GANGLIO "CENTINELA" EN EL CARCINOMA DE LARINGE E HIPOFARINGE

(especial para SIIC © Derechos reservados)
El examen histopatológico intraoperatorio simple de los ganglios "centinela" en el carcinoma de laringe e hipofaringe permitiría a los cirujanos controlar la difusión locorregional de la neoplasia y reducir la disección cervical total.
resta9.jpg Autor:
Leonardo Resta
Columnista Experto de SIIC

Institución:
University of Bari


Artículos publicados por Leonardo Resta
Coautores
Anna Altavilla* Roberta Rossi** Vincenzo Di Nicola*** Maria Luisa Fiorella*** Andrea Marzullo**** 
Medical Doctor, Resident in Pathological Anatomy, University of Bari, Bari, Italia*
Biologist, University of Bari, Bari, Italia**
University of Bari, Bari, Italia***
Medical Doctor specialized in Pathological Anatomy, University of Bari, Bari, Italia****
Recepción del artículo
3 de Marzo, 2007
Aprobación
5 de Noviembre, 2007
Primera edición
11 de Febrero, 2008
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
La técnica del ganglio linfático centinela localiza el ganglio que drena primariamente el territorio neoplásico anatómico. Más tarde, este procedimiento ha sido aplicado a pacientes con carcinoma epidermoide (CE) de cabeza y cuello. Nuestra experiencia de veinte años con las disecciones cervicales funcionales en el cáncer de laringe e hipofaringe nos permite asegurar que existe un ganglio linfático centinela natural en estos órganos. En nuestro estudio, examinamos una serie de 170 pacientes con disecciones funcionales del cuello con metástasis mediante el uso de un procedimiento quirúrgico de acuerdo con la anatomía topográfica clásica. En los casos con metástasis ganglionares únicas, resultaban afectados en alto porcentaje los ganglios de Küttner, supraomohioideo y prelaríngeo (46%, 38% y 6%, respectivamente), lo que representa una prueba in vivo de ganglio linfático centinela. En los casos con más de tres metástasis ganglionares, los ganglios de Küttner y supraomohioideo siempre estaban afectados primariamente. En cambio, en las metástasis detectadas en otros ganglios, podría suponerse la aparición de un drenaje linfático inconstante del pedúnculo laríngeo superior o un cambio patológico del flujo linfático. Por lo tanto, el examen histopatológico intraoperatorio simple de estos ganglios permitiría a los cirujanos controlar la difusión locorregional de la neoplasia y reducir la disección cervical total. Esta acción no es predecible cuando se emplea la división de los ganglios cervicales por niveles que se utiliza actualmente.

Palabras clave
cáncer de cabeza y cuello, metástasis ganglionar, ganglio centinela


Artículo completo

(castellano)
Extensión:  +/-8.68 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

Abstract
Sentinel lymph node technique locates that node which primarily drains anatomic neoplastic territory. Lately, this procedure has been applied to patients with head and neck squamous cell carcinoma. Our twenty-year experience in functional neck dissections for larynx and hypo pharynx cancer let us to assert that there exists a natural sentinel lymph node in these organs. In our study, we examined a series of 170 patients with metastasized functional neck dissections using a surgical procedure according to classic topographic anatomy. In the cases with single nodal metastasis, Küttner, Supraomohyoid, Pre-laryngeal nodes were involved with a high percentage (46%, 38%, 6% respectively) representing an "in vivo" evidence of sentinel lymph node. In cases with more than three nodal metastases, Küttner and supraomohyoid were always primarily interested. Instead, for the metastases detected in other nodes, it might be supposed the occurrence of an unsteady lymphatic drainage of the superior laryngeal peduncle or a pathological change of the lymphatic flow. Therefore, the simple intraoperative histopathological examination of these nodes would allow surgeons to control locoregional diffusion of neoplasia and to reduce total neck dissection. This acting is not predictable using the division of cervical nodes by levels currently used.

