PREVALENCIA DE HIPOTENSION ORTOSTATICA EN ADULTOS MAYORES EN MEXICO

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La hipotensión ortostática es un problema común, pero en México se desconoce su prevalencia. Hicimos un estudio dónde cerca del 30% de la población de asilos de ancianos mostró el problema. La hipotensión ortostática se vincula con peor calidad de vida y estado cognitivo, así como con distiroidismo, ictus y alcoholismo como factores de riesgo asociados.
Autor:
Enrique Asensio-lafuente
Columnista Experto de SIIC

Institución:
Universidad del Valle de México


Artículos publicados por Enrique Asensio-lafuente
Coautores
Andrea Aguilera* Maria de los Angeles Corral C* Carla Mendoza* Pablo Nava* Ana Lilia Rendón* Liliana Villegas* Juan Manuel Fraga* Enrique Negrete* Lilia Castillo** Arturo Orea** 
Universidad del Valle de México, Querétaro, México*
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, México**
Aprobación
3 de Marzo, 2012
Primera edición
5 de Octubre, 2012
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
La hipotensión ortostática (HO) es un problema común en los adultos mayores y se asocia con el aumento de la morbimortalidad, pero su prevalencia se desconoce en México. Métodos: Se realizó un estudio transversal, prospectivo, entre sujetos internados en instituciones de asistencia a los adultos mayores. Se hizo una historia clínica y se tomaron mediciones de presión arterial en posición sedente, inmediatamente después de ponerse de pie y a los 3 minutos de la bipedestación. Resultados: Evaluamos 132 sujetos con una edad promedio de 82.3 ± 9.5 años; el 74.1% fueron mujeres. De ellos, 39 (29.3%) tuvieron HO. Estos pacientes tienen mayor prevalencia de hipotiroidismo, enfermedad de Parkinson, depresión y alcoholismo. El test de Mini Mental dio un puntaje de 15.45 ± 7.2 frente a 16.12 ± 7.9 (p = 0.6) y la escala de calidad de vida mostró un puntaje de 12.1 ± 7.3 frente a 9.15 ± 7.05 (p = 0.03), respectivamente, para los sujetos que tenían HO contra los que no. La presencia de hipertensión y alcoholismo dieron unos valores de riesgo relativo de 2.6 (intervalo de confianza del 95% [IC]: 0.9-7.6, p = 0.06) y 3.18 (IC: 0.96-10.48, p = 0.05), respectivamente, para presentar HO. Conclusiones: Se encontró que el 29.3% de esta población tiene HO. Aunque hay pocos elementos diferenciadores, llaman la atención la hipertensión, el alcoholismo y la historia de ictus. Las diferencias en el uso de medicamentos son mínimas y no explican la HO, por lo que es necesario buscar otras asociaciones, como el alcoholismo. La HO se asocia con peor calidad de vida y peor desempeño cognitivo, aunque muchas veces es asintomática.

Palabras clave
hipotensión ortostática, adultos mayores, disfunción autonómica, alcoholismo, enfermedad de Parkinson


Artículo completo

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Extensión:  +/-7.26 páginas impresas en papel A4
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Abstract
Orthostatic hypotension (OH) is a common problem among the elderly and it is associated with an increase in morbidity and mortality, but its prevalence is unknown in our country.
Methods: We conducted a cross-sectional prospective study in in-patients of several local elderly assistance institutions. We carried out a history and made blood pressure readings in sitting position, immediately after standing up and after a 3-minute stand-up.
Results: We evaluated 132 patients, mean age 82.3 ± 9.5 years, 74.1% female. Thirty-nine subjects (29.3%) have OH. They have a higher prevalence of hypothyroidism, Parkinson's disease, depression and alcoholism. Their Minimental result was 15.45 ± 7.2 vs. 16.12 ± 7.9 (p=0.6) among those without OH, and their quality of life (Minnesota scale) was 12.1 ± 7.3 vs. 9.15 ± 7.05 (p=0.03). OH patients use more ACEI, digoxin and levothyroxin. Hypertension and alcoholism history showed respectively a RR of 2.6 (IC 95% 0.9 - 7.6, p=0.06) and 3.18 (IC 95% 0.96 - 10.48, p=0.05) of developing OH.
Conclusions: OH was present among 29.3% of the studied population. One third of them had hypertension. The use of different medications did not explain OH by itself, so it is necessary to look for different associations. Among those, chronic alcoholism is particularly striking. OH is associated with worse QOL and cognitive performance, although it is asymptomatic in most cases.

