Expertos Invitados





PROPIEDADES QUIMIOPREVENTIVAS DEL MANGO Y LA MANZANA EN EL CANCER DE COLON

(especial para SIIC © Derechos reservados)
La identificación de alimentos de origen vegetal, como el mango y la manzana, así como sus constituyentes con propiedades anticancerígenas, es una alternativa posible para el control, la prevención y el tratamiento de una neoplasia frecuente como el cáncer de colon.
Autor:
Maria elena Maldonado
Columnista Experta de SIIC

Institución:
Universidad de Antioquia

Artículos publicados por Maria elena Maldonado
Aprobación
1 de Agosto, 2012 		Primera edición
26 de Febrero, 2013 		Segunda edición, ampliada y corregida
7 de Junio, 2021

PROPIEDADES QUIMIOPREVENTIVAS DEL MANGO Y LA MANZANA EN EL CANCER DE COLON

Resumen
El cáncer de colon es uno de los más frecuentes en el mundo y una de las principales causas de mortalidad por cáncer. El hallazgo epidemiológico del papel protector de frutas contra el cáncer propone que fitoquímicos presentes en estos alimentos pueden ser responsables de la disminución del riesgo. Actualmente, se avanza en la identificación de más y nuevos compuestos naturales o alimentos con propiedad quimiopreventiva, capaces de interferir en las primeras etapas de la carcinogénesis, evitar la aparición de lesiones preneoplásicas y limitar la aparición de nuevas células tumorales. Los agentes quimiopreventivos se clasifican en bloqueadores de la iniciación y supresores de la promoción o progresión, dentro de los cuales se encuentran componentes de las frutas mango (Mangifera indica) y manzana (Malus sp., rosacea) como ácido ascórbico, carotenoides, mangiferina, quercetina, pectina y procianidinas. Los extractos, fracciones enriquecidas con estos fitoquímicos o jugos son capaces de influenciar diferentes mecanismos importantes para prevenir el cáncer de colon en estudios in vitro, algunos validados en modelos in vivo. Estos incluyen actividad antioxidante, modulación de vías de transducción de señales, del metabolismo de poliaminas, algunos eventos epigenéticos, antiproliferación, alteración o bloqueo del ciclo celular, apoptosis y disminución de lesiones preneoplásicas en modelos animales.

Palabras clave
Mangifera indica, Malus spp., quimioprevención, cáncer de colon, polifenoles


Artículo completo
(castellano)
Extensión:  +/-8.86 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

Chemopreventive properties of mangoes and apples in colon cancer

Abstract
Colon cancer is one of the most common forms of cancer worldwide and one of the leading causes of cancer mortality. Epidemiological findings of the protective effect of fruits on cancer suggest that phytochemical compounds of fruits may reduce the risk of developing cancer. Many researches currently in progress are identifying more and new natural compounds of fruits as chemopreventive agents able to interfer in the early stages of carconogenesis, prevent pre-neoplasic lesions and reduce development of neoplasic cells. Chemopreventive agents have been classified as cancer-blocking agents of initiation stage and cancer-supressing agents of promotion and/or progression stages, involving phytochemical mango (Mangifera indica) and apple (Malus sp., Rosacea) compounds such as ascorbic acid, carotenoids, mangiferin, quercetin, pectin and procyanidins. In vitro studies have shown that extracts, phytochemical enriched-fractions or juice are able to influence relevant mechanisms for preventing colon cancer, some of them confirmed by using in vivo colon cancer models. These mechanisms involve anti-oxidant, signal transduction pathways, polyamines metabolism, epigenetic, anti-proliferation, cell cycle arrest, apoptosis effects, and reduction of pre-neoplasic lesions in animal models.

