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NUEVAS TERAPIAS EN LA ESCLEROSIS MULTIPLE

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Las terapias actuales de la esclerosis múltiple son principalmente efectivas como profilaxis en el estadio de recaídas y remisiones de la enfermedad, mientras que las terapias más agresivas que parecen ser beneficiosas en el estadio progresivo tienen sólo un beneficio limitado y una toxicidad importante. El neurólogo general individualiza en la actualidad las recomendaciones de la terapia combinada para una indicación aún no autorizada, a menudo en consulta con un especialista en esclerosis múltiple.
yeh9.jpg Autor:
Ann e. Yeh
Columnista Experto de SIIC
Artículos publicados por Ann e. Yeh
Coautor
Bianca Weinstock-Guttman* 
MD, State University of New York, Buffalo, EE.UU.*
Recepción del artículo
14 de Diciembre, 2006 		Aprobación
7 de Febrero, 2007
Primera edición
21 de Agosto, 2007 		Segunda edición, ampliada y corregida
7 de Junio, 2021

NUEVAS TERAPIAS EN LA ESCLEROSIS MULTIPLE

Resumen
La esclerosis múltiple (EM) es una enfermedad inflamatoria autoinmune caracterizada por desmielinización y pérdida axonal en el sistema nervioso central. Desde la última década se encuentran disponibles nuevas terapias inmunomoduladoras como el interferón beta y el acetato de glatiramer. No obstante, estas terapias son sólo parcialmente efectivas. Existe una necesidad continua de formular estrategias terapéuticas más efectivas para combatir los aspectos crónicos y progresivos de la enfermedad. Dada la compleja fisiopatología subyacente al proceso patológico de la EM, la terapia combinada ofrece un abordaje terapéutico racional. Independientemente de la estrategia terapéutica empleada, la intervención temprana seguirá siendo el factor de mayor importancia.

Palabras clave
esclerosis múltiple, terapias combinadas, interferón, acetato de glatiramer, natalizumab


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New Combination Therapies for Multiple Sclerosis

Abstract
Multiple sclerosis (MS) is an inflammatory autoimmune disease characterized by demyelination and axonal loss in the central nervous system. Although new immunomodulatory therapies including interferon beta and glatiramer acetate became available during the last decade these therapies are only partially effective. There is a continuing need to develop more effective treatment strategies to combat the chronic and progressive aspects of the disease. In view of the complex pathophysiology underlying the MS disease process, combination therapy offers a rational therapeutic approach. Regardless of the treatment strategy to be employed, early intervention will remain the most important factor.

Key words
multiple sclerosis, combination therapies, interferon, glatiramer acetate, natalizumab


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Especialidades
Principal: Neurología
Relacionadas: Bioética, Farmacología, Medicina Farmacéutica, Medicina Interna



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Bianca Weinstock-Guttman, The Jacobs Neurological Institute, NY 14203, 100 High Street, Suite E-2, Buffalo, EE.UU.
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