Key words
orthostatic hypotension, elderly, alcoholism, Parkinson disease, autonomic dysfunction


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Cardiología, Geriatría
Relacionadas: Atención Primaria, Epidemiología, Medicina Familiar, Medicina Interna



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Enrique Asensio-Lafuente, Universidad del Valle de México, Campus Querétaro, 76230, Blvd. Villas del Mesón 1000, Edificio J, Juriquilla, Querétaro, México
Bibliografía del artículo
1. Verwoert G, Mattace-Raso F, Hofman A, Heeringa J, Sticker B, Breteler M, Witteman J. Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam Study. J Am Geriatr Soc 56(10):1816-1820, 2008.
2. Gupta V, Lipsitz L. Orthostatic hypotension in the elderly: diagnosis and treatment. Am J Med 120(10):841-847, 2007.
3. Lipsitz L, Grubb B. Syncope in the elderly. En: Grubb B, Olshansky B. Syncope, mechanisms and management. 2a ed. Armonk, VA: Blackwell-Futura; 2005. pp. 301-314.
4. Poon O, Braun U. High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. J Clin Pharm Ther 30(2):173-178, 2005.
5. Lamarre M. Syncope in older adults. Geriatrics Aging 10(4):236-240, 2007.
6. Asensio E, González JA, Ramírez LL. Guías para el manejo del síncope: diagnóstico y tratamiento. Sociedad Mexicana de Electrofisiología y Estimulación Cardíaca. Guías de práctica médica en arritmias cardíacas. 1a ed. México DF: Medtronic; 2007-2009.
7. Velázquez O, Rosas M, Lara A, Pastelín G, Attié F, Tapia R, Grupo ENSA 2000. Hipertensión arterial en México: resultados de la Encuesta Nacional de Salud (ENSA 2000). Arch Inst Cardiol 72(1):71-84, 2002.
8. Rosas M, Lara A, Pastelín G, Velázquez O, Martínez J, Méndez A et al. Reencuesta nacional de hipertensión arterial (RENAHTA): consolidación mexicana de los factores de riesgo cardiovascular. Cohorte nacional de seguimiento. Arch Inst Cardiol 75(1):96-111, 2005.
9. Liu B, Topper A, Reeves R. Falls among older people: relationship to medication use and orthostatic hypotension. J Am Geriatr Soc 43:1141-1145, 1995.
10. Tinetti M, Williams T, Mayewski R. Fall risk index for elderly patients based on number of chronic disabilities. Am J Med 80:429-434, 1986.
11. Lipsitz L, Pluchino F, Wei J. Syncope in institutionalized elderly: the impact of multiple pathological conditions and situational stress. J Chronic Dis 39:619-630, 1986.
12. van der Velde N, van den Meiracker A, Pols H, Stricker B, van der Carmenn T. Withdrawal of fall-risk-increasing drugs in older persons: effect on tilt table test outcomes. J Am Geriatr Soc 55(5):734-739, 2007.
13. Masaki K, Schatz I, Burchfiel C, Sharp D, Chiu D, Foley D et al. Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program. Circulation 98(21):2290-2295, 1998.
14. Atli T, Keven K. Orthostatic hypotension in the healthy elderly. Arch Gerontol Geriatr 43(3):313-317, 2006.
15. Luukinen H, Koski K, Laippala P, Airaksinen K. Orthostatic hypotension and the risk of myocardial infarction in the home-dwelling elderly. J Intern Med 255(4):486-493, 2004.
16. Carmona J, Amado P, Vasconcelos N, Almeida L, Santos I, Alves J et al. Does orthostatic hypotension predict the occurrence of nocturnal arterial hypotension in the elderly patient? Rev Port Cardiol 22(5):607-615, 2003.
17.- Vara L, Domínguez R, Fernández M, Josa B, Ruiz F, Zabalo A et al. Prevalencia de la hipotensión ortostática en ancianos hipertensos tratados en atención primaria. Aten Primaria 28:151-157, 2001.
18. Weiss A, Chagnac A, Beloosesky Y, Weinstein T, Grinblat J, Grossman E. Orthostatic hypotension in the elderly: are the diagnostic criteria adequate? J Hum Hypert 18:301-305, 2004.
19. Chobanian A, Bakris G, Black H, Cushman W, Green L, Izzo J et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Complete report. Hypertension 42(6):1206-1252, 2003.
20. Rosas M, Pastelín G, Martínez J, Herrera J, Attie F et al. Hipertensión arterial en México. Guías y recomendaciones para su detección y tratamiento. Arch Cardiol Mex 74:134-157, 2004.
21.- Wüllner U, Schmitz T, Anthony G, Fimmers R, Spotke A, Oertel W et al. Autonomic dysfunction in 3 414 Parkinson's disease patients enrolled in the German Network on Parkinson Disease (KNP e.V.): The effect of ageing. Eur J Neurol 14(12):1405-1408, 2007.
