David Conde-Estévez *

Autor invitado por SIIC

Revisión crítica y aséptica de la evidencia en el tratamiento de extravasaciones por antraciclinas y de la situación actual

TRATAMIENTO DE LAS EXTRAVASACIONES POR ANTRACILINAS CON DEXRAZOXANO

En la actualidad, el único fármaco autorizado para tratar las extravasaciones por antraciclinas es el dexrazoxano. A pesar de ello, otras aproximaciones terapéuticas están disponibles y han demostrado su eficacia como es el caso del dimetilsulfóxido (DMSO) al 90-99%. Se plantea una revisión crítica y aséptica de la evidencia publicada de ambos y la situación actual. La conclusión a la que llegamos es que con la evidencia actual no podemos recomendar inequívocamente una alternativa o otra. Debería realizarse un estudio comparativo entre ambas aproximaciones terapéuticas a fin de poder determinar el mejor manejo en el caso de extravasaciones por antraciclinas.

*David Conde-Estévez
describe para SIIC los aspectos relevantes de su trabajo
TREATMENT OF ANTHRACYCLINE EXTRAVASATIONS USING DEXRAZOXANE
Institución principal de la investigación
*Department Of Pharmacy, Hospital Universitari del Mar. Parc de Salut Mar, Universitat Autònoma de Barcelona, Barcelona, España
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Otros artículos de David Conde-Estévez

Conde-Estevez D, Mateu-de Antonio J. Comment on: management of chemotherapy extravasation: ESMO-EONS clinical practice guidelines. Ann Oncol. 2013;24(4):1128–9; author reply 9–30. doi:10.1093/annonc/mdt021 mdt021. Conde-Estevez D, Saumell S, Salar A, Mateu-de Antonio J. Successful dexrazoxane treatment of a potentially severe extravasation of concentrated doxorubicin. Anticancer Drugs. 2010;21(8):790–4. doi:10.1097/CAD.0b013e32833d903200001813-201009000-00009. Conde-Estévez D, Salas E, Albanell J. Survey of oral chemotherapy safety and adherence practices of hospitals in Spain. Int J Clin Pharm. 2013 Dec;35(6):1236-44. doi: 10.1007/s11096-013-9858-9. Epub 2013 Oct 16. Conde-Estévez D, Mateu-de Antonio J. [Update in the management of extravasations of cytocytostatic agent]. Farm Hosp. 2012 Jan-Feb;36(1):34-42. doi:10.1016/j.farma.2011.01.002. Epub 2011 Jul 27. Review. Spanish.

Para comunicarse con David Conde-Estévez mencionar a SIIC como referencia:
dconde@hospitaldelmar.cat

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Acerca del trabajo completo

TRATAMIENTO DE LAS EXTRAVASACIONES POR ANTRACILINAS CON DEXRAZOXANO

Título original en castellano
TRATAMIENTO CON DESRAZOXANO DE LAS EXTRAVASACIONES POR ANTRACILINAS

Autor
David Conde-Estévez¹
1 Farmacéutico Clínico, Department Of Pharmacy, Hospital Universitari del Mar. Parc de Salut Mar, Universitat Autònoma de Barcelona, Barcelona, España, Farmacéutico Adjunto

Acceso a la fuente original
Clinical & Translational Oncology
http://www.springer.com/medicine/oncology/journal/12094

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