HEMORRAGIAS UTERINAS ANORMALES NO ORGANICAS

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Descripción de las principales causas de sangrado uterino anormal y resumen de las nuevas directrices más relevantes para el diagnóstico y el tratamiento del sangrado uterino anormal no orgánico.
castelobranco9_81716.jpg Autor:
Camil Castelo-branco
Columnista Experto de SIIC

Institución:
Universidad de Barcelona


Artículos publicados por Camil Castelo-branco
Coautor
Jose Antonio Lejarcegui Fort* 
Medico, Universidad de Barcelona*
Recepción del artículo
4 de Enero, 2016
Aprobación
12 de Mayo, 2016
Primera edición
18 de Agosto, 2016
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
La hemorragia uterina anormal (HUA) es un trastorno ginecológico muy común, que puede deberse a varias causas. La Federación Internacional de Ginecología y Obstetricia (FIGO) publicó unas directrices en 2011 para establecer una nomenclatura que fuera universalmente aceptada y un sistema de clasificación. El sistema de clasificación de la FIGO (PALM-COEIN) se publicó para intentar estandarizar la terminología que se empleaba en el diagnóstico y en la investigación de las causas de sangrado uterino anormal. Según la nueva clasificación de la FIGO, en ausencia de una patología estructural, debe evitarse el empleo de la antes denominada "hemorragia uterina disfuncional" y los médicos deben indicar si la HUA está ocasionada por trastornos de la coagulación (HUA-C), trastorno de la ovulación (HUA-O), yatrogenia (HUA-I), disfunción primaria del endometrio (AUB-E) o causas no clasificables (HAU-N). Este sistema se basa en el patrón y la etiología de la hemorragia y ha sido adoptado por otras organizaciones. Además, el Colegio Americano de Obstetricia y Ginecología (ACOG) han actualizado recientemente las recomendaciones sobre la evaluación de sangrado uterino anormal, así como las indicaciones para la práctica de biopsias endometriales. En resumen, la HUA es una queja común que puede variar de leve a potencialmente mortal si no se reconoce y trata a tiempo. En esta revisión se describen las principales causas de sangrado uterino anormal y resumimos las nuevas directrices más relevantes para el diagnóstico y el tratamiento del sangrado uterino anormal no orgánico que comprende HUA-C, HUA-O, HUA-E, HUA-I y HUA-N.

Palabras clave
hemorragia uterina anormal, coagulopatías, disfunción ovulatoria, endometrio, yatrogenia, histeroscopia, histerectomia


Artículo completo

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Abstract
Abnormal uterine bleeding (AUB) is a very common gynecological condition, which may have several causes. A new classification system was recently proposed to standardize the terminology used to describe Abnormal Uterine Bleeding. The International Federation of Gynecology and Obstetrics (FIGO) published guidelines in 2011 to develop universally accepted nomenclature and a classification system. The FIGO classification system (PALM-COEIN) was published to standardize the terminology used in the diagnosis and in investigations into the causes of abnormal uterine bleeding. According to the new FIGO classification, in the absence of structural etiology, the former term "dysfunctional uterine bleeding" should be avoided and clinicians should specify whether AUB is caused by coagulation disorders (AUB-C), ovulation disorder (AUB-O), or endometrial primary dysfunction (AUB-E). This system is based on the pattern and etiology of bleeding and has been adopted by other organizations. Additionally, the American College of Obstetrics and Gynecology (ACOG) has recently updated the recommendations on evaluation of abnormal uterine bleeding and the indications for endometrial biopsies. In short, AUB is a common complaint that can vary from mild to life-threatening if not recognized and treated promptly. In this review, we describe the main causes of abnormal uterine bleeding and summarize the most relevant new guidelines for the diagnosis and management of non-organic abnormal uterine bleeding that comprises AUB-C, AUB-O, AUB-E, AUB-I and AUB-N due to other non-classifiable causes.

Key words
abnormal uterine bleeding, coagulation diseases, ovulatory dysfunction, endometrium, hysteroscopy, hysterectomy, iatrogen


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Medicina Reproductiva, Obstetricia y Ginecología
Relacionadas: Anatomía Patológica, Atención Primaria, Cirugía, Diagnóstico por Imágenes, Emergentología, Hematología, Medicina Familiar, Medicina Interna



