Gracia Merino *

Autor invitado por SIIC

La utilización de diversas metodologías in vitro e in vivo es fundamental para el estudio de interacciones farmacológicas

LA COADMINISTRACIÓN DE IVERMECTINA DISMINUYE LOS NIVELES EN LECHE DEL ANTIBIÓTICO DANOFLOXACINO EN OVEJAS

En este trabajo identificamos el mecanismo mediante el que una fluoroquinolona de amplio uso veterinario como el danofloxacino es secretada de forma activa a la leche y cómo ese mecanismo puede ser inhibido mediante la coadministración de un antiparasitario como la ivermectina.

*Gracia Merino
describe para SIIC los aspectos relevantes de su trabajo
INVOLVEMENT OF BREAST CANCER RESISTANCE PROTEIN (BCRP/ABCG2) IN THE SECRETION OF DANOFLOXACIN INTO MILK: INTERACTION WITH IVERMECTIN
Institución principal de la investigación
*Universidad de León, León, España
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Referencias bibliográficas
Allen, J.D., van Loevezijn, A., Lakhai, J.M., van der Valk, M., van Tellingen, O., Reid, G., Schellens, J.H., Koomen, G.J. & Schinkel, A.H. (2002) Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Molecular Cancer Therapeutics, 1, 417–425. Barrera, B., González-Lobato, L., Otero, J.A., Real, R., Prieto, J.G., Álvarez, A.I. & Merino, G. (2013) Effects of triclabendazole on secretion of danofloxacin and moxidectin into the milk of sheep: role of triclabendazole metabolites as inhibitors of the ruminant ABCG2 transporter. The Veterinary Journal,198, 429-436. Jonker, J.W., Merino, G., Musters, S., van Herwaarden, A.E., Bolscher, E., Wagenaar, E., Mesman, E., Dale, T.C. & Schinkel, A.H. (2005) The Breast Cancer Resistance Protein (BCRP ⁄ ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nature Medicine, 11, 127–129. Pavek, P., Merino, G., Wagenaar, E., Bolscher, E., Novotna, M., Jonker, J.W. & Schinkel, A.H. (2005) Human breast cancer resistance protein (BCRP ⁄ ABCG2): interactions with steroid drugs, hormones, the dietary carcinogen PhIP, and transport of cimetidine. Journal of Pharmacology and Experimental Therapeutics, 312, 144–152. Perez, M., Otero, J.A., Barrera, B., Prieto, J.G., Merino, G. & Alvarez, A.I. (2013) Inhibition of ABCG2/BCRP transporter by soy isoflavones genistein and daidzein: effect on plasma and milk levels of danofloxacin in sheep. The Veterinary Journal, 196, 203-208.

Otros artículos de Gracia Merino

1. Otero JA; Barrera B; De la Fuente A; Prieto JG; Marqués M; Alvarez AI; Merino G. 2015. The gain-of-function Y581S polymorphism of the ABCG2 transporter increases secretion into milk of danofloxacin at the therapeutic dose for mastitis treatment. Journal of Dairy Science. 98 - 1, pp. 312 - 317.
2. Moreno-Sanz G; Barrera B; Armirotti A; Bertozzi SM; Scarpelli R; Bandiera T; Prieto JG; Duranti A; Tarzia G; Merino G; Piomelli D. 2014. Structural determinants of peripheral Oarylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain. Pharmacological Research. 87, pp. 87 - 93.
3. Otero JA; Real R; De la Fuente A; Prieto JG; Marqués M; Alvarez AI; Merino G. 2013. The bovine ATP-binding cassette transporter ABCG2 Y581S single nucleotide polymorphism increases milk secretion of the fluoroquinolone danofloxacin. Drug Metabolism and Disposition. 41 - 3, pp. 546 - 549.
4. Barrera B; Otero JA; Egido E; Prieto JG; Seelig A; Álvarez AI; Merino G. 2012. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrobial Agents and Chemotherapy. 56 - 7, pp. 3535 - 3543.
5. Merino G; Perez M; Real R; Egido E; Prieto JG; Alvarez AI. In Vivo Inhibition of BCRP/ABCG2 Mediated Transport of Nitrofurantoin by the Isoflavones Genistein and Daidzein: A Comparative Study in Bcrp1 (-/-) Mice. 2010. Pharmaceutical Research. 27 - 10, pp. 2098 - 2105.
6. Merino G; Real R; Baro MF; Gonzalez-Lobato L; Prieto JG; Alvarez AI; Marques MM. 2009. Natural allelic variants of bovine ABCG2 transporter: Increased activity of the S581 variant and development of tools for the discovery of new ABCG2 inhibitors. Drug Metabolism and Disposition. 37 - 1, pp. 5 – 9.
7. Merino G; Pulido MM; Álvarez AI; Molina AJ; Prieto JG; Álvarez AI. Breast Cancer Resistance Protein (bcrp/abcg2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics and milk secretion (ABCG2/BCRP). 2006. Drug Metabolism and Disposition. 34 - 4, pp. 690 - 695.
8. Merino G; van Herwaarden AE; Wagenaar E; Jonker JW; Schinkel AH. 2005. Sex dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver. Molecular Pharmacology. 67 - 5, pp. 1765 - 1771.
9. Merino G; Jonker JW; Wagenaar E; van Herwaarden AE; Schinkel AH. 2005. The Breast Cancer Resistance Protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion and milk secretion of the antibiotic nitrofurantoin. Molecular Pharmacology. 67 - 5, pp. 1758 - 1764.
10. Jonker JW; Merino G; Musters S; van Herwaarden AE; Bolscher E; Wagenaar E; Mesman E; Dale TC; Schinkel AH. 2005. The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nature Medicine. 11 - 2, pp. 127 - 129.

Para comunicarse con Gracia Merino mencionar a SIIC como referencia:
gmerp@unileon.es

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Acerca del trabajo completo

LA COADMINISTRACIÓN DE IVERMECTINA DISMINUYE LOS NIVELES EN LECHE DEL ANTIBIÓTICO DANOFLOXACINO EN OVEJAS

Título original en castellano
IMPLICACION DE BREAST CANCER RESISTANCE PROTEIN (ABCG2/BCRP) EN LA SECRECION DE DANOFLOXACINO A LECHE: INTERACCION CON IVERMECTINA

Autores
Gracia Merino¹, Ana Isabel Alvarez De Felipe², Rebeca Real³, Miriam Pérez⁴, Lucía González-Lobato⁵, Borja Barrera⁶, Julio Gabriel Prieto Fernández⁷
1 Profesor de Universidad, Universidad de León, León, España, Profesor Titular de Universidad
2, Universidad de León
3, Universidad de León
4, Universidad de León
5, Universidad de León
6, Universidad de León
7, Universidad de León

Acceso a la fuente original
Journal of Veterinary Pharmacology and Therapeutics
http://www.blackwellpublishing.com/journal.asp?ref=0140-7783&site=1

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