Luis Alcalá Hernández *

Autor invitado por SIIC

RENTABILIDAD DIAGNOSTICA DE LAS INFECCIONES MICOBACTERIANAS DISEMINADAS MEDIANTE MEDULA OSEA Y SANGRE

Los cultivos de sangre representan un procedimiento más sensible y menos invasivo que los de médula ósea en el diagnóstico de las infecciones diseminadas causadas por MAC, especialmente cuando se utilizan para el cultivo botellas MycoF/Lytic. Sin embargo, no hay diferencias en el diagnóstico de infecciones diseminadas causadas por MTBC.

*Luis Alcalá Hernández
describe para SIIC los aspectos relevantes de su trabajo
EVALUATION OF BONE MARROW AND BLOOD CULTURES FOR THE RECOVERY OF MYCOBACTERIA IN THE DIAGNOSIS OF DISSEMINATED MYCOBACTERIAL INFECTIONS
Institución principal de la investigación
*Servicio de Microbiología y Enfermedades Infecciosas VIH. Hospital General Universitario Gregorio Marañón, Madrid, España, Madrid, España
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Referencias bibliográficas
Singh, N, Paterson DL. Mycobacterium tuberculosis infection in solid-organ transplant recipients: impact and implications for management. Clin Infect Dis 1998; 27:1266-77.Shafer, RW, Edlin BR. Tuberculosis in patients infected with human immunodeficiency virus: perspective on the past decade. Clin Infect Dis 1996; 22:683-704.Kilby, JM, Marques MB, Jaye DL, Tabereaux PB, Reddy VB, Waites KB. The yield of bone marrow biopsy and culture compared with blood culture in the evaluation of HIV-infected patients for mycobacterial and fungal infections. Am J Med 1998; 104:123-8.Kiehn, TE, Edwards FF, Brannon P, Tsang AY, Maio M, Gold JW, Whimbey E, Wong B, McClatchy JK, Armstrong D. Infections caused by Mycobacterium avium complex in immunocompromised patients: diagnosis by blood culture and fecal examination, antimicrobial susceptibility tests, and morphological and seroagglutination characteristics. J Clin Microbiol 1985; 21:168-73.Prego, V, Glatt AE, Roy V, Thelmo W, Dincsoy H, Raufman JP. Comparative yield of blood culture for fungi and mycobacteria, liver biopsy, and bone marrow biopsy in the diagnosis of fever of undetermined origin in human immunodeficiency virus-infected patients. Arch Intern Med 1990; 150:333-6.Nichols, L, Florentine B, Lewis W, Sattler F, Rarick MU, Brynes RK. Bone marrow examination for the diagnosis of mycobacterial and fungal infections in the acquired immunodeficiency syndrome. Arch Pathol Lab Med 1991; 115:1125-32.Riley, UB, Crawford S, Barrett SP, Abdalla SH. Detection of mycobacteria in bone marrow biopsy specimens taken to investigate pyrexia of unknown origin. J Clin Pathol 1995; 48:706-9.Martinez-Sanchez, L, Ruiz-Serrano J, Bouza E, Torres L, Diaz M, Alcala L, Rodriguez-Creixems M. Utility of the BACTEC Myco/F lytic medium for the detection of mycobacteria in blood. Diagn Microbiol Infect Dis 2000 Dec; 38:223-6.Miettinen, OS. Estimation of relative risk from individually matched series. Biometrics 1970; 26:75-86.Bland, JM, Altman DG. Comparing two methods of clinical measurement: a personal history. Int J Epidemiol 1995; 24 Suppl 1:S7-14.Bouza, E, Diaz-Lopez MD, Moreno S, Bernaldo de Quiros JC, Vicente T, Berenguer J. Mycobacterium tuberculosis bacteremia in patients with and without human immunodeficiency virus infection. Arch Intern Med 1993; 153:496-500.A.T.S. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. This official statement of the American Thoracic Society was approved by the Board of Directors, March 1997. Medical Section of the American Lung Association. Am J Respir Crit Care Med 1997; 156:S1-25.Waite, RT, Woods GL. Evaluation of BACTEC MYCO/F lytic medium for recovery of mycobacteria and fungi from blood. J Clin Microbiol 1998; 36:1176-9.Jacomo, V, Musso D, Gevaudan MJ, Drancourt M. Isolation of blood-borne Mycobacterium avium by using the nonradioactive BACTEC 9000 MB system and comparison with a solid-culture system. J Clin Microbiol 1998; 36:3703-6.Esteban J, Fernandez-Roblas R, Cabria F, Soriano F. Usefulness of the BACTEC MYCO/F lytic system for detection of mycobacteremia in a clinical microbiology laboratory. J Microbiol Methods 2000; 40:63-6.

