María Cecilia Johnson Pena *

Autora invitada por SIIC

Este estudio contribuye a entender la influencia del fluido peritoneal en el desarrollo de la endometriosis

CONTRIBUCION DEL LIQUIDO PERITONEAL EN LA PATOGENIA DE LA ENDOMETRIOSIS

El líquido peritoneal de mujeres con endometriosis indujo la expresión de P450Arom y SF1 en células de endometrio control sugiriendo que moléculas constituyentes podrían estar participando en la etiopatogénesis de la endometriosis favoreciendo el microambiente estrogénico del endometrio eutópico, y la viabilidad y crecimiento de implantes endometriales en locaciones ectópicas.

*María Cecilia Johnson Pena
describe para SIIC los aspectos relevantes de su trabajo
P450AROM INDUCTION IN ISOLATED CONTROL ENDOMETRIAL CELLS BY PERITONEAL FLUID FROM WOMEN WITH ENDOMETRIOSIS
Institución principal de la investigación
*Universidad de Chile, Santiago, Chile
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Referencias bibliográficas
1. Giudice L. 2010. Endometriosis. N Engl J Med 362:2389-2398.

2. Kao LC, Germeyer A, Tulac S, Lobos S, Yang JP, Taylor RN, Osteen K, Lessey BA, Giudice LC. 2003. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology 144:2870-2881.

3. Matsuzaki S, Canis M, Vaurs-Barriere C, Pouly JL, Boespflug-Tanguy O, Penault-Llorca F, Dechelotte B, Okamura K, Mage G. 2005. DNA microarray analysis of gene expression profiles in deep endometriosis using laser capture microdissection. Mol Hum Repord 10:719-728.

4. Wu Y, Kajdacsy-Balla A, Strawn E, Basir Z, Halverson G, Jailwala P, Wang Y, Wang X, Ghosh S, Guo SW. 2006. Transcriptional characterization of differences between eutopic and ectopic endometrium. Endocrinol 147:232-246.

5. Zhang H, Yidong N, Feng J, Guo H, Ye X, Cui H. 2006. Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls. Fertil Steril 86, 274-282.

6. Noble LS, Simpson ER, Johns A, Bulun SE. 1996. Aromatase expression in endometriosis. J Clin Endocrinol Metab 81:174-179.

7. Kitawaki J, Kusuki I, Koshiba H, Tsukamoto K, Honjo H. 1999. Expression of Aromatase Cytochrome P450 in Eutopic Endometrium and Its Application as a Diagnostic Test for Endometriosis. Gynecol Obstet Invest 48:21-8

8. Dheenadayalu K, Mak I, Gordts S, Campo R, Higham J, Puttemans P, et al. 2002. Aromatase P450 messenger RNA expression in eutopic endometrium is not a specific marker for pelvic endometriosis. Fertil Steril;78:825-829.

9. Johnson MC, Pinto C, Alves A, Palomino A, Fuentes A, Boric MA, Vega M. 2004. P450Arom and estrogenic microenvironment of eutopic endometria in endometriosis Rev Med Chile 132:1475-1482.

10. Wölfler MM, Nagele F, Kolbus A, Seidl S, Schneider B, Huber JC, Tschugguel W. 2005. A predictive model for endometriosis. Hum Reprod;20:1702-1708.

11. Bulun SE. 2009. Endometriosis. N Eng J Med 360:268-279.

12. Bulun SE, Lin Z, IMIR G, Amin S, Demura M, Yilmaz B, Martin R, Utsunomiya H, Thung S, Gurates B, Tamura M, Langoi D, Deb S. 2005. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from the bencg to treatment. Pharmacol Rev 57:359-383.

13. Castro J, Torres M, Sovino H, Fuentes A, Boric MA, Johnson MC. 2010. P450Arom induction in isolated control endometrial cells by peritoneal fluid from women with endometriosis. Fertil Steril 44:2521-2527.

14. Meresman GF, Vighi s, Buquet RA, Contreras-Ortiz O, tesone M, Rumi LS. 2000. Apoptosis and expresión of Bcl-2 and Bax in eutopic endometrium from women with endometriosis. Fertile Steril 74:760-766.

15. Johnson MC, Torres M, Alves A, Bacallao K, Fuentes A, Vega M, Boric MA. 2005. Augmented cell survival in eutopic endometrium from women with endometriosis: expression of c-myc, TGF-beta1 and bax genes. Reprod Biol Endocrinol 3:45-52, doi:10.1186/1477-7827-3-45.

16. Shewin JRA, Sharkey AM, Mihalyi A, Simsa P, Catalano RD, D’Hooghe TM. 2008. Global gene analysis of late secretory phase, eutopic endometrium does not provide the basis for a minimally invasive test of endometriosis. Human Reprod 23:1063-1068.

