Se describen los resultados de la experiencia terapéutica a largo plazo con bosentano en una paciente con síndrome de Eisenmenger.

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Bibliografía del caso clínico
1. Wood P. The Eisenmenger syndrome or pulmonary hipertensión with reversed central shunt. Br Med J 1958; 2:701-9.
2. Simonneau G, Nazzareno G, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol 2004; 43:5S-12S.
3. Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004; 351:1425-36.
4. Bolger AP, Sharma R, Li W, et al. Neurohormonal activation in adults with congenital heart disease: evidence of the chronic heart failure syndrome. Circulation 2002; 106:92-9.
5. Sitbon O, Badesch DB, Channick RN, et al. Effects of the dual endothelin receptor antagonist bosentán in patients with pulmonary hipertension: a 1-year follow-up study. Chest 2003; 124:247-254.
6. Rubin LJ, Badesch DB, Barst RJ, et al. El bosentán therapy for pulmonary arterial hypertension. N Engl J Med 2002; 346:896-903.
7. Christensen D, McConnell M, Book WM, Mahle WT. Initial experience with bosentan therapy in patients with the Eisenmenger syndrome. Am J Cardiol 2004; 94:261-263.
8. Gatzoulis M, Rogers P, Li W, et al. Safety and tolerability of bosentan in adults with Eisenmenger physiology. Int J Cardiol 2005; 98(1):147-51.
9. Apostolopoulou SC, Manginas A, Cokkinos DV, Rammos S. Effect of the oral endothelina antagonist bosentán on the clinica, exercise, and haemodynamic status of patients with pulmonary arterial hypertension related to congenital heart disease. Heart 2005; 9:1447-52.
10. Galiè N, Beghetti M, Gatzoulis M, et al. Breathe-5: bosentán improves hemodynamics and exercise capacity in the first randomized placebo-controlled trial in Eisenmenger physiology. Chest 2005; 128:496S.

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