Key words
head and neck cancer, nodal metastasis, sentinel node


Full text
(english)
para suscriptores/ assinantes

Clasificación en siicsalud
Artículos originales > Expertos del Mundo >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Oncología
Relacionadas: Anatomía Patológica, Diagnóstico por Laboratorio, Medicina Interna



Comprar este artículo
Extensión: 8.68 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra



Enviar correspondencia a:
Leonardo Resta, University of Bari Department of Pathological Anatomy, Policlinico, 70124, Piazza Giulio Cesare, N°11, Bari, Italia
Bibliografía del artículo
1. Morton D, Wen DR, Wong J. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 127:392-399, 1992.
2. Brobeil A, Cruse CW, Messina JL. Cost analysis of sentinel lymph node biopsy as an alternative to elective lymph node dissection in patients with malignant melanoma. Surg Oncol Clin North Am 8:435-445, 1999.
3. Pinel J, Cachin Y, Lacoureye H et al. Cancer du larynx (indications thèrapeutiques, resultants). Ed. Arnette, Paris, pp. 34-38, 1980.
4. Rouvière H. Lymphatiques de la tète et du cou. In: Anatomie humaine descriptive et topographique. Tome I. Masson, Paris, pp. 212, 1924.
5. Micheau C, Luboinski B, Sancho H, Cachin Y. Modes of invasion of cancer of the larynx: a statistical, histological and radio-clinical anaysis of 120 cases. Cancer 38:346-360, 1976.
6. Resta L. Modalità di diffusione del carcinoma laringeo: I diffusione locale. Folia Oncologica 6:164-177, 1983.
7. Resta L. Modalità di diffusione del carcinoma laringeo: II diffusione linfatica. Folia Oncologica 6:190-198, 1983.
8. Resta L, Fiorella R. Studio morfometrico dei linfonodi latero-cervicali nel carcinoma laringeo. Pathologica 75:65-80, 1983.
9. Ferlito A, Rinaldo A. Selective lateral neck dissection for laryngeal cancer with limited metastatic disease: is it indicated? J Laryngol Otol 112:1031- 1033, 1998.
10. Subcommitee for Neck Dissection: Terminology and classification division of lymph nodes by levels. In: Robbins KT (ed) Pocket guide to neck dissection and TNM staging of head and neck cancer. Alexandria, VA: American Academy of Otolaryngology and Head and Neck Surgery Foundation, Inc. p.12, 1991.
11. Lawrence WD. ADASP recommendations for processing and reporting of lymph node specimens submitted for evaluation of metastatic disease. Virchows Arch 439:601-603, 2001.
12. Batsakis J. The lymph node yield in neck dissections: a mean of 35 nodes is excellent, but variance is much too wide. Why? Advances in Anatomic Pathology 9:73, 2002.
13. Buckley G J, MacLennan K. Cervical node metastases in laryngeal and hypo-pharyngeal cancer: a prospective analysis of prevalence and distribution. Head & Neck 22:380-385, 1999.
14. Chodynicki S, Lazarczyk B, Woinska-Rojecka T, Poludniewska B. Modified neck dissection-efficiency of surgical treatment and clinical observations. Med Sci Monit 8(2):CR 93-95, 2002.
15. Beck Cl, Mann W. The inner laryngeal lymphatics. A lymphangioscopical and electron microscopical study. Acta Otolaryngol 89:265-270, 1980.
16. Verge P, Venneuville G, Verge-Garret J, Theveron D,Fain J, Chavaz J. Les Lymphatiques du larynx, etude anatomique. Cahiers ORL 16:329-339, 1981.
17. Canizo A A. The Lymphatics network of the larynx. Rev Laryngol 103:43-48, 1982.
18. Welsh LW, Welsh JJ, Rizzo TA Jr. Laryngeal spaces and lymphatics: current anatomic concepts. Ann Otol Rhinol Laryngol Suppl 92(105):19-31, 1983.
19. Fisch UP, Sigel ME. Ann Otol 73:869-82, 1964.