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Camil Castelo-Branco, Universidad de Barcelona, 08036, Villarroel 170, Barcelona, España
Bibliografía del artículo
1. Lee CA, Kadir RA, Kouides PA, Edlund M. Inherited bleeding disorders in women. Edited by Christine A Lee, Rezar A Kadir, Kouides PA. Wiley-Blackwell, Chapter 2: pp. 12-33, 2002.
2. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J MED 359(9):938-49, 2008.
3. Lockwood CJ. Mechanisms of normal and anormal endometrial bleeding. Menopause 18(4):408-11, 2011.
4. Hoffbrand AV, Moss PAH, Petit JE. Essential haematology 6th 2006, Blackwell Publishing Ltd.
5. Koh SC, Wong PC, Yuen R, Chua SE, Ng BL, Ratmam SS. Concentration of plasminogen activators and inhibitor in the human endometrium at different phases of menstrual cycle. J ReprodFertil 96(2):407-13, 1992.
6. Berbic M, Ng CHM, Fraser IS. Inflammation and endometrial bleeding. Climateric 17(Suppl 2):47-53, 2014.
7. Malik S, Day K, Perrault I, Charsach-Jones S, Smith SK. Reduced levels of VEGF-A and MMP2 and MMP9 activity and increased TNF-alpha in menstrual endometrium and effluent in women with menorrhagia. Hum Reprod 21(8):158-66, 2006.
8. Munro MG, Critchley HOD, Fraser IS. The FIGO classification of causes of abnormal uterine bleeding in the reproductive years. Fertility and Sterility 95(7):2204-08, 2011.
9. James AH, Manco-Johnson MJ, Yawan BP, Dietrich JE, Nichols WL. Von Willebrand disease key points from the 2008 National Heart, Lung, and Blood Institute guidelines. Obstet Gynecol 114:674-8, 2009.
10 James AH. Von Willebrand disease. Obstet Gynecol Surv 61:136-45, 2006.
11. James AH, Kouides PA, Abdul-Kadir R, Dietrich JE, Edlund M, Federici et al. Evaluation and management of acute menorrhagia in women with and without underlying bleeding disorders consensus from as international expert panel. Eur J Obstet Gynecol Reprod Biol 158:124-34, 2011.
12. Kouides PA, Conard J, Peyvandi F, Lukes A, Kadir R. Hemostasis and menstruation: appropriate investigation for underlying disorders of hemostasis in women with excessive menstrual bleeding. Fert Steril 84:1345-51, 2005.
13. Favoloro EJ, Bonar R, Sioufi J, Hertzberg M, Street AA, Lloy J, Marsden K. Current practice in the southern hemisphere. Am J Clin Pathol 119:882-93, 2003.
14. National Heart, Lung, and Blood Institute. The diagnosis, evaluation, and management of von Willebrand disease. NIH Publication No, 08-5832. Bethesda (MD); NHLBI, 2007/2013.
15. Kadir RA, Lukes AS, Kouides PA, Fernández H, Gouddemand J. Management of excessive menstrual bleeding in women with hemostatic disorders. Fert Steril 84:1352-9, 2005.
16. Fraser IS, Porte RJ, Kouides PA, Lukes AS. A benefit-risk review of systemic haemostatic agents part 2; in excessive or heavy menstrual bleeding. Drug Saf 31:275-82, 2008.
17. Lukes AS, Moore KA, Muse KN, Gerten JK, Hecht BR, Edlund M, et al. Tranexamic acid treatment for heavy menstrual bleeding: a randomized controlled trial. Obstet Gynecol 116:865-75, 2010.
18. Kingman CE, Kadir RA, Lee CA, Economides DL. The use of levonorgestrel-releasing intrauterine system for treatment of menorrhagia in women with inherited bleeding disorders. BJOG 111:1425-8, 2004.
19. Chi C, Pollard D, Tuddenham EG, Kadir RA. Menorrhagia in adolescents with inherited bleeding disorders. J Pediatr Adolesc Gynecol 23:215-22, 2010.
20. Ahuja SP, Herrtweck SP. Overview of bleedng disorders in adolescent females with menorrhagia. J Pediatr Adolesc Gynecol 23(suppl):S15-21, 2010.
21. Kouides PA, Byams VR, Philipp CS, Stein SF, Heit JA, Lukes AS, et al. Multisite managment study of menorrhagia with abnormal laboratory haemostasis a prospective crossover study of intranasal desmopressin and oral tranexamic acid. Br J Haematol 145:212-20, 2009.
22. Morrell MJ, Hayes FJ, Sluss PM et al. Hyperandrogenism, ovulatory dysfunction, and polycistic ovary síndrome with valproate versus lamotrigine. Ann Neurol 64(2):200-11, 2008.
23. Madhusoodanan S, Parida S, Jimenez C. Hyperprolactinemia associated with psychotropics-a review. Hum Psychopharmacol 25(4):281-297, 2010.