Otros artículos de Luis Alcalá Hernández

Alcalá L, García Garrote F, Cercenado E, Peláez T, Ramos G, Bouza E. Comparison of both microdilution method using Haemophilus test medium and agar dilution method for susceptibility testing of Eikenella corrodens. Journal of Clinical Microbiology. 1998; 36:2386-8.Alcalá L, Cercenado E, García Garrote F, Bouza E. In vitro activity of the new quinolone moxifloxacin (BAY 12-8039) against resistant Gram positive clinical isolates. Diagnostic Microbiology and Infectious Disease. 1999;33:27-31.Alcalá L, Ruiz Serrano MJ, Cosín J, García Garrote F, Ortega A, Bouza E. Disseminated infection due to M. simiae in an AIDS patient: case report and review. Clinical Microbiology and Infection. 1999;5:294-296.Alcalá L, Muñoz P, Rodríguez Créixems M, Bouza E. Brucella spp. peritonitis. American Journal of Medicine. 1999;107:300.Ruiz Serrano MJ, Alcalá L, Martínez Sánchez L, Díaz MS, Marín M, González Abad MJ, Bouza E. In vitro activity of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs. Antimicrobial Agents and Chemotherapy. 2000. 44;2567-2568.Martínez Sánchez L, Ruiz Serrano MJ, Bouza E, Torres L, Díaz MS, Alcalá L, Rodríguez Créixems M. Utility of the Bactec Myco/F lytic medium for the detection of mycobacteria in blood. Diagnostic Microbiology and Infectious Disease. 2001.38;223-226.Alcalá L, Ruiz Serrano MJ, Hernangómez S, Marín M, García de Viedma D, San Juan R, Bouza E. Evaluation of the upgraded amplified Mycobacterium tuberculosis direct test (Gen-Probe) for direct detection of Mycobacterium tuberculosis in respiratory and non-respiratory specimens. Diagnostic Microbiology and Infectious Disease. 2001. 41;51-56.García de Viedma D, Díaz Infantes MS, Lasala F, Chaves F, Alcalá L, Bouza E. New real time-PCR able to detect in a single tube multiple rifampin-resistance mutations and high-level isoniazid resistance mutations in Mycobacterium tuberculosis. Journal of Clinical Microbiology. 2002. 40;988-995.Alcalá L, Ruiz Serrano MJ, Pérez Fernández Turégano C, García de Viedma D, Díaz Infantes M, Marín Arriaza M, Bouza E. In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs. Antimicrobial Agents and Chemotherapy, 2003 47; 416-417.García de Viedma D, Marín Arriaza M, Ruiz Serrano MJ, Alcalá L, Bouza E. Polyclonal and compartmentalized infection by Mycobacterium tuberculosis in patients with both respiratory and extrarespiratory involvement. Journal of Infectious Diseases, 2003 187; 695-699.

Para comunicarse con Luis Alcalá Hernández mencionar a SIIC como referencia:
luisalcala@efd.net

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Acerca del trabajo completo

RENTABILIDAD DIAGNOSTICA DE LAS INFECCIONES MICOBACTERIANAS DISEMINADAS MEDIANTE MEDULA OSEA Y SANGRE

Título original en castellano
EVALUACION DE LOS CULTIVOS DE MEDULA OSEA Y SANGRE PARA LA RECUPERACION DE MICOBACTERIAS EN EL DIAGNOSTICO DE LAS INFECCIONES MICOBACTERIANAS DISEMINADAS

Autores
Luis Alcalá Hernández¹, Enrique Pacios², María Jesús Ruiz Serrano³, Darío García de Viedma⁴, Marta Rodríguez Créixems⁵, Mercedes Marín Arriaza⁶, Juan Berenguer⁷, Emilio Bouza⁸
1 Farmaceútico, Servicio de Microbiología y Enfermedades Infecciosas VIH. Hospital General Universitario Gregorio Marañón, Adjunto
2 Médico, Hospital General Universitario Gregorio Marañón
3 Farmaceútica, Hospital General Universitario Gregorio Marañón, Adjunto
4 Biólogo, Hospital General Universitario Gregorio Marañón, Adjunto
5 Médico, Hospital General Universitario Gregorio Marañón, Adjunto
6 Farmaceútica, Hospital General Universitario Gregorio Marañón, Adjunto
7 Médico, Hospital General Universitario Gregorio Marañón, Adjunto
8 Médico, Hospital General Universitario Gregorio Marañón, Jefe de Servicio

Acceso a la fuente original
Clinical Microbiology and Infection
http://www.blackwellpublishing.com/journal.asp?ref=1198-743X&site=1

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