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GEMIFLOXACINA E INFECCIONES RESPIRATORIAS EXTRAHOSPITALARIAS

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La gemifloxacina es un agente de máxima actividad antineumocócica que tiene importante actividad contra la mayoría de los neumococos resistentes a la ciprofloxacina y actividad pronunciada contra patógenos atípicos y gramnegativos.
blondeau9.jpg Autor:
Joseph m. Blondeau
Columnista Experto de SIIC
Artículos publicados por Joseph m. Blondeau
Coautor
Glenn Tillotson* 
Phd, Ffcp, Frsm, Replydine Inc, Louisville, EE.UU.*
Recepción del artículo
30 de Enero, 2007 		Aprobación
30 de Marzo, 2007
Primera edición
8 de Octubre, 2007 		Segunda edición, ampliada y corregida
7 de Junio, 2021

GEMIFLOXACINA E INFECCIONES RESPIRATORIAS EXTRAHOSPITALARIAS

Resumen
Las infecciones respiratorias bajas son una carga clínica y económica sustancial, con un costo de miles de millones de dólares anuales, a lo cual se suma otra complicación que es la resistencia creciente a los antibióticos. Esta resistencia ha comprometido la utilización de los antibióticos de uso frecuente. Se ha aprobado el uso clínico de las nuevas fluoroquinolonas como la gemifloxacina, que es caracterizada como una fluoroquinolona de doble acción con una excelente actividad contra Streptococcus pneumoniae (CIM90 0.03-0.06 μg/ml). La gemifloxacina administrada una vez al día tan sólo durante 5 días probó ser equivalente o superior a los agentes con los que se la comparó, tiene un perfil de seguridad aceptable y puede ser un agente costo-efectivo para las infecciones respiratorias bajas.

Palabras clave
infecciones extrahospitalarias del tracto respiratorio, resistencia microbiana, gemifloxacina, farmacoeconomía


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Gemifloxacin for the Management of Community-Acquired Respiratory Tract Infections

Abstract
Lower respiratory tract infections are a substantial clinical and financial burden costing billions annually. A further complication is antimicrobial resistance among key pathogens, such as Streptococcus pneumoniae. Such resistance has compromised the use of commonly used antimicrobial compounds and influences treatment options in both the outpatient and inpatient environments. New fluoroquinolones have been introduced to meet these new demands; however, recent resistance to older compounds is a concern. Gemifloxacin is the newest to be approved for clinical use and is characterized as a potent dual-acting fluoroquinolone with excellent activity against S. pneumoniae (MIC90 0.03-0.06 μg/ml) including those demonstrating resistance to other agents including quinolones (MIC90 0.12-0.5 μg/ml). Gemifloxacin has proven equivalent to, or superior to, comparator agents in clinical trials, has an acceptable safely profile, and will likely be a cost-effective alternative for community-acquired lower respiratory tract infections including those caused by resistant pathogens.

Key words
community respiratory tract infections, antimicrobial resistance, gemifloxacin, health economics


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Especialidades
Principal: Neumonología
Relacionadas: Atención Primaria, Farmacología, Infectología, Medicina Interna, Pediatría



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Enviar correspondencia a:
Joseph M. Blondeau, Department of Clinical Microbiology, Royal University Hospital , S7N 0W8, 103 Hospital Drive, Saskatoon, Canadá
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