20. Civantos F J, Gomez C, Duque C, Pedroso F, Goodwin WJ, Weed D et al Sentinel node biopsy in oral cavity cancer: correlation with P scan and immunochemistry. Head & Neck 25(1):1-9, 2003.
21. Linderbergh R. Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 29:1446-1449, 1972.
22. Agazzi C. Consideration sur les problème des adenopathies cervicales dans le cancer du larynx et du pharynx et sur la choix des techniques d'èvidement ganglionnaire. Rev Med 8:595-604, 1968.
23. Wong JR, Rinaldo A, Ferlito A, Shah. Ocult cervical metastases in head and neck cancer and its impact on therapy. 122:107-114, 2002.
24. Chone C, Crespo A, Rezende A, Carvalho D, Altemani A. Neck lymph node metastases to the posterior triangle apex: evaluation of clinical and histopathological risk factors. Head & Neck 22:564-571, 2000.
25. Resta L, Micheau C. Prognostic value of the pre-laryngeal node in laryngeal and hypopharyngeal carcinoma. Tumori 71:361-365, 1985.
26. Buckley G J, Feber T. Surgical treatment of cervical node metastases from squamous carcinoma of the upper aero-digestive tract: evaluation of the evidence for modifications of neck dissection. Head & Neck 23:907-915, 2001.
27. Pitman KT, Johnson JT, Brown ML, Myers EN. Sentinel lymph node biopsy in head and neck squamous cell carcinoma. Laryngoscope 112:2101-2113, 2002.
28. Lassaletta L, García Pallares M, Morera E, Salinas S, Bernáldez R, Patron J et al. Functional neck dissection for the clinically negative neck: effectiveness and controversies. Ann Otol Rhinol Laryngol 111(2):169-173, 2002.
29. Ambrosh P, Kron M, Fischer G, Brinck U. Micro metastases in carcinoma of the upper aero-digestive tract: detection, risk of metastasizing, and prognostic value of depth of invasion. Head & Neck 17:473-479, 1995.
30. Alex JC. Sentinel lymph node radiolocalization in head and neck squamous cell carcinoma. The Laryngoscope 110:198-203, 2000.
31. Pastore A , Turetta GD, Tarabini A, Turetta D, Feggi L, Pelucchi S. Sentinel lymph node analysis in squamous carcinoma of the oral cavity and oropharynx. Tumori 88(3) s58-60, 2002.
32. Civantos FJ, Gómez C, Duque C, Pedroso F, Goodwin WJ, Weed D, et al. Sentinel node biopsy in oral cavity cancer: correlation with P scan and immunochemistry. Head & Neck 25(1):1-9, 2003.
33. Dunne AA, Jungclas H, Werner JA. Intraoperative sentinel node biopsy in patients with squamous cell carcinomas of the head and neck experiences using a well-type Na I detector for gamma ray spectropy. Otolaryngol Pol 55(2):127-34, 2001.
34. Werner JA, Dunne AA, Ramaswamy A, Dalchow C, Behr T, Moll R, Folz BJ, Davis RK. The sentinel node concept in head and neck cancer: solution for the controversies in the NO neck? Head & Neck 26(7):603-11, 2004.
35. Ross GL, Soutar DS, MacDonald D, Shoaib T,Camilleri I, Roberton AG et al. Sentinel nodebiopsy in head and neck cancer: preliminary results of a multicenter trial. Ann Surg Oncol 11(7):690-6, 2004.
36. Mamelle G. Selective neck dissection and sentinel node biopsy in head and neck squamous cell carcinomas. Recent Results Cancer Res 157:193-200, 2000.
37. Nieuwenhuis EJ, Snow GB. Histopathological validation of the sentinel node concept in oral and oropharyngeal squamous cell carcinoma, Head & Neck 27(2):150- 8, 2005.
38. Jose J, Coatesworth A, Mac Lennan K. Cervical metastases in upper aerodigestive tract squamous cell carcinoma: histopathological analysis and reporting. Head & Neck 25:194-197, 2003.

 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
ua31618
Inicio/Home

Copyright siicsalud © 1997-2024 ISSN siicsalud: 1667-9008