JC Chacques *

Autor invitado por SIIC

Este trabajo enumera los tipos celulares que pueden utilizarse para regenerar el miocardio y sus mecanismos de acción

TRASPLANTE DE CELULAS MADRE PARA REGENERAR Y ASISTIR EL CORAZON

La medicina regenerativa comenzó a desarrollarse gracias a las recientes innovaciones en el dominio de la biología celular (aplicacion de células madre multipotentes) y a otras disciplinas como la ingenieria de tejidos, bioquimica, biofisica, genética y biología molecular. El trasplante de células progenitoras indiferenciadas en el miocardio patologico regenera las células cardíacas y su matriz extracelular a través de mecanismos de “angiogénesis” y “miogénesis”. El objetivo de las técnicas de regeneración es el restablecimiento de la estructura y función de tejidos lesionados, la finalidad principal es evitar el trasplante de órganos.

*JC Chacques
describe para SIIC los aspectos relevantes de su trabajo
CELLULAR CARDIOMYOPLASTY FOR MYOCARDIAL REGENERATION
Institución principal de la investigación
*Department of Cardiovascular Surgery, European Hospital Georges Pompidou, París, Francia
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Referencias bibliográficas
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Otros artículos de JC Chacques

Carpentier A, Chachques JC, Grandjean PA (eds): libro “Cardiac Bioassist”. Futura Publishing, New York (USA), 1997: 632 páginas.

Chachques JC, Duarte F, Cattadori B, Shafy A, Lila N, Chatellier G, Fabiani JN, Carpentier A. Angiogenic growth factors and/or cellular therapy for myocardial regeneration: a comparative study. J Thorac Cardiovasc Surg 2004; 128:245-253.

Chachques JC, Herreros J, Trainini JC (eds): libro “Regeneracion Cardíaca”. Editorial Magister Eos, Buenos Aires (Argentina), 2005 :205 págs.

Chachques JC, Acar C, Herreros J, Trainini JC, Prosper F, D\'Attellis N, Fabiani JN, Carpentier A. Cellular cardiomyoplasty: clinical application. Ann Thorac Surg 2004; 77:1121-1130.

Chachques JC, Herreros J, Trainini J, Juffe A, Rendal E, Prosper F, Genovese J. Autologous human serum for cell culture avoids the implantation of cardioverter-defibrillators in cellular cardiomyoplasty. Int J Cardiol 2004; 95(Suppl 1):S29-S33.

Chachques JC, Shafy A, Duarte F, Cattadori B, Goussef N, Shen L, Carpentier A. From dynamic to cellular cardiomyoplasty. J Cardiac Surg 2002; 17:194-200.

Chachques JC, Shafy A, Cattadori B, Duarte F, Shen L, Meimoun P, Argyriadis P, Bruneval P, Carpentier A. Electrostimulation enhanced fatigue resistant myosin expression in cellular cardiomyoplasty. Circulation 2001; 104(Suppl 2):555-556.

Monnet E, Chachques JC: Animal models of heart failure : what is new? Ann Thorac Surg 2005; 79:1445-53.

Cortes-Morichetti M, Frati G, Schussler O, Duong JP, Lauret E, Carpentier A, Chachques JC: Association of bioartificial myocardium and cellular cardiomyoplasty for myocardial support and regeneration. Circulation 2005; 112(Suppl II):II-741.

Trainini JC, Lago N, Chachques JC. La plasticidad en la regeneracion cardiaca. Rev Argent Cardiol 2005; 73:301-307.

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TRASPLANTE DE CELULAS MADRE PARA REGENERAR Y ASISTIR EL CORAZON

Título original en castellano
CARDIOMIOPLASTIA CELULAR PARA REGENERAR EL MIOCARDIO

Autor
Juan Carlos Chachques¹
1 Md, Phd, Hospital Europeo Georges Pompidou, Cirujano, Director de Investigaciones

Acceso a la fuente original
Asian Cardiovascular & Thoracic Annals
http://asianannals.ctsnetjournals.org/

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