Benjamín Fernández-Gutiérrez *

Autor invitado por SIIC

El trabajo es la primera descripción proteómica de las células madre mesenqumales en la artrosis. Es el fruto de una colaboración entre un hospital y un centro de investigación nacional y se encuadra en el contexto de la medicina traslacional

PROTEOMA DIFERENCIAL DE CELULAS MADRE MESENQUIMALES DE PACIENTES CON ARTROSIS

En este artículo describimos las proteínas diferenciales de las células madre mesenquimales de médula ósea de pacientes con artrosis. Estas proteínas están mayormente relacionadas con el citoesqueleto y la obtención de energía en probable conexión con la respuesta quimiotáctica incrementada de estas células en el contexto de la artrosis.

*Benjamín Fernández-Gutiérrez
describe para SIIC los aspectos relevantes de su trabajo
DIFFERENTIAL PROTEOME OF BONE MARROW MESENCHYMAL STEM CELLS FROM OSTEOARTHRITIS PATIENTS
Institución principal de la investigación
*Hospital Clínico San Carlos, Madrid, España
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Otros artículos escogidos

Referencias bibliográficas
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Otros artículos de Benjamín Fernández-Gutiérrez

De Miguel S, Jover JA, Vadillo C, Judez E, Loza E, Fernández-Gutiérrez B. B cell activation in rheumatoid arthritis patients under infliximab treatment. Clin Exp Rheumatol 21:726-732, 2003.
Martínez A, Salido M, Bonilla G, Pascual-Salcedo D, Fernández-Arquero M, Balsa A, Gómez de la Concha E, Fernández-Gutiérrez B. MHC association with response to monoclonal anti-TNF alpha therapy in rheumatoid arthritis. Artritis Rheum 50:1077-1082, 2004.
Alvarez-Lafuente R, Fernández-Gutiérrez B, Jover JA, Judez E, Loza E, Clemente D, García-Asenjo JA, Lamas JR. Human parvovirus B19, varicella zoster virus, and human herpes virus 6 in temporal artery biopsy specimens of patients with giant cell arteritis: analysis with quantitative real time polymerase chain reaction. Ann Rheum Dis 64(5):780-2, 2005.
Alvarez-Lafuente R, Fernández-Gutiérrez B, De Miguel S, Jover JA, Rollin R, Loza E, Clemente D, Lamas JR. Potential relationship between herpes viruses and rheumatoid arthritis: analysis with quantitative real time polymerase chain reaction. Ann Rheum Dis 64(9):1357-9, 2005.
Rollín R, Alvarez-Lafuente R, Marco F, Jover JA, Hernández-García C, Rodríguez-Navas C, López-Durán L, Fernández-Gutiérrez B. Human parvovirus B19, varicela zoster virus, and human herpes virus 6 in mesenchymal stem cells of patients with osteoarthritis: Analysis with quantitative real time polymerase chain reaction. Osteoarthritis Cartilage 15(4):475-8, 2007.
Rollín R, Marco F, Jover JA, García-Asenjo JA, Rodríguez L, López-Durán L, Fernández-Gutiérrez B. Early lymphocyte activation in the synovial microenvironment in patients with osteoarthritis: comparison with rheumatoid arthritis patients and healthy controls. Rheumatol Int 28(8):757-64, 2008.
Rollín R, Marco F, Camafeita E, Calvo E, López-Durán L, Jover JA, López JA, Fernández-Gutiérrez B. Differential proteome of bone marrow mesenchymal stem cells from osteoarthritis patients. Osteoarthritis Cartilage 16(8):929-35, 2008.

Para comunicarse con Benjamín Fernández-Gutiérrez mencionar a SIIC como referencia:
bfernandez.hcsc@salud.madrid.o

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Acerca del trabajo completo

PROTEOMA DIFERENCIAL DE CELULAS MADRE MESENQUIMALES DE PACIENTES CON ARTROSIS

Título original en castellano
PROTEOMA DIFERENCIAL DE CELULAS MADRE MESENQUIMALES DE PACIENTES CON ARTROSIS

Autores
Benjamín Fernández-Gutiérrez¹, Raquel Rollin², Fernando Marco³, Emilio Camafeita⁴, Enrique Calvo⁵, Luis Lopez-Duran⁶, Juan Angel Jover⁷, Juan Antonio Lopez⁸
1 Médico, Hospital Clínico San Carlos, Madrid, España, Facultativo Especialista Reumatología
2 Investigadora, Hospital Clinico San Carlos, Investigadora
3 Medico, Hospital Clinico San Carlos, Facultativo Especialista Traumtologia
4 Quimico, Cnic, Tecnico Senior
5 Biologo, Cnic, Tecnico Senior
6 Medico, Hospital Clinico San Carlos, Jefe de Servicio Traumatologia
7 Medico, Hospital Clinico San Carlos, Jefe de Servicio Reumatologia
8 Quimico, Cnic, Jefe de Servicio Proteomica

Acceso a la fuente original
Osteoarthritis and Cartilage
http://www.elsevier.com/wps/find/journaldescription.cws_home/623055/description#description

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