Pilar Codoñer-Franch *

Autora invitada por SIIC

Es la primera demostración referida del aumento de las poliaminas en niños afectos de obesidad.

INCREMENTO DE LAS POLIAMINAS EN NIÑOS OBESOS

En los niños obesos se encuentra un aumento de las poliaminas en sangre. La espermina (poliamina que presenta mayor poder discriminativo con respecto a la obesidad) se correlaciona con marcadores de inflamación, estrés oxidativo y nitrosativo y de angiogénesis. Esta relación puede apoyar la aparición de comorbilidades en niños obesos. Su relación con el incremento de riesgo cancerígeno en la obesidad merece investigaciones posteriores.

*Pilar Codoñer-Franch
describe para SIIC los aspectos relevantes de su trabajo
POLYAMINES ARE INCREASED IN OBESE CHILDREN AND ARE RELATED TO MARKERS OF OXIDATIVE/NITROSATIVE STRESS AND ANGIOGENESIS
Institución principal de la investigación
*University Hospital Doctor Peset, Valencia, España
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Referencias bibliográficas
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5. Codoñer-Franch P, Tavárez-Alonso S, Murria-Estal R, Megías-Vericat J, Tortajada-Girbés M, Alonso-Iglesias E. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atherosclerosis 215:475-480, 2011.
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Otros artículos de Pilar Codoñer-Franch

Codoñer-Franch P, Boix-García L, Simó-Jordá R, Del Castillo-Villaescusa C, Maset-Maldonado J, Valls-Bellés V. Is obesity associated with oxidative stress in children? International Journal of Pediatric Obesity 5:56-63, 2010.
Codoñer-Franch P, Boix-García L, Pons-Morales S, Valls-Bellés V. Oxidant/antioxidant status in obese children compared to pediatric patients with type 1 diabetes mellitus. Pediatric Diabetes 11:251-257, 2010.
Codoñer-Franch P, López-Jaén AB, De la Mano-Hernández A, Sentandreu E, Simó-Jordá R, Valls-Bellés V. Oxidative markers in children with severe obesity following low-calorie diets supplemented with mandarin juice. Acta Paediatrica 99:1841-1846, 2010.
Codoñer-Franch P, Ballester-Asensio E, Martínez-Pons L, Vallecillo-Hernández J, Navarro-Ruíz A, Del Valle-Pérez R. Cystatin C, cardiometabolic risk, and body composition in severe obese children. Pediatric Nephrology 26:301-307, 2011.
Codoñer-Franch P, Tavárez-Alonso S, Murria-Estal R, Megías-Vericat J, Tortajada-Girbés M, Alonso-Iglesias E. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atherosclerosis 215:475-480, 2011.
Codoñer-Franch P, Valls-Bellés V, Arilla-Codoñer A, Alonso-Iglesias E. Oxidant mechanisms in childhood obesity: the link between inflammation and oxidative stress. Translational Research 158:369-384, 2011.
Codoñer-Franch P, Tavárez-Alonso S, Simó-Jordá R, Laporta-Martín P, Carratalá-Calvo A, Alonso-Iglesias E. Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children. The Journal of Pediatrics 161:848-854, 2012.
Codoñer-Franch P, Mora-Herranz A, Simó-Jordá R, Pérez-Rambla C, Boix-García L, Faus-Pérez A. Retinol-binding protein 4 levels are associated with parameters of liver and renal function and oxidant/antioxidant status in obese children. The Journal of Pediatrics 163:593-595, 2013.
Codoñer-Franch P, Tavárez-Alonso S, Porcar-Almela M, Navarro-Solera M, Arilla-Codoñer A, Alonso-Iglesias E. Plasma resitin levels are associated to homocysteine, endothelial acivation and nitrosative stress in obese youths. Clinical Biochemistry 47:44-48, 2014.
Porcar-Almela M, Codoñer-Franch P, Tuzón M, Navarro-Solera M, Carrasco-Luna J, Ferrando J. Left ventricular diastolic function and cardiometabolic factors in obese normotensive children. Nutrition, Metabolism and Cardiovascular Diseases 25:108-115, 2015.

Para comunicarse con Pilar Codoñer-Franch mencionar a SIIC como referencia:
pilar.codoner@uv.es

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Acerca del trabajo completo

INCREMENTO DE LAS POLIAMINAS EN NIÑOS OBESOS

Título original en castellano
LAS POLIAMINAS ESTAN AUMENTADAS EN NIÑOS OBESOS Y SE RELACIONAN CON LOS MARCADORES DE ESTRES OXIDATIVO/NITROSATIVO Y ANGIOGENESIS

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Acceso a la fuente original
Journal of Clinical Endocrinology and Metabolism
http://jcem.endojournals.org

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