Paula Boaventura *

Autora invitada por SIIC

Este trabalho permitiu mostrar que os carcinomas basocelulares de indivíduos irradiados são de um tipo mais agressivo e apresentam mais frequentemente alterações do DNA mitocondrial.

SUBTIPOS HISTOLÓGICOS DOS BASALIOMAS INDUZIDOS (DE LOS BASALIOMAS INDUCIDOS) POR RADIAÇÃO

Foram observadas mais de 1300 pessoas submetidas na infância (entre 1950 e 1960) à irradiação do couro cabeludo para o tratamento de uma infeção fúngica por Tinea capitis, tendo 122 desenvolvido carcinomas basocelulares. Estes carcinomas basocelulares eram mais frequentemente do tipo infiltrativo e apresentavam mais alterações do DNA mitocondrial quando comparados com os de um grupo controlo.

*Paula Boaventura
describe para SIIC los aspectos relevantes de su trabajo
MITOCHONDRIAL D310 D-LOOP INSTABILITY AND HISTOLOGICAL SUBTYPES IN RADIATION-INDUCED CUTANEOUS BASAL CELL CARCINOMAS
Institución principal de la investigación
*University of Porto, Porto, Portugal
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Referencias bibliográficas
Bartos V, Pokorny D, Zacharova O, Haluska P, Doboszova J, Kullova M, et al.: Recurrent basal cell carcinoma: a clinicopathological study and evaluation of histomorphological findings in primary and recurrent lesions. Acta Dermatovenerol Alp Panonica Adriat 20:67-75, 2011.
Boaventura P, Bastos J, Pereira D, Soares P, Teixeira-Gomes JM. Alopecia in women submitted to childhood X-ray epilation for tinea capitis treatment. The British journal of dermatology 163(3):643-644, 2012.
Boaventura P, Soares P, Pereira D, Teixeira-Gomes J, Sobrinho-Simoes M. Head and neck lesions in a cohort irradiated in childhood for tinea capitis treatment. Lancet Infect Dis 11(3):163-164, 2011.
Boaventura P, Oliveira R, Pereira D, Soares P, Teixeira-Gomes J. Head and neck basal cell carcinoma prevalence in individuals submitted to childhood X-ray epilation for tinea capitis treatment. Eur J Dermatol 22(2):225-230, 2012.
Durham SE, Krishnan KJ, Betts J, Birch-Machin MA. Mitochondrial DNA damage in non-melanoma skin cancer. Br J Cancer 88(1):90-95, 2003.
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Otros artículos de Paula Boaventura

Boaventura P, Bastos J, Pereira D, Soares P, Teixeira-Gomes J. Alopecia in women submitted to childhood X-ray epilation for tinea capitis treatment. Br J Dermatol 163(3):643-4.
Boaventura P, Soares P, Pereira D, Teixeira-Gomes J. Sobrinho-Simões M. Head and neck lesions in a cohort irradiated in childhood for tinea capitis treatment. Lancet Infect Dis 11(3):163-4, 2011.
Boaventura P, Oliveira R, Pereira D, Soares P, Teixeira-Gomes J. Head and neck basal cell carcinoma prevalence in individuals submitted to childhood X-ray epilation for tinea capitis treatment. Eur J Dermatol 22(2):225-30, 2012.
Boaventura P, Pereira D, Soares P, Teixeira-Gomes J. A Campanha da Tinha em Portugal - epidemia do passado e possíveis sequelas futuras. Publicação Oncológica Portuguesa,5:22-34, 2012.
Boaventura P, Pereira D, Teixeira-Gomes J, Soares P. Radiation treatment and alopecia - past and present concerns. In the book Alopecia: causes, diagnosis and treatment, published by Nova Science Publishers, Inc., Chapter I, pp. 1-22, 2012.
Boaventura P, Pereira D, Celestino R, Mendes A, Nakasawa T, Teixeira-Gomes J, Sobrinho-Simões M, Soares P. Genetic alterations in thyroid tumours from patients irradiated in childhood for tinea capitis treatment. Eur J Endocrinol 169(5):673-9, 2013. doi: 10.1530/EJE-13-0543.
Almeida A, Boaventura P, Soares P. Etiopathogenic factors of thyroid cancer. In the e-book Clinical management of thyroid cancer, published by Future Science Group, pp. 42-62, 2013. Doi: 10.2217/ebo.13.37.
Boaventura P, Pereira D, Mendes A, Teixeira-Gomes J, Sobrinho-Simões M, Soares P. Thyroid and parathyroid tumours in patients submitted to X-ray scalp epilation during the tinea capitis eradication campaign in the North of Portugal (1950-1963). Virchows Arch 465(4):445-52, 2014. doi: 10.1007/s00428-014-1644-0.
Pópulo H, Boaventura P, Vinagre J, Batista R, Mendes A, Caldas R, Pardal J, Azevedo F, Honavar M, Guimarães I, Lopes JM, Sobrinho-Simões M, Soares P. TERT promoter mutations in skin cancer: effect of sun exposure and irradiation. J Invest Dermatol 134(8):2251-7, 2014. doi: 10.1038/jid.2014.163.

Para comunicarse con Paula Boaventura mencionar a SIIC como referencia:
psoares@ipatimup.pt

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SUBTIPOS HISTOLÓGICOS DOS BASALIOMAS INDUZIDOS (DE LOS BASALIOMAS INDUCIDOS) POR RADIAÇÃO

Título original en castellano
INSTABILIDADE MITOCONDRIAL DO D-LOOP E SUBTIPOS HISTOLOGICOS NOS CARCINOMAS BASOCELULARES CUTÂNEOS INDUZIDOS PELA RADIAÇÃO

Autores
Dina Pereira¹, Adélia Mendes², Rui Batista³, André Ferreira Da Silva⁴, Isabel Guimarães⁵, Mrinalini Honavar⁶, José Teixeira-Gomes⁷, José Manuel Lopes⁸
1 Investigadora
2 Investigadora, Bolseira de Investigação
3 Investigador, Ipatimup, Bolseiro de Investigação
4 Investigador
5 Médica, Hospital Pedro Hispano, Médica
6 Médica, Hospital Pedro Hispano, Médica
7 Médico, Ipatimup
8 Médico, Faculdade de Medicina da Universidade Do Porto, Médico / Professor

Acceso a la fuente original
Journal of Dermatological Science
http://www.harcourt-international.com/journals/jods/

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