24. Soliman PT, Oh JC, Schmeler KM, et al. Risk factors for young premenopausal women with endometrial cancer. Obstet Gynecol 105(3):575-580, 2005.
25. Stovall DW, Anderson RJ, DeLeon FD. Endometrial adenocarcinoma in teenagers.Adolesc Pediatr Gynecol 2:157-159, 1989.
26. Ash SJ, Farreil SA, Flowerdew G. Endometrial biopsy in DUB. J Reprod Med 41(12):892-6, 1996.
27. Lacey JV Jr, Chia VM. Endometrial hyperplasya and the risk of progresión to carcinoma. Maturitas 63(1):39-44, 2009.
28. Salvi A, Mital P, Hooja N, Batar A, Soni P, Beniwal R. Spectrum of endometrial histopathology in women presenting with abnormal uterine bleeding. Sch J App Med Sci 3(1A):1-4, 2015.
29. Zervou S, Klentzeris LD, Old RW. Nitric oxide synthase expression and steroid regulation in the uterus of women with menorragia.Mol Hum Reprod 5(11):1048-54, 1999.
30. Lockwood CJ, Krikun G, Runic R, Schwartz LB, Mesia AF, Schatz F. Progestin-epidermal growth factor regulation of tissue factor expression during decidualization of human endometrial stromal cells. J Clin Endocrinol Metab 85(1):297-301, 2000.
31. Edlund M, Andersson E, Fried G. Progesterone withdrawal causes en endothelinreléase from cultered human uterine microvascularendotelial cells. Human Reprod 19(6):1272-80, 2000.
32. Krikun G, Lockwood CJ, Paidas MJ. Tissue factor and the endometrium: from physiology to pathology. Thromb Res 124(4):393-6, 2009.
33. Edlund M, Blomback M, He S. On the correlation between local fibrinolytic activity in menstrual fluid and total blood loss during menstruation and effects of desmopressin. Blood Coagul Fibrinolysis 14(6):593-8, 2003.
34. Gleeson N, Devitt M, Sheppard BL, Bonnar J. Endometrial fibrinolytic enzymes in women with normal menstruation and dysfunctional uterine bleeding. Br J Obstet Gynaecol 100(8):768-71, 1993.
35. Zhu PD, Luo HZ, Shi WL, Wang JD, Cheng J, Xu RH, Gu Z. Observation of the activity of factor VIII in the endometrium of women pre- and post-insertion of three types of IUDs. Contraception 44(4):367-84, 1191.
36. Rodriguez A, Escartin I, Riazuelo G, Zaragozano R. Malformación arteriovenosa uterina como rara causa de sangrado genital. Radiología 44(02):81-3, 2002.
37. Oride A, Kanasaki H, Miyazaki K. Disappearance of uterine arteriovenous malformation following long-term administration of oral norgestrel/ethinyl estradiol. J Obstet Gynaecol Res 40(6):1807-10, 2014.
38. Mendoza H, Ortiz C. Hipertrofiadifusa del miometrio. Causa de sangrado uterino anormal. Estudio clínico-patológico de cuatro casos y análisis de la literatura. Ginecol Obstet Méx 67(8):370-3, 1999.
39. Kannar V, Lingaiah HKM, Sunita V. Evaluation of endometrium for chronic endometritis by using Syndecan-1 in abnormal uterine bleeding. Journal of Laboratory Physicians 4(2):69-73, 2012.
40. Speroff L, Fritz MA. Clinical Gynecologic Endocrinology and Infertelity 7 th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, pp. 402- 811, 2005.
41. Opolskiene G, Sladkevicus P, Valentin L. Ultrasound assessment of endometrial morphology and vascularity to predict endometrial malignancy in women with postmenopausal bleeding and sonographic endometrial thickness > 4.5 mm. Ultrasound ObstetGynecol 30(3):332-40, 2007.
42. Timmerman D, Verguts J, Konstantinovic ML, Moerman P, Van Schoubroeck D, Deprest J, Van Huffel S. The pedicle artery sign base don sonography with Doppler imaging can replace second-stage tests in women with abnormal vaginal bleeding. Ultrasound Obstet Gynecol 22(2):166-71, 2003.
43. Lieng M, Istre O, Qvigstad E. Treatment of endometrial polyps: a systematic review. Acta Obstet Gynecol Scand 89(8): 992-1002, 2010.
44. Davis PC, O´Neil MJ, Yoder IC, Lee SI, Mueller PR. Sonohysterographic findings of endometrial and subendometrial conditions. Radio Graphics 22:803-16, 2002.
45. Lil V. Imaging techniques in the management of abnormal vaginal bleeding in non-pregnant women before and after menopause. Best Practice & Research Clinical Obstetrics and Gynaecology 28:637-54, 2014.