Key words
Mangifera indica, Malus spp., chemoprevention, colon cancer, polyphenols

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Bioquímica, Nutrición
Relacionadas: Anatomía Patológica, Gastroenterología, Inmunología, Oncología, Salud Pública



Comprar este artículo
Extensión: 8.86 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra



Enviar correspondencia a:
Maria Elena Maldonado Celis, Escuela de Nutrición y Dietética, Universidad de Antioquia, Ciudadela de Robledo. Carrera 75 # 65-87. Bloque 44, oficina 107., Medellín, Colombia
Patrocinio y reconocimiento:
Este trabajo (Proyecto 46-1-390) se deriva del apoyo del Programa de Sostenibilidad de la Vicerrectoría de Investigación de la Universidad de Antioquía, que recibió el Grupo de Alimentación y Nutrición Humana CC9889E01454 (2009-2011).
Bibliografía del artículo
1. González CA, Pera G, Agudo A, y col. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EUGAST). Int J Cancer 118:2559-2566, 2006.
2. Jansen MC, Bueno de Mesquita HB, Feskens EJ, Streppel MT, Kok FJ, Kromhout D. Quantity and variety of fruit and vegetable consumption and cancer risk. Nutr Cancer 48:142-148, 2004.
3. Vainio H, Weiderpass E. Fruit and vegetables in cancer prevention. Nutr Cancer 54:111-142, 2006.
4. Van Breda SGJ, De Kok TMCM, Van Delft JHM. Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach. J Nutr Biochem 19:139-157, 2008.
5. World Health Organisation (WHO). World Cancer Report. Lyon: International Agency for Research on Cancer, 2003.
6. World Cancer Research Fund/American Institute for Cancer Research Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington DC: International Agency for Research on Cancer, 2007.
7. Gossé F, Guyot S, Roussi S, y col. Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis 26:1291-1295, 2005.
8. Maldonado-Celis ME, Roussi S, Foltzer-Jourdainne C, y col. Modulation by polyamines of apoptotic pathways triggered by procyanidins in human metastatic SW620 cells. Modulation by polyamines of apoptotic pathways triggered by procyanidins in human metastatic SW620 cells. Cell Mol Life Sci 65:1425-1434, 2008.
9. Maldonado-Celis ME, Raul F. Pro-apoptotic effects of apple procyanidins in human colon cancer cells and their derived metastatic cells. Vitae 17:337-347, 2010.
10. Ramos S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nut Biochem 18:427-442, 2007.
11. Russo GL. Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 74:533-544, 2007.
12. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768-780, 2003.
13. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 55:74-108, 2005.
14. Labianca R, Beretta GD, Kildani B, y col. Colon cancer. Crit Rev Oncol Hematol 74:106-133, 2010.
15. Winawer SJ. Natural history of colorectal cancer. Am J Med 106:3S-6S; discussion 50S-51S, 1999.
16. Hill MJ, Morson BC, Bussey HJ. Aetiology of adenoma-carcinoma sequence in large bowel. Lancet 1:245-247, 1978.
17. Renehan AG, O'Dwyer ST, Haboubi NJ, Potten CS. Early cellular events in colorectal carcinogenesis. Colorectal Dis 4:76-89.
18. Vogelstein B, Fearon ER, Hamilton SR, y col. Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532, 1988.
19. Cho KR, Vogelstein B. Genetic alterations in the adenoma-carcinoma sequence. Cancer 70:1727-1731, 1992.
20. Robbins DH, Itzkowitz SH. The molecular and genetic basis of colon cancer. Med Clin North Am 86:1467-1495, 2002.
21. Bisgaard ML, Fenger K, Bulow S, Niebuhr E, Mohr J. Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate. Hum Mutat 3:121-125, 1994.
22. Sporn MB. Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res 36:2699-2702, 1976.
23. Manson M. Cancer prevention the potential for diet to modulate molecular signaling. Trends Mol Med 9:11-18, 2003.
24. Wattenberg LW. Chemoprevention of cancer. Cancer Res 45:1-8, 1985.
25. Johnson IT. Phytochemicals and cáncer. Proc Nutr Soc 66:207-215, 2007.
26. Kok TH, Van Breda SG, Manson MM. Mechanisnm of combined action of different chemopreventive dietary compounds. Eur J Nutr 47:51-59, 2008.
