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CONTROVERSIAS ACERCA DE LA TEORIA TH2 EN ALERGIA

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El desarrollo de bloqueadores de moléculas coestimuladoras parece ser un campo promisorio, al igual que el de los receptores de las células tipo toll, además de los componentes genéticos que confieren susceptibilidad a la producción de citocinas tipo Th2.
rojasra9.jpg Autor:
Rojas ramos, enrique
Columnista Experto de SIIC

Institución:
Departamento de Inmunología Clínica y Alergia Hospital Regional 1º de Octubre Instituto de Seguridad Social al Servicio del Estado (ISSSTE) México DF, México

Artículos publicados por Rojas ramos, enrique
Coautores
Norma E. Martínez Jimúnez, MD, MSc*  María de Lourdes García Moreno, MD*  Carlos Colin Núñez, MD* 
ISSSTE*
Recepción del artículo
13 de Septiembre, 2004 		Aprobación
1 de Octubre, 2004
Primera edición
3 de Marzo, 2005 		Segunda edición, ampliada y corregida
7 de Junio, 2021

CONTROVERSIAS ACERCA DE LA TEORIA TH2 EN ALERGIA

Resumen
Los padecimientos alérgicos han sido un modelo de estudio para la polarización de células Th2 y es bien sabido que la síntesis de la IgE humana surge de la colaboración entre las células Th2 y las células B a través de la participación de citocinas como la IL-4 y la IL-13 y moléculas de superficie como CD40-CD40L. En la última década, algunas moléculas de superficie han sido asociadas con células Th2 humanas. Aunque estudios recientes sugieren que los receptores de quimiocinas son los marcadores más relacionados con células Th2, hasta la fecha no se encontró un marcador específico para las células Th2. Los estudios más recientes sugieren, en primer término, que las células Th1 y Th2 no son derivadas de distintos linajes celulares sino que pueden derivarse del mismo precursor Th y, bajo la influencia de factores genéticos y medioambientales, polarizarse y convertirse en células Th1, Th2 y las llamadas Th3 o reguladoras. Por otro lado, el desarrollo de bloqueadores de moléculas coestimuladoras parece ser un campo promisorio, al igual que el de los receptores de las células tipo toll, además de los componentes genéticos que confieren susceptibilidad a la producción de citocinas tipo Th2.

Palabras clave
Alergia, teoria Th2, citocinas, marcadores de superficie, genes


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Especialidades
Principal: Alergia
Relacionadas: Atención Primaria, Bioquímica, Diagnóstico por Laboratorio, Inmunología, Medicina Interna



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Bibliografía del artículo
  1. Hjerm A, Haglud B, Hedlin G. Ethnicity, childhood environment and atopic disorder. Clin Exp Allergy 2000;30:521-528.
  2. Virant SF. Allergic Rhinitis. Immunol Allergy Clin North Am 2000;2:265-282.
  3. Woolcock AJ, Peat JK. Evidence for the increase in asthma world wide. Ciba Found Symp 1997;206:122-134.
  4. Shamissain MH, Shamsian N. Prevalence and severity of asthma, rhinitis, and atopic eczema in 13 to 14 year old schoolchildren from the northeast of England. Ann Allergy Asthma Immunol 2001:86:428-432.
  5. Hessel PA, Klaver J, Michaelchuck D, McGhan S, Carson MM, Melvin D. The epidemiology in childhood asthma in red deer and medicine hat, Alberta. Can Respir J 2001;8:139-146.
  6. McNally N, Phillips DR, Williams HC. The problem of atopic eczema: aetiological clues from the environmental and lifestyles. Soc Eci Med 1998;46:729-741.
  7. Romagnani S. Regulation and deregulation of human IgE synthesis. Immunol Today 1990;11:316-319
  8. Vercelli D, Geha RS. Regulation of IgE synthesis in humans: a tale of Two signals. J Allergy Clin Immunol 1991;88:285-291.
  9. Del Prete GF, Maggi E, Parrochi P, Chretien I, Tiri A, Macchia D, Ricci M, Banchhereau J, de Vries J, Romagnani S. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatansts. J Immunol 1988;140:4193-4197.