46. Lasmar RB, Dias R, Barrozo PRM, Oliveira MP, Coutinho FES, Da Rosa DB. Prevalence of hysterscopic findings and histologic diagnoses in patients with abnormal uterine bleeding. Fertility and Sterility 89(6):1803-1807, 2008.
47. Loiacono RMR, Trojano G, Gaudio N, Kardhashi A, Deliso MA, Falco G, Sforza R, Laera AF, Galise I, Trojano V. Hysteroscopy as a valid tool for endometrial pathology in patients with postmenopausal bleeding or asymptomatic patients with a thickened endometrium: Hysteroscopic and histological results. Gynecol Obstet Invest 79(3):210-6, 2015.
48. Damie RP, Dravid NV, Suryawanski KH, Grade AS, Bagde PS. Clinicopathological spectrum of endometrial changes in peri-menopausal and post-menopausal abnormal bleeding: a 2 years study. J Clin Diagn Res 7(12):2774-6, 2013.
49. Rauf R, Shahenn A, Sadia S, Wagen F, Zafar S, Sultana S, Wassen J. Outpatient endometrial biopsy with Pipellevs diagnostic dilatation and curettage. J Ayub Med Cell Abbottabad 26(2):145-8, 2014.
50. Phaliwong P, Taneepanichskul S. The effect of mefenamicacido n controlling irregular uterine bleeding second to Implanon use. J Med Assoc Thai 87(Suppl 3):S64-8, 2004.
51. Reid PC, Virtanen-Kari S. Randomized comparative trial of the levonorgestrel intrauterine system and mefenamic acid for the treatment of idiopatic menorrhagia: a multiple analysis using total menstrual fluid loss, menstrual blood loss and pictorial blood loss assessment charts. BJOG 112:121-5, 2005.
52. Dockeray CJ, Sheppard BL, Daly L, Bonnar J. The fibrinolytic enzyme system in normal menstruation and excessive uterine bleeding and the effect of tranexamic acid. Eur J Obstet Gynecol Reprod Biol 24(4):309-18, 1987.
53 Bonnar J, Sheppard BL. Treatment of menorrhagia during menstruaation: raandomized controlled trial of ethamsylate, mefenamic acid, and tranexamic acid. BMJ 313(7057):579-82, 1996.
54. Freeman EW, Lukes A, VanDrie D, Mabey RG, Gersten J, Adomako TL. A dose-response study of a novel, oral tranexamic formulation for heavy menstrual bleeding. Am J Obstet Gynecol 205(4):319e1-7, 2011.
55. Jensen JT, Parke S, Mellinger U, Machlitt A, Fraser IS. Bleeding with estradiol valerate and dienogest: A randomized controlled trial. Obstet Gynecol 117:777-87, 2011.
56. DeVore GR, Owens O, Kase N. Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding-a doublé-blind randomized control study. Obstet Gynecol 59(3):285-91, 1981.
57. Amsterdam A, Jakubowski A, Castro-Malaspina H, Baxi E, Kauff N, Krychman M, Stier E, Castiel M. Treatment of menorrhagia in women undergoing hematopoietic stem cell transplantation. Bone Marrow Transplantation 34:363-6, 2004.
58. Dhananjay BS, Sunil Kumar Nanda. The role of Sevista in the management of dysfunctionaal uterine bleeding. Journal of Clinical and Diagnostic Research 7(1):132-134, 2013.
59. Dhamangaonkar PC, Anuradha K, Saxena A. Levonorgestrel intrauterine system (Mirena): An emerging tool for conservative treatment of abnormal uterine bleeding. J Midlife Health 6(1):26-30, 2015.
60. Qiu J, Cheng J, Wang Q and Hua J. Levonorgestrel-releasing intrauterine system versus medical therapy for menorrhagia: a systematic review and meta-analysis. Med Sci Monit 20:1700-13, 2014.
61. Bowkley CW, Dubel GJ, Haas RA, Soares GM, Ahn SH. Uterine artery embolization for control of life-threatening hemorrhage at menarche: brief report. J Vas Interv Radiol 18(1 Pt 1):127-31, 2007.
62. Rouhani G, Menon S, Burgis J, et al. An unusual method to manage a rare blood discrasia. J Pediatradolesc Gynecol 20(2): S123-4, 2003.
63. El-Nashar SA, Hopkins MR, Feitoza SS, Pruthi RK, Barnes SA, Gebhart JB, Cliby WA, Famuyide AO. Global endometrial ablation for menorrhagia in women with bleeding disorders. Obstet Gynecol 109(6):1381-7, 2007.
64. Connor M. New technologies and innovations in hysteroscopy. Best Practice & Research Clinical Obstetrics and Gynaecology 29(7):951-65, 2015.

 
 
 
 
 
 
 
 
 
 
 
 
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