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GRUPOS SANGUINEOS ABO, LEWIS, STATUS SECRETOR E INFECÇAO PELO HELICOBACTER PYLORI

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Os grupos sangüíneos ABO, Lewis e o status secretor têm sido avaliados, isoladamente ou em conjunto, como marcadores de suscetibilidade à infecção pelo Helicobacter pylori e algumas doenças a ele relacionadas
demattos9.jpg Autor:
De mattos, luiz carlos
Columnista Experto de SIIC

Institución:
Biotechnology Research Centre Auckland University of Technology Scott Laboratory Building Auckland, New Zealand

Artículos publicados por De mattos, luiz carlos
Recepción del artículo
3 de Mayo, 2004 		Aprobación
15 de Septiembre, 2004
Primera edición
4 de Noviembre, 2004 		Segunda edición, ampliada y corregida
7 de Junio, 2021

GRUPOS SANGUINEOS ABO, LEWIS, STATUS SECRETOR E INFECÇAO PELO HELICOBACTER PYLORI

Resumen
Os grupos sangüíneos ABO, Lewis e o status secretor têm sido avaliados, isoladamente ou em conjunto, como marcadores de suscetibilidade à infecção pelo Helicobacter pylori e algumas doenças a ele relacionadas. Os resultados das análises envolvendo indivíduos normais e pacientes com diferentes doenças gastroduodenais, bem como os dados experimentais, são discordantes. Se por um lado há demonstrações que reforçam a importância dos antígenos ABH-Lewis na aderência do H. pylori à mucosa gástrica dos indivíduos do grupo O, por outro, nem todos os estudos epidemiológicos suportam estas proposições e portanto, persistem as divergências entre os dados clínicos e os laboratoriais. Como os antígenos ABH-Lewis do trato gastrointestinal apresentam um perfil polimórfico que pode ser diferenciado daquele observado nos eritrócitos, parece oportuno que outros aspectos relacionados à expressão destes glicoconjugados devem ser avaliados para dar maior suporte à interpretação dos resultados observados na presença ou ausência de infecção e nas doenças relacionadas ao H. pylori. Isso poderá contribuir para a compreensão da importância biológica e evolutiva desses marcadores genéticos nas doenças infecciosas.

Palabras clave
Grupos sangüíneos; sistema ABO; sistema Lewis


Artículo completo
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THE ABO, LEWIS BLOOD GROUPS, SECRETOR STATUS, AND HELICOBACTER PYLORI INFECTION

Abstract
 The ABO and Lewis blood groups and the secretor status have been available, either in isolation or jointly, as markers for Helicobacter pylori infection susceptibility or infection by some related diseases. Results from analysis involving apparently normal individuals and patients suffering from varying gastroduodenal diseases, as well as experimental data, are contradictory. If on one hand there are demonstrations that reinforce the importance of ABH-Lewis antigens in the adherence of H. pylori to the gastric mucous membrane of O blood group individuals, on the other hand, not all epidemiological studies support these premises and thus, divergences between clinical and laboratory data remain. As the ABH-Lewis antigens of the gastroduodenal tract present a polymorphic profile which can be discriminated from those observed in red blood cells, it seems sensible that other aspects related to the expression of these glycoconjugates should be assessed. This will give greater support to the interpretation of the results in the presence or absence of infection and in diseases associated to H. pylori and may contribute to the understanding of the biological and evolutionary importance of these genetic markers in infectious diseases.

Key words
Blood groups, ABO, Lewis, secretor phenotypes, secretor status, Helicobacter pylori

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Genética Humana, Inmunología
Relacionadas: Epidemiología, Gastroenterología, Hematología, Infectología



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Enviar correspondencia a:
de Mattos, Luiz Carlos
Patrocinio y reconocimiento:
Agradecimentos: O autor agradece o apoio recebido da Faculdade de Medicina de São José do Rio Preto (FAMERP) e da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - BEX 1542-03-6).
Bibliografía del artículo
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