Nilo Ikuta *

Autor invitado por SIIC

O trabalho descreve os primeiros casos de vírus H1N1pdm09 resistentes a oseltamivir no Brasil.

H1N1 RESISTENTES A OSELTAMIVIR NO SUL DO BRASIL

Foram identificados dois mutantes resistentes ao inibidor NA, (H275Y e S247N). Este estudo revelou uma baixa prevalência (0,8%), sem propagação de vírus resistentes em todo Estado do Rio Grande do Sul.

*Nilo Ikuta
describe para SIIC los aspectos relevantes de su trabajo
OSELTAMIVIR-RESISTANT INFLUENZA A(H1N1)PDM09 VIRUS IN SOUTHERN BRAZIL
Institución principal de la investigación
*Universidade Luterana Do Brasil, Canoas, Brasil
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Referencias bibliográficas
Hurt AC, Deng YM, Ernest J, Caldwell N, Leang L, Iannello P, et al. Oseltamivir-resistant influenza viruses circulating during the first year of the influenza A(H1N1) 2009 pandemic in the Asia-Pacific region, March 2009 to March 2010. Euro Surveill. 2011;16:24-31.
World Health Organization. Update on oseltamivir resistance in influenza A (H1N1) 2009 viruses. [cited 2011 Aug 24]. http://www.who.int/influenza/surveillance_
monitoring/updates/2011_08_26_weekly_web_update_oseltamivir_resistance.pdf
Kiso M, Shinya K, Shimojima M, Takano R, Takahashi K, Katsura H, et al. Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses. PLoS Pathog. 2010;6:1-7.
Renaud C, Kuypers J, Englund JA. Emerging oseltamivir resistance in seasonal and pandemic influenza A/H1N1. J Clin Virol. 2011;52:70-8.
Sheu T, Deyde V, Okomo-Adhiambo M, Garten R, Xu X, et al. Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008. Antimicrob Agents Chemother. 2008; 52:3284-92.
Gregianini TS, Dambrós BP, Tumioto GL, Seadi C, Baccin T, Ardenghi P, et al. Laboratory Diagnosis of Influenza in Rio Grande do Sul, from 2009 to 2011 [in Portuguese]. Bol Epidemiológico. 2011;13:13-16.
Deyde VM, Sheu TG, Trujillo AA, Okomo-Adhiambo M, Garten R, Klimov AI, et al. Detection of molecular markers of drug resistance in 2009 pandemic influenza A (H1N1) viruses by pyrosequencing. Antimicrob Agents Chemother. 2010;54:1102–10.
Hurt A, Holien J, Parker M, Kelso A, Barr I. Zanamivir-resistant influenza viruses with a novel neuraminidase mutation. Journal of Virology. 2009; 83:10366-10373.
Le QM, Wertheim HF, Tran ND, van Doorn HR, Nguyen TH, Horby P. A commu-nity cluster of oseltamivir-resistant cases of 2009 H1N1 influenza. New Engl J Med. 2010;362:86–7.
Ison MG, Mishin VP, Braciale TJ, Hayden FG, Gubareva LV. Comparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infection. J Infect Dis. 2006;193:765–772.
World Health Organization. Influenza A virus resistance to oseltamivir and other antiviral medicines. [cited 2009]. http://www.who.int/csr/disease/
influenza/2008- 9nhemisummaryreport/en/index.html.
Meijer A, Lackenby A, Hungnes O, Lina B, Werf van der S, Schweiger B, et al. Oseltamivir-resistant influenza virus A(H1N1), Europe, 2007-08 season. Emerg Infect Dis 2009;15:552-560.
Dharan NJ, Gubareva LV, Meyer JJ, Okomo-Adhiambo M, McClinton RC, Mar-shall SA, et al. Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States. JAMA 2009;301:1034–41.
Kawai N, Ikematsu H, Hirotsu N, Maeda T, Kawashima T, Tanaka O, et al. Clinical effectiveness of oseltamivir and zanamivir for treatment of influenza A virus subtype H1N1 with the H274Y mutation: a Japanese, multicenter study of the 2007-2008 and 2008-2009 influenza seasons. Clin Infect Dis. 2009;49:1828-35.
Ledesma J, Vicente D, Pozo F, Cilla G, Castro SP, Fernández JS, et al. The Spanish Influenza Surveillance System (SISS). Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain. J Clin Virol. 2011;51:205-208.