Viviana Ritacco *

Autora invitada por SIIC

Este trabajo colaborativo entre 13 centros de referencia de Sudamérica y Europa analiza la frecuencia de cepas Beijing en 7 países de Sudamérica

LAS CEPAS BEIJING RARAMENTE CAUSAN TUBERCULOSIS EN SUDAMERICA

El análisis de los genotipos de cepas aisladas de pacientes con tuberculosis diagnosticada entre 1997 y 2003 en siete países de Sudamérica mostró la presencia de cepas Beijing en sólo 19/1 202 (1.6%) pacientes, todos nativos, excepto dos inmigrantes coreanos. La tuberculosis producida por las cepas Beijing no se asoció a farmacorresistencia.

*Viviana Ritacco
describe para SIIC los aspectos relevantes de su trabajo
MYCOBACTERIUM TUBERCULOIS STRAINS OF THE BEIJING GENOTYPE ARE RARELY OBSERVED IN TUBERCULOSIS PATIENTS IN SOUTH AMERICA
Institución principal de la investigación
*Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
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Referencias bibliográficas
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Candia N, Lopez B, Zozio T, Carrivale M, Diaz C, Russomando G, de Romero NJ, Jara JC, Barrera L, Rastogi N, Ritacco V. First insight into Mycobacterium tuberculosis genetic diversity in Paraguay. BMC Microbiol 7:75, 2007.
Chacón-Salinas R, Serafín-López J, Ramos-Payán R, Méndez-Aragón P, Hernández-Pando R, Van Soolingen D, Flores-Romo L, Estrada-Parra S, Estrada-García I. Differential pattern of cytokine expression by macrophages infected in vitro with different Mycobacterium tuberculosis genotypes. Clin Exp Immunol 140:443-449, 2005.
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Kremer K, Glynn JR, Lillebaek T, Niemann S, Kurepina NE, Kreiswirth BN, Bifani PJ, van Soolingen D. Definition of Beijing/W lineage of Mycobacterium tuberculosis on the basis of genetic markers. J Clin Microbiol 42:4040-4049, 2004.
Lazzarini LC, Huard RC, Boechat NL, Gomes HM, Oelemann MC, Kurepina N, Shashkina E, Mello FC, Gibson AL, Virginio MJ, Marsico AG, Butler WR, Kreiswirth BN, Suffys PN, Lapa E Silva JR, Ho JL. Discovery of a novel Mycobacterium tuberculosis lineage that is a major cause of tuberculosis in Rio de Janeiro, Brazil. J Clin Microbiol 45:3891-3902, 2007.
López B, Aguilar D, Orozco H, Burger M, Espitia C, Ritacco V, Barrera L, Kremer K, Hernandez-Pando R, Huygen K, van Soolingen D. A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes. Clin Exp Immunol 133:30-37, 2003.
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Olano J, López B, Reyes A, Lemos MP, Correa N, Del Portillo P, Barrera L, Robledo J, Ritacco V, Zambrano MM. Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance. Tuberculosis (Edinb) 87:502-508, 2007.
Palmero D, Ritacco V, Ambroggi M, Marcela N, Barrera L, Capone L, Dambrosi A, di Lonardo M, Isola N, Poggi S, Vescovo M, Abbate E. Multidrug-resistant tuberculosis in HIV-negative patients, Buenos Aires, Argentina. Emerg Infect Dis 9:965-969, 2003.
Palmero D, Ritacco V, Ruano S, Ambroggi M, Cusmano L, Romano M, Bucci Z, Waisman J. Multidrug-resistant tuberculosis outbreak in transvestite sex workers, Buenos Aires, Argentina. Int J Tuberc Lung Dis 9:1168-1170, 2005.
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Ritacco V, Di Lonardo M, Reniero A, Ambroggi M, Barrera L, Dambrosi A, López B, Isola N, Kantor IN. Nosocomial spread of Human Immunodeficiency Virus-related multidrug-resistant tuberculosis in Buenos Aires. J Infect Dis 176:637-642, 1997.
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Otros artículos de Viviana Ritacco