17. Kyama CM, Overbergh L, Debrock S, valckx D, Vander Perre S, Meuleman C, Mihalyi A, Mwenda JM, Matheiu C, D’Hooghe TM. 2006. Increased peritoneal and endometrial gene expresión of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis. Fertil Steril 85: 1667-1675.

18. Pino M, Galleguillos C, Torres M, Sovino H, Fuentes A, Boric MA, Johnson MC. 2009. Association between MMP1 and MMP9 actvities and ICAM1 cleavage induced by tumor necrosis factor in stromal cell cultures from eutopic endometria of women with endometriosis. Reprod 138:837-847.

Otros artículos de María Cecilia Johnson Pena

1. Castro J, Torres M, Sovino H, Fuentes A, Boric MA, Johnson MC. P450Arom induction in isolated control endometrial cells by peritoneal fluid from women with endometriosis. Fertil Steril 44:2521-2527, 2010.

2. Pino M, Galleguillos C, Torres M, Sovino H, Fuentes A, Boric MA, Johnson MC. Association between MMP1 and MMP9 actvities and ICAM1 cleavage induced by tumor necrosis factor in stromal cell cultures from eutopic endometria of women with endometriosis. Reprod 138:837-847, 2009.

3. Ponce C, Torres M, Galleguillos C, Sovino H, Boric MA, Fuentes A, Johnson MC. Nuclear factor kB pathway and interleukin-6 are affected in eutopic endometrium of women with endometriosis. Reproduction 137:727-737, 2009.

4. Maliqueo M, Bacallao K, Quezada S, Clementi M, Gabler F, Johnson MC, Vega M. Sex hormone binding globulin (SHBG) expression on endometria of women with polycystic ovary syndrome. Fertil Steril 87:321-328, 2007.

5. Quezada S, Avellaira C, Johnson MC, Gabler F, Fuentes A, Vega M. Evaluation of steroid receptors, co-regulators and molecules associated to uterine receptivity in mid secretory endometria from untreated women with Polycystic Ovary Syndrome. Fertil Steril 85:1017-1026, 2006.

6. Johnson MC, Torres M, Alves A, Bacallao K, Fuentes A, Vega M, Boric MA. Augmented cell survival in eutopic endometrium from women with endometriosis: expression of c-myc, TGF-beta1 and bax genes. Reprod Biol Endocrinol 3:45-52, doi:10.1186/1477-7827-3-45, 2005.

7. Johnson MC, Pinto C, Alves A, Palomino A, Fuentes A, Boric MA, Vega M. P450Arom and estrogenic microenvironment of eutopic endometria in endometriosis Rev Med Chile 132:1475-1482, 2004.

8. Maliqueo M, Quezada S, Clementi M, Bacallao K, Anido M, Johnson C, Vega M. Potential action of androstenedione on the proliferation and apoptosis of stromal endometrial cells Reproductive Biology and Endocrinology 2: 81-82, 2004.

9. Johnson MC, Maliqueo M, Boric MA, Villavicencio A, Gabler F, Vantman D, Vega M. Differential actions of nitric oxide on human endometrial cell survival during culture”. Fertil Steril 81: 176-184, 2004.

10. Castro A, Johnson MC, Anido M, Cortinez A, Gabler F, Vega M. Role of Nitric Oxide and Bcl-2 Family Gene in the Regulation of Endometrial Apoptosis” Fertil Steril, 78:587-95, 2002

Para comunicarse con María Cecilia Johnson Pena mencionar a SIIC como referencia:
cjohnson@med.uchile.cl

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Acerca del trabajo completo

CONTRIBUCION DEL LIQUIDO PERITONEAL EN LA PATOGENIA DE LA ENDOMETRIOSIS

Título original en castellano
FLUIDO PERITONEAL DE MUJERES CON ENDOMETRIOSIS FAVORECE EXPRESION DE AROMATASA EN CELULAS ENDOMETRIALES

Autores
María Cecilia Johnson Pena¹, Jazmin Castro², Marisa Torres³, Hugo Sovino⁴, Ariel Fuentes⁵, María Angélica Boric⁶
1 Bioquímica, Universidad de Chile, Santiago, Chile, Profesora Asociada
2 Bioquímica, Instituto de Investigaciones Materno-infantil, Facultad de Medicina, Universidad de Chile, Ayudante de Investigación
3 Tecnóloga Médica, Instituto de Investigaciones Materno-infantil, Facultad de Medicina, Universidad de Chile, Ayudante de Investigación
4 Médico, Instituto de Investigaciones Materno-infantil, Facultad de Medicina, Universidad de Chile, Médico
5 Médico, Instituto de Investigaciones Materno-infantil, Facultad de Medicina, Universidad de Chile, Profesor Asistente
6 Bioquímica, Instituto de Investigaciones Materno-infantil, Facultad de Medicina, Universidad de Chile, Profesora

Acceso a la fuente original
Fertility and Sterility
http://www.fertstert.org/

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