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ANALIZAN LAS CARACTERISTICAS DE LOS EFECTOS ADVERSOS DE LOS ANTIRRETROVIRALES EN LA INFECCION POR VIH

(especial para SIIC © Derechos reservados)
Si bien la terapia antirretroviral de gran actividad ha disminuido notablemente la morbimortalidad relacionada con el VIH, el tratamiento prolongado puede ser complicado debido a los problemas que generan la adhesión y los efectos adversos.
Autor:
Erika Santos corraliza
Columnista Experto de SIIC

Institución:
Hospital Universitario

Artículos publicados por Erika Santos corraliza
Coautor
Aurelio Fuertes Martín* 
Hospital Universitario, Salamanca, España*
Recepción del artículo
14 de Mayo, 2008 		Aprobación
15 de Julio, 2008
Primera edición
27 de Marzo, 2009 		Segunda edición, ampliada y corregida
7 de Junio, 2021

ANALIZAN LAS CARACTERISTICAS DE LOS EFECTOS ADVERSOS DE LOS ANTIRRETROVIRALES EN LA INFECCION POR VIH

Resumen
La utilización de la terapia antirretroviral combinada ha mejorado el pronóstico de la infección por VIH. Estos regímenes terapéuticos han disminuido de forma significativa la morbimortalidad relacionada con el VIH en los países desarrollados. Sin embargo, el tratamiento prolongado con estas combinaciones de fármacos puede ser complicado debido a los problemas que generan la adhesión y los efectos adversos. Todos los antirretrovirales pueden producir efectos secundarios a corto y largo plazo. El riesgo de efectos adversos específicos varía según el fármaco, la clase a la que pertenece e incluso la susceptibilidad individual. El mejor conocimiento de los efectos adversos de los fármacos antirretrovirales es necesario para intentar optimizar el tratamiento en pacientes infectados por el VIH.

Palabras clave
VIH, tratamiento antirretroviral, efectos adversos, toxicidad mitocondrial, lipodistrofia


Artículo completo
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Side Effects of Antiretroviral Therapy. Fisiopathology, Clinical Manifestations and Treatment

Abstract
The use of combination antiretroviral therapy has improved the prognosis of HIV infection. These regimens have significantly decreased HIV-related morbidity and mortality in developed countries. However, prolonged treatment with combination regimens can be difficult because of problems with adherence and toxic effects. All antiretroviral drugs can have both short-term and long-term adverse events. The risk of specific side effects varies according to specific drugs, drug class and even, individual susceptibility. A better understanding of the adverse effects of antiretroviral agents is of interest to try to optimize therapy in HIV infected patients.

Key words
HIV, antiretroviral therapy, side effects, mitochondrial toxicity, lipodistrophy

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Infectología
Relacionadas: Atención Primaria, Bioquímica, Diagnóstico por Laboratorio, Farmacología, Medicina Farmacéutica, Medicina Interna



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Enviar correspondencia a:
Erika Santos Corraliza, Hospital Universitario Servicio de Medicina Interna II, 37007, Paseo de San Vicente, 58-182, Salamanca, España
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