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CITRATO DE SILDENAFIL EN MODELOS EXPERIMENTALES DE SINDROMES CORONARIOS AGUDOS

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En modelos experimentales de angina inestable y de síndrome coronario agudo, el sildenafil no exacerba la isquemia.
przyklenk.jpg Autor:
Karin Przyklenk
Columnista Experto de SIIC
Artículos publicados por Karin Przyklenk
Coautor
Rakesh Kukreja* 
PhD, Medical Collage of Virginia, Virginia Commonwealth University, Richmond, EE.UU.*
Recepción del artículo
7 de Abril, 2003 		Primera edición
11 de Julio, 2003 		Segunda edición, ampliada y corregida
7 de Junio, 2021

CITRATO DE SILDENAFIL EN MODELOS EXPERIMENTALES DE SINDROMES CORONARIOS AGUDOS

Resumen
La investigación reciente prestó máxima atención a la seguridad y a las consecuencias cardiovasculares del citrato de sildenafil en el contexto de la enfermedad coronaria. En esta revisión, presentamos las evaluaciones realizadas en nuestros estudios de la acción del sildenafil en modelos experimentales de síndromes coronarios agudos. Las observaciones demuestran que el fármaco no exacerba la isquemia en perros con estenosis coronaria -modelo que simula la situación clínica de la "hibernación a corto plazo"- o con angina inestable. Más aún, brindamos evidencia del efecto protector del sildenafil en conejos y modelos murinos de infarto agudo de miocardio.

Palabras clave
Isquemia de miocardio, infarto de miocardio, flujo coronario, estenosis coronaria


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SILDENAFIL CITRATE IN EXPERIMENTAL MODELS OF ACUTE CORONARY SYNDROMES

Abstract
Considerable recent interest has focused on the safety and cardiovascular consequences of sildenafil citrate in the setting of coronary artery disease. Our aim in this review is to summarize our experimental studies evaluating the effects of sildenafil in experimental models of acute ischemic syndromes. We report that sildenafil does not exacerbate ischemia in canine models of coronary artery stenosis mimicking clinical instances of \'short-term hibernation\' and unstable angina. Moreover, we provide evidence of sildenafil-induced cardioprotection in rabbit and murine models of acute myocardial infarction.

Key words
Isquemia de miocardio, infarto de miocardio, flujo coronario, estenosis coronaria


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Especialidades
Principal: Farmacología
Relacionadas: Cardiología, Medicina Interna, Urología



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Bibliografía del artículo
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Título español
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