  10. Pene JF, Rouset F, Briere F, Chretien I, Bonnefoy JY, Spits H, Yokota T, Arai N, Arai KI, Banchereau J, de Vries J. IgE Production by normal human lymphocytes is induced by interleukin 4 and supressed by interferons- and a prostaglandin E2. Proc Natl Acad Sci USA 1988;85:6880-6886.
  11. Jabara HH, Fu SM, Geha RS, Vercelli D. CD40 and IgE: synergism beetween anti CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J Exp Med 1990; 172:1861-1866.
  12. Gauchat JF, Lebman DA, Coffman RL, Gascan H, de Vires JE. Structure and expression of germline transcripsts in human B cells induced by interleukin 4 to switch to IgE production. J Exp Med 1990;172:463-466.
  13. Herzog RW, Dobrzynski E, Mammen EF, Van den Driessche T, Chuah M Kl. Immune implications of gene therapy for hemophilia. Sem Tromb Hemostasis 2004; 30:215-226.
  14. Weiner H L. Induction and mechanism of action of transforming growth factor beta secreting Th3 regulatory cell. Immunol Rev 2001; 182:207-214.
  15. Punnonen J, Aversa G, Coks BG, McKenzie ANJ, Menon S, Zurawski G, De Waal Malefyt R, De Vries JE. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993;90:3730-3735.
  16. Parronchi P, Tiri A, Macchia D, De Carli M, Biswas P, Simonelli C, Maggi E, Del Prete GF, Ricci M, Romagnani S. Noncognate contact-dependent B cells activation can promote IL-4 dependent in vitro human IgE synthesis. J Immunol 1990;144:2102-2109.
  17. Vercelli D, Jabara HH; Arai K, Geha RS. Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/ CD3 complex and MHC Class II antigens. J Exp Med 1989;169:1295-1299.
  18. Kay AB, Yin S, Varney V, Gaga M, Durham SR, Moqbel R, Wardlaw AJ, Hamid Q. Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3, IL-4, IL-5 and granulocyte/macrophage colony-stimulating factor, in allergen-induced late phase cutaneous reactions in atopic subjects. J Exp Med 1991;173:775-779.
  19. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone I. Definitions according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-2352.
  20. Del Prete GF, Tiri A, De Carli M, Macchia D, Parronchi P, Rossi ME, Pietrogrande MC, Ricci M, Romagnani S. Defective in vitro production of interferon-gamma and tumor necrosis factor-alpha by circulating T cells from patients with hyper-IgE syndrome. J Clin Invest 1989;84:1830-1834.
  21. Romagnani S, del Prete GF, Maggi E, Parronchi P, Tiri A, Macchia D, Giudizi MG, Almerigogna F, Ricci M. Role of interleukins in induction and regulation of human IgE synthesis. Clin Immunol Immunophatol 1989;50:13-19.
  22. Del Prete GF, De Carli M, D’ Elios MM, Maestrelli P, Ricci M, Fabri L, Romagnani S. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergy respiratory disorders. Eur J Immunol 1993,23:1445-1449.
  23. Hamid Q, Azzawi M, Ying S, Moqbel R, Waedlaw AJ, Corrigan CJ, Bradley B, Durham SR, Collins JV, Jefrey PK,Quint DJ, Kay AB. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991;87:1541-1546.
  24. Maggi E, Biswas P, Del Prete GF, Parronchi P, Macchia D, Simonelli C, Emmi L, De Carli M, Tiri A, Ricci M, Romagnani S. Accumulation of Th2 like helper T cells in the conjunctiva of patients with vernal conjunctivitis. J Immunol 1991;146:1169-1172.
  25. Van der Heijden FL, Wierenga EA, Bos JD, Kapsenberg ML. High frequency of IL-4 producing CD4+ allergen-specific T lymphocytes in atopic dermatitis lesional skin. J Ivest Dermatol 1991;97:389-394.
  26. KleiJan A, Dijstra M, Boks S, Severijnen L, Mulder P, Fokkens W. Increased IL-8, IL-10, IL-13 and RANTES mRNA levels (in situ hybridization in the nasal mucosa after allergen provocation) J Allergy Clin Immunol 1999;103:441-450.
  27. Robinson DS, Hamid Q, Ying S, Tsicopulus A, Barkan J, Bentley AM, Corrigan C, Durham SR, Kay AB. Predominant Th2-like broncholaveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-302.