22. Dubow J. Autonomic dysfunction in Parkinson's disease. Dis Mon 53(5):265-274, 2007.
23. García R, López P, Tomaz C. The role played by the autonomic nervous system in the relation between depression and cardiovascular disease. Rev Neurol 44(4):225-233, 2007.
24. Cabezas-Cerrato J, Hermida R, Cabezas-Agrícola J, Ayala D. Cardiac autonomic neuropathy, estimated cardiovascular risk and circadian blood pressure pattern in diabetes mellitus. Chronobiol Int 26(5):942-957, 2009.
25. Rosengard M, Bernardi L, Fagerudd J, Mantysaari M, Af Bjorkesten C, Lindholm H et al. Early autonomic dysfunction in type 1 diabetes: a reversible disorder? Diabetología 52(6):1164-1172, 2009.
26. Jyotsna V, Sahoo A, Sreenivas V, Deepak K. Prevalence and pattern of cardiac autonomic dysfunction in newly detected type 2 diabetes mellitus. Diabetes Res Clin Pract 83(1):83-88, 2009.
27. Pop-Busui R. Cardiac autonomic neuropathy in diabetes: a clinical perspective. Diabetes Care 33(2):434-441, 2010.
28. Horie M, Ishida-Takahashi A, Ai T, Nishimoto T, Tsuura Y, Ishida H et al. Insulin secretion and its modulation by antiarrhythmic and sulfonylurea drugs. Cardiovasc Res 34(1):69-72, 1997.
29. Tinker A, Harmer S. K+ Channels in the heart: new insights and therapeutic implications. Expert Rev Clin Pharmacol 3(3):305-319, 2010.
30. Asensio E, Aguilera A, Corral MA, Mendoza K, Nava PE, Rendón AL, Villegas L, Fraga JM, Negrete E, Castillo L, Orea A. Prevalence of orthostatic hypotension in a series of elderly Mexican institutionalized patients. Cardiol J 18(3):282-288, 2011.
31. Treger I, Shafir O, Keren O, Ring H. Orthostatic hypotension and cerebral blood flow velocity in the rehabilitation of stroke patients. Int J Rehabil Res 29(4):339-342, 2006.
32. Phipps M, Schmid A, Kapoor J, Peixoto A, Milliams L, Bravata D. Orthostatic hypotension among outpatients with ischemic stroke. J Neurol Sci 314(1-2):62-65, 2012.
33. Lambert M, Thissen J, Doven C, Coche E. Orthostatic hypotension associated with hypothyroidism. Acta Clin Belg 39(1):48-50, 1984.
34. Heemstra K, Burgraaf J, van der Klaauw A, Romijn J, Smit J, Corssmit E. Short term overt hypothyroidism induces sympathovagal imbalance in thyroidectomized differentiated thyroid carcinoma patients. Clin Endocrinol 72(3):417-421, 2010.
35. Merello M, Nogues M, Leiguarda R, López C, Florin A. Abnormal sympathetic response in patients with autoinmune vitiligo and primary autoinmune hypothyroidism. J Neurol 140(2):72-74, 1993.
36. Ishizaki K, Harada T, Yamaguchi S, Mimori Y, Nakayama T, Yamamura Y et al. Relationship between impaired blood pressure control and multiple system involvement in chronic alcoholics (resumen Medline). No To Shinkei 47(2):139-45, 1995.
37. Escobar F, Espí F, Herrrero F, Benages A. Tests of autonomic cardiovascular function in chronic alcoholism. Analysis of 100 patients. Rev Clin Esp 179(8):392-396, 1986.
38. Nazliel B, Arikan Z, Irkec C, Karakilic H. SSR abnormalities in chronic alcoholics. Addict Behav 32(6):1290-1294, 2007.
39. Duncan G, Johnson R, Lambie D, Whiteside E. Evidence of vagal neuropathy in chronic alcoholics. Lancet 2(8203):1053-1057, 1980.
40. Obisesan T, Obidesan O, Martins S, Alamgir L, Bond V, Maxwell C, Frank R. High blood pressure, hypertension and high pulse pressure are associated with poorer cognitive function in persons aged 60 and older: the Third National Health and Nutrition Examination Survey. J Am Geriatr Soc 56(3):501-509, 2008.
41. Bar K, Greiner W. Pain perception is not influenced by altered autonomic function in major depression. Psychiatr Prax 34(Suppl. 3):S309-S313, 2007.
42. Staud R. Autonomic dysfunction in fibromyalgia syndrome: postural orthostatic tachycardia. Curr Rheumatol Rep 10(6):463-466, 2008.
43. Birklein F, Riedl B, Sieweke N, Weber M, Neundörfer B. Neurological findings in complex regional pain syndromes, analysis of 145 cases. Acta Neurol Scand 101(4):262-269, 2000.
44. Crofford L. Violence, stress and somatic syndromes. Trauma violence abuse 8(3):299-313, 2007.
