma O I, Deiana M, Jenner A, Halliwell B, Kaur H, Banni S, Corongiu F P, Dessi M A, Aeschbach R. Effect of hydroxytyrosol found in extra virgin olive oil on oxidative DNA damage and on low-density lipoprotein oxidation. J. Agric. Food Chem 1998; 46:5181-5187.39. Visioli F, Bellomo G, Galli C. Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun 1998; 247:60-64.40. Visioli F, Galli C. The effect of minor constituents of olive oil on cardiovascular disease: new findings. Nutr Rev 1998; 56:142-147.

Otros artículos de Concepción María Aguilera

Uglow E, Slater S, Sala-Newby G, Aguilera-Garcia CM, Angelini G, Newby AC, George SJ. Dismantling of cadherin-mediated cell-cell contacts modulates smooth muscle cell proliferation. Circulation Research 2003, 92:1314–1321.Aguilera CM, George SJ, Johnson JL, Newby AC. “Relationship between type IV collagen degradation, metalloproteinase activity and smooth muscle cell migration and proliferation in cultured human saphenous vein”. Cardiovascular Research, 2003, 58:679-688.Aguilera CM, Mesa MD, Ramírez-Tortosa MC, Quiles JL, Gil A. Virgin olive and fish oils enhance the hepatic antioxidant defence system in atherosclerotic rabbits. Clinical Nutrition 2003, 22:379-384.Mesa MD, Aguilera CM, Ramírez-Tortosa CL, Ramírez Tortosa MC, Quiles JL, Baro L, Martínez de Victoria E, Gil A. Oral administration of a turmeric extract inhibits erythrocyte and liver microsome membrane oxidation in rabbits with experimental atherosclerosis. Nutrition 2003, 19:800-804.Quiles JL, Mesa MD, Ramírez-Tortosa CL, Aguilera CM, Battino M, Gil A, Ramírez Tortosa MC. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arteriosclerosis, Thrombosis and Vascular Biology 2002, 22:1225-1231.Aguilera CM, Ramírez Tortosa MC, Mesa MD, Ramírez-Tortosa CL, Gil A. Sunflower, virgin olive and fish oils differentially affect the progression of aortic lesions in rabbits with experimental atherosclerosis. Atherosclerosis 2002, 162:335-334.Aguilera CM, Ramirez-Tortosa MC, Mesa MD, Gil A. Efectos protectores de los ácidos grasos monoinsaturados y poliinsaturados sobre el desarrollo de la enfermedad cardiovascular, Nutrición Hospitalaria 2001, XVI:55-68.Ramirez Tortosa MC, Mesa MD, Aguilera CM, Quiles JL, Baro L, Ramirez-Tortosa CL, Martinez-Victoria E, Gil A. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effect in rabbits with experimental atherosclerosis. Atherosclerosis 1999, 147:371-378.

Para comunicarse con Concepción María Aguilera mencionar a SIIC como referencia:
caguiler@ugr.es

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Acerca del trabajo completo

EL ACEITE DE OLIVA VIRGEN PROTEGE LAS LDL FRENTE A LA OXIDACION

Título original en castellano
EL ACEITE DE GIRASOL NO PROTEGE LA LDL FRENTE A LA OXIDACION COMO LO HACE EL ACEITE DE OLIVA VIRGEN EN PACIENTES CON PATOLOGIA VASCULAR PERIFERICA

Autores
Concepción María Aguilera¹, María Dolores Mesa², María del Carmen Ramírez-Tortosa³, María Teresa Nestares⁴, Eduardo Ros⁵, Angel Gil⁶
1 Profesor, Universidad de Granada, Profesor Contratado Doctor
2 Investigador, Universidad de Granada, Investigador Contratado
3 Investigador, Universidad de Granada, Investigador Contratado
4 Investigador, Universidad de Granada, Investigador Contratado
5 Catedrático, Universidad de Granada, Catedrático
6 Catedrático, Universidad de Granada, Catedrático

Acceso a la fuente original
Clinical Nutrition
http://www.harcourt-international.com/journals/clnu/

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