27. Scalbert A, Manach C, Morand C, Rémésy C, Jiménez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45:287-306, 2005.
28. Araujo Jr, Goncalves P, Martel F. Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr Res 31:77-87, 2011.
29. Johnson PF. Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci 118:2545-2555, 2005.
30. Kim H, Kim EH, Eom YW, y col. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Cancer Res 66:1740-1750, 2006.
31. Lauber K, Blumenthal SG, Waibel M, Wesselborg S. Clearance of apoptotic cells: getting rid of the corpses. Mol Cell 14:277-287, 2004.
32. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68:383-424, 1999.
33. Kaufmann SH, Steensma DP. On the TRAIL of a new therapy for leukemia. Leukemia 19:2195-2202, 2005.
34. www.asohofrucol.com.co.
35. Parrotta JA. Mangifera indica L. Mango. SO-ITF-SM-63. New Orleans, LA: U.S. Department of Agriculture, Forest Service, Southern Forest Experiment Station, 1993.
36. Corporación Colombiana Internacional. Cultivo del Mango en Colombia. [internet] [Consultado 2011 sept 20 11]. Disponible en: http://www.cadenahortofruticola.org/admin/bibli/481agroecologia_cosecha_mango_2.pdf.
37. Origin, history of cultivation. University of Georgia. Archived from the original on 21 January 2008. [Consultado 2008 enero 21]. Disponible en: http://web.archive.org/web/20080121045236/http://www.uga.edu/fruit/apple.html.
38. Elzebroek ATG, Wind K. Guide to cultivated plants. Wallingford, USA: CAB International, 2008.
39. Ribeiro SMR, Schieber A. Bioactive compounds in mango (Mangifera indica L.). En: Watson R, Preedy V (Eds). Bioactive foods in promoting health. California: Academic Press, pp. 507-523, 2010.
40. Ribeiro SMR. Mango (Mangifera indica L.) antioxidant potential: characterization and evaluation. [Thesis Doctor Science]. Brazil: Department of Molecular Biology and Biochemistry. Federal University of Vicosa.
41. Leterme P, Buldgen A, Estrada F, Londono AM. Mineral content of tropical fruits and unconventional foods of the Andes and the rain forest of Colombia. Food Chem 95:644-652, 2006.
42. Ribeiro SMR, Queiroz JH, Lopes MELR, Milagres FC, Pinheiro-Sant'Ana HM. Antioxidant in mango (Mangifera indica L) pulp. Plant Foods Hum Nutr 62:13-17, 2007.
43. Guyot S, Marnet N, Sanoner P, Drilleau JF. Variability of the polyphenolic composition of cider apple (Malus domestica) fruits and juices. J Agric Food Chem 51:6240-6247, 2003.
44. Lata B, Przeradzka M, Binkowska M. Great differences in antioxidant properties exist between 56 apple cultivars and vegetation seasons. J Agric Food Chem 53:8970-8978, 2005.
45. Percival SS, Talcott ST, Chin ST, Mallak AC, Lounds-Singleton A, Pettit-Moore J. Neoplastic transformation of BALB/3T3 cells and cell cycle of HL-60 cells are inhibited by mango (Mangifera indica L.) juice and mango juice extracts. J Nutr 136:1300-1304, 2006.
46. Noratto GD, Bertoldi MC, Krenek K, Talcott ST, Stringheta PC, Mertens-Talcott SU. Anticarcinogenic effects of polyphenolics from mango (Mangifera indica) varieties. J Agric Food Chem 58:4104-4112, 2010.
47. Weber P, Bendich A, Schalch W. Vitamin C and human health - a review of a recent data relevant to requirements. Int J Vitam Nutr Res 66:19-30, 1996.
48. Tannenbauen SR, Wishnok JS, Leaf CD. Inhibition of nitrosamine formation by ascorbic acid. Am J Clin Nutr 53:247S-250S, 1991.
49. Connelly AE, Satia-About J, Martin CF, y col. Vitamin C intake and apoptosis in normal rectal epithelium. Cancer Epidemiol Biomarkers Prev 12:559-565, 2003.
50. An SH, Kang JH, Kim DH, Lee MS. Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells. BMB Rep 44:211-216, 2011.
51. Boateng J, Verghese M, Shackelford L, y col. Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats Food Chem Toxicol 45:725-732, 2007.
52. Lauretani F, Semba RD, Bandinelli S, y col. Carotenoids as protection against disability in older persons. Rejuvenation Res 11:557-563, 2008.
53. El Ansari MA, Reddy KK, Sastry KNS, Nayudamma Y. Polyphenols of Mangifera indica. Phytochem 10:2239-2241, 1971.