Olano J, López B, Reyes A, Lemos MP, Correa N, del Portillo P, Barrera L, Robledo J, Ritacco V, Zambrano MM. Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance. Tuberculosis (Edinb) 87:502-508, 2007.
Candia N, Lopez B, Zozio T, Carrivale M, Diaz C, Russomando G, de Romero NJ, Jara JC, Barrera L, Rastogi N, Ritacco V. First insight into Mycobacterium tuberculosis genetic diversity in Paraguay. BMC Microbiol 7:75, 2007.
Alonso V, Paul R, Barrera L, Ritacco V. Falso diagnóstico de tuberculosis por cultivo. Medicina (Buenos Aires) 67:287-94, 2007.
Kantor IN de, Ritacco V. An update on bovine tuberculosis programmes in Latin American and Caribbean countries. Vet Microbiol 112:111-118, 2006.
Palmero D, Ritacco V, Ruano S, Ambroggi M, Cusmano L, Romano M, Bucci Z, Waisman J. Multidrug-resistant tuberculosis outbreak in transvestite sex workers, Buenos Aires, Argentina. Int J Tuberc Lung Dis 9:1168-1170, 2005.
Símboli N, Takiff H, McNerney R, López B, Martin A, Palomino JC, Barrera L, Ritacco V. In-house phage amplification assay is a sound alternative for detecting rifampin-resistant tuberculosis in low-resource settings. Antimicrob Agents Chemother 49:425-427, 2005.
Palmero D, Ritacco V, Ambroggi M, Natiello M, Barrera L, Capone L, Dambrosi A, Di Lonardo M, Isola N, Poggi S, Vescovo M, Abbate E. Multidrug-resistant tuberculosis in HIV-negative patients, Buenos Aires, Argentina. Emerg Infect Dis 9:965-969, 2003.
López B, Aguilar D, Orozco H, Burger M, Espitia C, Ritacco V, Barrera L, Kremer K, Hernandez-Pando R, Huygen K, van Soolingen D. A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes. Clin Exp Immunol 133:30-37, 2003.
Ritacco V, Kremer K, Van der Laan T, Pijnenburg J, De Haas P, van Soolingen D. Use of IS901 and IS1245 in RFLP typing of Mycobacterium avium complex: relatedness among serovar reference strains, human and animal isolates. Int J Tuberc Lung Dis 2:242-251, 1998.
Ritacco V, Di Lonardo M, Reniero A, Ambroggi M, Barrera L, Dambrosi A, López B, Isola N, Kantor IN. Nosocomial spread of Human Immunodeficiency Virus-related multidrug-resistant tuberculosis in Buenos Aires. J Infect Dis 176:637-642, 1997.

Para comunicarse con Viviana Ritacco mencionar a SIIC como referencia:
vivianaritacco@gmail.com

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Acerca del trabajo completo

LAS CEPAS BEIJING RARAMENTE CAUSAN TUBERCULOSIS EN SUDAMERICA

Título original en castellano
EL GENOTIPO BEIJING DE MYCOBACTERIUM TUBERCULOSIS ES RARAMENTE OBSERVADO EN PACIENTES DE SUDAMERICA

Autores
Viviana Ritacco¹, Beatriz López², Patricia I Cafrune³, Lucilaine Ferrazoli⁴, Philip N Suffys Pn⁵, Norma Candia⁶, Lucy Vásquez⁷, Teresa Realpe⁸, Jorge Fernández⁹
1 Médica, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina, Investigador Independiente
2 Médico Veterinario, Instituto Nacional de Enfermedades Infecciosas Anlis "carlos G. Malbrán", Buenos, Profesional de Planta, Servicio de Micob
3, Centro de Biotecnologia da Universidade Federal Do Rio Grande Do Sul, Porto Aleg
4, Instituto Adolfo Lutz, Sao Paulo, Profesional, Setor de Micobactérias
5, Instituto Oswaldo Cruz, Rio de Janeiro, Head, Biochemistry And Molecular Biology
6 Bióloga, Universidad Nacional de Asunción, Asunción
7 Bióloga, Instituto Nacional de Salud, Lima
8, Corporación Para Investigaciones Biológicas, Profesional, Unidad de Bacteriología y M
9, Instituto de Salud Pública de Chile, Jefe, Genética Molecular

Acceso a la fuente original
Memorias do Instituto Oswaldo Cruz
http://memorias.ioc.fiocruz.br/

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