45. Solano C, Martínez A, Becerril L, Vargas A, Figueroa J, Navarro C, Ramos-Remus C, Martínez-Lavín M. Autonomic dysfunction in fibromyalgia assessed by the Composite Autonomic Symptoms Scale (COMPASS). J Clin Rheumatol 15(4):172-176, 2009.
46. Martínez-Lavín M, Hermosillo AG. Autonomic nervous system dysfunction may explain the multisystem features of fibromyalgia. Semin Arthritis Rheum 29(4):197-199, 2000.
47. Martínez-Lavin M, Vargas A. Complex adaptive systems allostasis in fibromyalgia. Rheum Dis Clin North Am 35(2):285-298, 2009.
48. Stacy M. Medical treatment of Parkinson disease. Neurol Clin 27(3):605-631, 2009.
49. Chan D, Cordato D, O'Rourke F. Management for motor and non-motor complications in late Parkinson's disease. Geriatrics 63(5):22-27, 2008.
50. Yoritaka A, Ohizumi H, Tanaka S, Hattori N. Parkinson's disease with and without REM sleep behavior disorder: are there any clinical differences? Eur Neurol 61(3):164-170, 2009.
51. Steinman M, Rosenthal G, Landefeld C, Berthenthal D, Kaboli P. Conflicts and concordance between measures of medication prescribing quality. Med Care 45(1):95-99, 2007.
52. Lien C, Gillespie N, Struthers A, McMurdo M. Heart failure in frail elderly patients: diagnostic difficulties, co-morbidities, polypharmacy and treatment dilemmas. Eur J Heart Fail 4(1):91-98, 2002.
53. Hanlon J, Shmader K, Ruby C, Weinberger M. Suboptimal prescribing in older inpatients and outpatients. J Am Geriatr Soc 49(2):200-209, 2001.
54. Colt H, Shapiro A. Drug-induced illness as a cause for admission to a community hospital. J Am Geriatr Soc 37(4):323-326, 1989.
55. Fulton M, Riley E. Polypharmacy in the elderly: a literature review. J Am Acad Nurs Pract 17(4):123-132, 2006.
56. Asensio E, Castillo L, Oseguera J, Narváez R, Dorantes J, Orea A, Hernández P, Rebollar V. Response to treatment during medium-term follow-up in a series of patients with neurocardiogenic syncope. Arch Med Res 35(5):416-420, 2004.
57. Moya A, Sutton R, Ammirati F, Blanc JJ, Brignole M, Dahm J et al. Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J 30:2631-2671, 2009.
58. Wang J, Mullins C, Mamdani M, Rublee D, Shaya F. New diagnosis of hypertension among celecoxib and nonselective NSAID users: a population based cohort study. Ann Pharmacother 41(6):937-943, 2007.
59. Krum H, Swergold G, Curtiss S, Kaur A, Wang H, Smugar S et al. Factors associated with blood pressure changes in patients receiving diclofenac or etoricoxib: results from the MEDAL study. J Hypertens 27(4):886-893, 2009.
60. Mussi C, Ungar A, Salvioli G, Menossi C, Bartoletti A, Giada F et al. Orthostatic hypotension as cause of syncope in patients older than 65 years admitted to emergency departments for transient loss of consciousness (resumen Medline). J Gerontol A Biol Sci Med Sci 64(7):801-806, 2009.
61. Low P. Prevalence of orthostatic hypotension. Clin Auton Res 18(Suppl. 1):8-13, 2008.
62. Asensio E, Oseguera J, Loría A, Gómez M, Narváez R, Dorantes J et al. Clinical findings as predictors of positivity of head-up tilt table test in neurocardiogenic syncope. Arch Med Research 34:287-291, 2003.
63. Asensio E, Colín E, Castillo L, Oseguera J, Narváez R, Dorantes J, Galindo J, Orea A. Comportamiento diferencial de la tensión arterial de pacientes con síncope neurocardiogénico en la fase inicial de la prueba de inclinación. Arch Inst Cardiol Mex 76(1):59-62, 2006.
64. Asensio E, Castillo L, Galindo J, Narváez R, Dorantes J, Rebollar V, Orea A. Differential blood pressure behavior as an early predictor of the outcome of head-up tilt table test among patients with neurally mediated syncope. The Internet Journal of Cardiology 5(2), www.ispub.com/journal/the-internet-journal-of-cardiology/volume-5-number-2/differential-blood-pressure-behaviour-as-an-early-predictor-of-the-outcome-of-the-head-up-tilt-table-test-among-patients-with-neurally-mediated-syncope.html, 2008.
65. Asensio E, Orea A, Castillo L, Fraga JM, Colín E, Prieto J. Síncope en el anciano: hallazgos de pruebas complementarias en un centro hospitalario universitario. Arch Cardiol Mex 70(3):201-206, 2009.



 
 
 
 
 
 
 
 
 
 
 
 
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