  28. Romagnani S. Human Th1 and Th2: Doubt no more. Immunol Today 1991:12:256-259.
  29. Parronchi P, De Carli M, Manetti R, Simonelli C, Piccinni MP, Macchia D, Maggi E, Del Prete GF, Ricci M, Romagnani S. Aberrant interleukin (IL-4) and IL-5 production in vitro by CD4+ helper T cells from atopic subjects. Eur J Immunol 1992,22:1615-1619.
  30. Seder R, Paul WE, Davis MM, Fazekas de St. Grouth B. The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential CD4+ T cells from T-cell receptor transgenic mice. J Exp Med 1992:176;1091.
  31. Durkop H, Latza U, Hummel M, Eitelbach F, Seed B, Stein H. Molecular cloning and expression of a new member of the nerve growth factor receptor family wich is characteristic for Hoddking’s disease. Cell 1992;68:1128-1132.
  32. Josimovic-Alsevic O, Durkop H, Schwarting REB, et al. Ki-1 (CD30) antigen is released by Ki-1-positive tumor cells in vitro and in vivo, I. Partial characterization of soluble Ki-1 and detection of the antigen in cell culture supernatants and in serum by an enzyme-linked immunosorbent assay. Eur J Immunol 1998:19;157-162.
  33. Romagnani S, Del Prete G, Maggi E, Chilosi M, Caligaris-Cappio F, Pizzolo G. CD30 and type 2 T helper (Th2) responses. J Leukoc Biol 1995;57:726-730.
  34. Parronchi P, De Carli M, Manetti R, Simonelli C, Piccini MP, Macchia D, Maggi E, Del Prete GF, Ricci M, Romagnani S. Aberrant interleukin (IL)-4 and IL-5 production in vitro by Cd4+ helper T cells from atopic subjets. Eur J Immunol 1993;22:1615-1619.
  35. Del Prete GF, De Carli M, Almerigogna F, Daniel CK, D’Elios MM, Zancuoghi G, Vinante F, Pizzolo G, Romagnani S. Preferential expression of CD30 by human CD4+ T cells producing Th2 type cytokines. FASEB J 1995;9:81-86.
  36. Maggi E, Parronchi P, Manetti R, Simonelli C, Piccini MP, Santoni-Rugiu F, De Carli M, Ricci M, Romagnani S. Reciprocal regulatory role of IFN and IL-4 on the in vitro development of human Th1 and Th2 cells. J Immunol 1992;148:2142-2146.
  37. Leonard C, Tormey V, Faul J, Burke CM, Poulter LW. Allergen-induced CD30 expression on T cells of atopic asthmatics. Clin Exp Allergy. 1997;27:780-786.
  38. Pretkova D, Xaubet A, Picado C, Fillela X, Agusti C, Luburich P, Rodriguez-Roisin R. Evaluation of CD30 as a marker for Th2 lympocytes in brochoalveolar lavage in interstitial lung disease. Respir Med 2000;94:345-349.
  39. Dummer W, Rose C, Brocker EB. Expression of CD30 on T helper cells in the inflammatory infiltrate of acute atopic dermatitis but not of allergic contact dermatitis. Arch Dermatol Res 1998:290;598-602.
  40. Nakamura T, Lee RK, Nam SY, Al-Ramadi BK, Bottomly K, Podak ER, Flavell RA. Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma. J Immunol 1997;158:2090-2098.
  41. Dummer W, Rose C, Brocker EB. Expression of CD30 on T helper cells in the inflammatory infiltrate of acute atopic dermatitis but not of allergic contact dermatitis. Arch Dermatol Res 1998:290;598-602.
  42. Dummer W, Brocker EB, Bastian BC. Elevated serum levels of soluble CD30 are associated with atopic dermatitis, but not with respiratory atopic disorders and allergic contact dermatitis. Br J Dermatol 1997:137;185-187.
  43. Dummer W, Rose C. Brocker EB. Expression of CD30 on T helper cells in the inflammatory infiltrate of acute atopic dermatitis but not of allergic contact dermatitis. Arch Dermatol Res 1998:290;598-602.
  44. Begtsson A, Holm L, Back O, et al Elevated serum levels of soluble CD30 in patients with atopic dermatitis. Clin Exp Immunol 1997:109;533-537.