54. Sinicrope FA, Gill S. Role of cyclooxygenase-2 in colorectal cancer. Cancer Metastasis Rev 23:63-75, 2004.
55. Burri JB. Carotenoids and gene expression. Nutrition 16:577-578, 2000.
56. García-Rivera D, Delgado R, Bougarne N, Haegeman G, Berghe WV. Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells. Cancer Lett 305:21-31, 2011.
57. Yoshimi N, Matsunaga K, Katayama M, et al. The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats. Cancer Lett 163:163-170, 2011.
58. Friedrich D, Teller N, Esselen M, Pahlke G, Marko D. Comparison of delphinidin, quercetin and (-)-epigalloca-techin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation. Mol Nutr Food Res 52:815-822, 2008.
59. Kim HJ, Kim SK, Kim BS, y col. Apoptotic effect of quercetin on HT-29 colon cancer cells via the AMPK signaling pathway. J Agric Food Chem 58:8643-8650, 2010.
60. Pohl C, Will F, Dietrich H, Schrenk D. Cytochrome P450 1A1 expression and activity in Caco-2 cells: modulation by apple juice extract and certain apple polyphenols. J Agric Food Chem 54:10262-10268, 2006.
61. Veeriah S, Kautenburger T, Habermann N, y col. Apple flavonoids inhibit growth of HT29 human colon cancer cells and modulate expression of genes involved in the biotransformation of xenobiotics. Mol Carcinog 45:164-174, 2006.
62. D'Angelo S, Cimmino A, RaimoM, Salvatore A, Zappia V, Galletti P. Effect of reddening-ripening on the antioxidant activity of polyphenol extracts from cv. `Annurca' apple fruits. J Agric Food Chem 55:9977-9985, 2007.
63. Kern M, Pahlke G, Balavenkatraman KK, Bohmer FD, Marko D. Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. J Agric Food Chem 55:4999-5006, 2007.
64. Veeriah S, Hofmann T, Glei M, y col. Apple polyphenols and products formed in the gut differently inhibit survival of human cell lines derived from colon adenoma (LT97) and carcinoma (HT29). J Agric Food Chem 55:2892-2900, 2007.
65. Barth SW, Fahndrich C, Bub A, y col. Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats. Carcinogenesis 26:1414-1421, 2005.
66. Huemmer W, Dietrich H, Will F, Schreier P, Richling E. Content and mean polymerization degree of procyanidins in extracts obtained from clear and cloudy apple juices. Biotechnol J 3:234-243, 2008.
67. Oszmianski J, Wolniak M, Wojdylo A, Wawer I. Comparative study of polyphenolic content and antiradical activity of cloudy and clear apple juices. J Sci Food Agric 87:573-579, 2007.
68. Ohkami H, Tazawa K, Yamashita I, y col. Effects of apple pectin on fecal bacterial enzymes in azoxymethane-induced rat colon carcinogenesis. Jpn J Cancer Res 86:523-529, 1995.
69. Poulsen M, Mortensen A, Binderup ML, Langkilde S, Markowski J, Dragsted LO. The effect of apple feeding on markers of colon carcinogenesis. Nutr Cancer 63:402-409, 2011.
70. Bruce WR. Counterpoint: from animal models to prevention of colon cáncer. Criteria for proceeding from preclinical studies and choice of models for prevention studies. Cancer Epidemiol Biomarkers Prev 12:401-404, 2003.
71. Corpet DE, Pierre F. How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon cancer chemoprevention in rats, mice and humans. Eur J Cancer 41:1911-1922, 2005.
72. Heyer J, Yang K, Lipkin M, Edelman M, Kucherlapati R. Mouse models for colorectal cáncer. Oncogene 18(38):5325-5333, 1999.
73. Pan L, Zessner H,Will F, y col. Natural cloudy apple juice and a polyphenol-enriched apple juice extract prevent intestinal adenoma formation in the App (Min/+) model for colon cancer prevention. Cancer Epidemiol Biomarkers Prev 14(11):2715s-2719s, 2005.
74. Mandir N, Englyst H, Goodlad RA. Resistant carbohydrates stimulate cell proliferation and crypt fission in wild-type mice and in the Apc mouse model of intestinal cancer, association with enhanced polyp development. Br J Nutr 100(4):711-721, 2008.
75. Fini L, Piazzi G, Daoud Y, y col. Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca applepolyphenol extract. Cancer Prev Res 4(6):907-915, 2011.

 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
ua31618
Inicio/Home

Copyright siicsalud © 1997-2024 ISSN siicsalud: 1667-9008