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REVISAN LOS MECANISMOS DE RESISTENCIA A LA TIGECICLINA

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La tigeciclina es un antibiótico promisorio, a pesar de que algunas especies como Pseudomonas aeruginosa y Proteus spp. muestran menor sensibilidad y de que se notificaron casos de resistencia entre numerosos microorganismos. La resistencia cruzada con las tetraciclinas es muy limitada. Sin embargo, las bombas de expulsión activa de múltiples fármacos pueden comprometer la utilización de la tigeciclina en el futuro.
fluit9.jpg Autor:
Ad c. Fluit
Columnista Experto de SIIC

Institución:
Eijkman-Winkler Institute, University Medical Center Utrecht

Artículos publicados por Ad c. Fluit
Recepción del artículo
20 de Junio, 2006 		Aprobación
27 de Junio, 2006
Primera edición
5 de Octubre, 2006 		Segunda edición, ampliada y corregida
7 de Junio, 2021

REVISAN LOS MECANISMOS DE RESISTENCIA A LA TIGECICLINA

Resumen
La tigeciclina es un antibiótico nuevo, obtenido a partir de la tetraciclina. La resistencia a este agente se mantiene baja, aunque ya se notificó la existencia de cepas con menor sensibilidad y con resistencia. La resistencia a la tigeciclina no se debe al flujo activo mediado por Tet ni a la protección ribosomal observados con las tetraciclinas. Sin embargo, las bombas de expulsión activa de múltiples fármacos parecen estar implicadas en este fenómeno y pueden comprometer la utilización futura de la tigeciclina.

Palabras clave
Tigeciclina, resistencia, tetraciclina, mecanismo de resistencia


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RESISTANCE TO TIGECYCLINE

Abstract
Tigecycline is a novel antibiotic derived from tetracycline. Resistance to tigecycline is still low, although isolates with reduced susceptibility and resistance have been reported. Resistance to tigecycline is not caused by Tet-mediated efflux or ribosomal protection seen for tetracycline. However, multidrug efflux pumps appear to be involved in resistance to tigecycline and may threaten its use in the future.

Key words
Tigecycline, tetracycline, resistance, mechanism of resistance


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Especialidades
Principal: Infectología
Relacionadas: Bioquímica, Farmacología, Genética Humana, Medicina Farmacéutica, Medicina Interna



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Ad C. Fluit, Eijkman-Winkler Institute, University Medical Center Utrecht, 3508 GA, PO Box 85500, Utrecht, Países Bajos
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