  45. Yamamoto JY, Onoue YA, Kanegane H, et al. CD30 expression on circulating memory CD4+ T cells as a Th2-dominated situation in patients with atopic dermatitis. Allergy 2000;55:1011-1018.
  46. Petkova D, Xaubet A, Picado C, Filella X, Agusti C, Luburich P, Rodriguez-Roisin R. Evaluation of CD30 as a marker for Th2 lymphocytes in bronchoalveolar lavage in interstitial lung diseases. Respir Med 2000;94:345-349.
  47. Biswas P, Rovere P, Filippi C, Heltai S, Smith C, Dagna L, Poli G, Manfredi A, Ferrarini M. Engagement of CD30 shapes the secretion of cytokines by human T cells. Eur J Immunol 2000;30:2172-2180.
  48. Muta H, Boise LH, Fang L, Podack ER. CD30 signals integrate expression of cytotoxic effector molecules, lymphocytes trafficking, and signals for proliferation and apoptosis. J Immunol 2000;165:5105-5111.
  49. Gerli R, Lunardi C, Vinante F, Bistoni O, Pizzolo G, Pitzalis C. Role of CD30+ T cells in rheumatoid arthritis: a counter regulatory paradigm for Th1 driven diseases. Trends Immunol 2001;22:72-77.
  50. Li XD, Essayan DM, Liu MC, Beaty TH, Huang SK. Profiling of differential gene expression in activated, allergen specific Th2 cells. Genes Immun 2001;2:88.
  51. Kanegane HY, Kasahara Y, Niida Y, Yachie A, Suggi S, Takatsu K, Taniguchi N, Miyawaki T. Expression of L-selectin (CD62L) discriminates Th1-and Th2-like cytokine-producing memory CD4+ T cells. Immunology 1996;87:186-190.
  52. Yammashita H, Tanno Y. Expression of L-selectin on peripheral memory CD4+ T cells in atopic diseases. Arerugi 1998;47:1168-1175.
  53. Mitra DK, De Rosa SC, Luke A, Balamurugan A, Khaitan BK, Tung J, Mehra NK, Terr AI, O’Garra A, Herzenberg LA, Roederer M. Differential representations of memory T cell subsets are characteristic of polarized immunity in leprosy and atopic diseases. Int Immunol 1999;11:1801-1810.
  54. Gerber GO, Zanni M, Uguccioni M, Mackay CR, Pichler WJ, Yawalkar N, Baggiolini M, Moser B. Functional expression of eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils. Current Biology 1997;7:836-843.
  55. Campbell JD, Hay Glass KT. T cell chemokine receptor expression in human Th1 and Th2 associated diseases. Arch Immunol Ther Exp 2000;48;451-456.
  56. Annunziato F, Galli G, Cosmi L, Romagnani P, Mannetti R, Maggi E, Romagnani S. Molecules Associated with human Th1 or Th2 cells. Eur Cytokine Netw 1998;9:12-16.
  57. Annunziato F, Cosmi L, Galli G, Beltrame C, Romagnani P, Manetti R, Romagnani S, Maggi E. Assessment of chemokine receptor expresion by human Th1 and Th2 in vitro and in vivo. J Leukoc Biol 1999;65:691-699.
  58. Cosmi L, Annunciziato F, Galli MIG, Maggi RME, Nagata K, Romagnani S. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur J Immunol 2000;30:2972-2972.
  59. Romagnani S. The Th1/Th2 Paradigm. Immunol Today 1997;18: 263-266.
  60. Rossi G, Sarkar J. Scandella D. Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A. Blood 2001; 97:2750- 2757.
  61. Moverare R, Elfman L, Stalenheim G, Bjornsson E. Study of the Th1/Th2 balance, including IL-10 production, in cultures of peripheral blood mononuclear cells from birch-pollen-allergic patients. Allergy 2000;55:171-175.
  62. Romagnani S. Regulation of the development of type 2 T-helper cells in allergy. Curr Opin Immunol 1994;6:838.
  63. Cosmi L, Annunziato F, Maggi E, Romagnani S manetti R. Chemoattractant receptors expressed on type 2 T cells and their roll in disease. Int Arch Allergy Immunol 2001;125:273-279.
  64. Shelburne CP, Ryan JJ. The role of Th2 cytokines in mast cell homeostasis. Immunol Rev 2001;179:82-93.
  65. Lensmar C, Prieto J, Dahlén B, Eklund A, Grunewald J, Roquet A. Airway inflammation and altered alveolar macrophage phenotype pattern after repeated low-dose allergen exposure of atopic asthmatic subjects. Clin. Exp. Allergy 1998; 29:1632-1640.
  66. Moffat M, Cookson W. Genetics of asthma and inflammation: the status. Curr. Op. Immunol. 1999;11:606-609.
  67. Lensmar C, Prieto J, Dahlén B, Eklund A, Grunewald J, Roquet A. Airway inflammation and altered alveolar macrophage phenotype pattern after repeated low-dose allergen exposure of atopic asthmatic subjects. Clin. Exp. Allergy 1998; 29:1632-1640.
  68. Shelburne CP, Ryan JJ. The role of Th2 cytokines in mast cell homeostasis. Immunol Rev 2001;179:82-93.
  69. Aarvak T, Strand E, Teigland J, Miossec P, Natving JB. Swtch in chemokine receptor phenotype on memory on memory T cells without a change in cytokine phenotype. Scand J Immunol 2001;54:100-108.
  70. Abi-Younes S, Si-Tahar M, Luster AD. The CC chemokines MCD and TARC induce platelet activation via CCR4. Thromb Res 2001;101:279-289.
  71. Bayscal C, Atilgan AR. Elucidating the structural mechanisms for biological activity of the chemokine family. Proteins 2001;43:150-160.
  72. Lellem A, Colantonio L,Bhakta S, Sozzani S, Mantovani A, Sinigaglia F, D’Ambrosio D. Inhibition by IL-12 and IFN-alpha and macrophage derived chemokine production upon TCR triggering of human Th1 cells. Eur J Immunol 2000;30:1030-1039.
  73. D’Ambrosio D, Lellem A, Colantonio L, Clissi B, Pardi R, Sinigaglia F. Localization of Th cell subsets in inflammation: differential thresholds for extravasations of Th1 and Th2 cells. Immunol Today 2000;105:399-408.
  74. Hagel I, Di Prisco M C. Goldblatt J. Le Souef P N. The role of parasites in Genetic Susceptibility to Allergy: IgE, Helmintic Infection and the evolution of the Human Immune System. Clin Rev Allergy Immunol. 2004; 26:75-84.
  75. Whary MT, Fox JG. Th1 mediated pathology in mouse models of human diseases is ameliorated by concurrent Th2 responses to parasite antigens. Curr Top Med Chem; 2004; 4:531-8.
  76. Gangloff S C. Guenounou M. Toll- Like receptors and Immune Response in Allergic Disease. Clin Rev Allergy Immunol. 2004; 26:115-126.
  77. Prescott S, Macaubas C, Smallacombe T, Holt B, Sly P, Holt P. Development of allergen-specific T-cell memory in atopic and normal children. Lancet. 1999,353:196-200.
  78. Berin CM, Eckman L, Broide DH, Kagnoff MF. Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts. Am J Respir Cell Mol Biol 2001;24:382-389.
  79. Terada N, Hamano N, Kim WJ, Hirai K, Kakajima T, Yamada H, Kawasaki H, Yamashita T, Kishi H, Nomura T, Numata T, Yoshie O, Konno A. The kinetics of allergen-induced eotaxin level in nasal lavage fluid its key role in eosinophil recruitment in nasal mucosa. Am J Crit Care Med 2001;164:575-579.
  80. Fernandez EJ, Wilken J, Thompson DA, Peiper SC, Lolis E. Comparison of the structure of vMIP-II with eotaxin-1 RANTES, and MCP-3 suggest a unique mechanism for CCR3 activation. Biochemistry 2000;34:12837-12844.
  81. Palmer L, Cookson WO, Genomic approaches to understanding asthma. Genome Res 2000;10:1280-1287.
  82. Bellinghausen I, Brand U, Enk A, Knop J, Saloga J. Signals involved in the early Th1/Th2 polarization of an immune response depending on the type of antigen. J allergy Clin Immunol 1999;103:298-306.
  83. McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuckroo VK, Barsh GS, Freeman JG, Umetsu DT, DeKruyff RH. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nature Immunology 2001;2:1109-1116.
  84. Karp MW. Asthma genetics: not for the Timid. Nature Immunology 2001;2:1095-1096.
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