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AUMENTO DE MORTALIDADE COM O USO DO FENOTEROL EM ASMA: EVIDENCIA HISTORICA SUFICIENTE PARA DISCUTIR SUAS INDICAÇOES NO BRASIL?

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Com as evidências vigentes, a utilização irrestrita de fenoterol em asma deveria ser discutida por especialistas, sociedades médicas e órgãos governamentais no Brasil.
Autor:
Andrea m Rodrigues
Columnista Experto de SIIC

Institución:
Pontificia Universidade Católica do Rio Grande do Sul

Artículos publicados por Andrea m Rodrigues
Coautor
Emerson r da Silva* 
Universidade de Caxias do Sul, Caxias do Sul, Brasil*
Recepción del artículo
29 de Abril, 2013 		Aprobación
25 de Junio, 2013
Primera edición
1 de Abril, 2013 		Segunda edición, ampliada y corregida
7 de Junio, 2021

AUMENTO DE MORTALIDADE COM O USO DO FENOTEROL EM ASMA: EVIDENCIA HISTORICA SUFICIENTE PARA DISCUTIR SUAS INDICAÇOES NO BRASIL?

Resumen
O objetivo do presente artigo é analisar e discutir as publicações referentes à associação de aumento de mortalidade com o uso de fenoterol no tratamento de asma, seus efeitos colaterais e a situação atual de sua utilização em asma no mundo e no Brasil. Como fonte de dados, foi utilizada a base de dados do PubMed, utilizando os descritores asthma AND fenoterol, e Scielo, utilizando os descritores asma e fenoterol. São apresentados os resultados de estudos relevantes realizados sobre o tema em alguns países desenvolvidos e discutimos o potencial risco aumentado de mortalidade em pacientes que utilizam fenoterol em asma. Vários estudos demonstraram também a menor seletividade deste fármaco aos receptores 2-adrenérgicos. A comercialização de fenoterol foi proibida ou restrita em inúmeros países desenvolvidos, mas é amplamente utilizada ainda no Brasil. Os autores concluem que, com as evidências vigentes, a utilização irrestrita deste fármaco em asma deveria ser discutida por especialistas, sociedades médicas e órgãos governamentais no Brasil.

Palabras clave
mortalidade, terapêutica, broncodilatador


Artículo completo
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Extensión:  +/-6.6 páginas impresas en papel A4
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Increased asthma mortality with the use of fenoterol: enough historical evidence to discuss its indications in Brazil?

Abstract
The aim of the present article is to analyze and discuss the papers published regarding the association between the increase in asthma mortality and the use of fenoterol, its adverse effects and the current situation of its use in asthma in developed countries and in Brazil. As source of data, PubMed and Scielo databases were used, and a search was made with asthma AND fenoterol as keywords, for the selection of relevant articles. We have presented the results from studies made in developed countries and we discuss the potential increased risk of death in patients using fenoterol in asthma. Many studies have also demonstrated that fenoterol is less selective to b2-agonist receptors. Fenoterol use has been restricted or prohibited in many developed countries, but it is still widely used in Brazil. The authors conclude that, given the current evidence, the restricted use of fenoterol in asthma should be discussed by specialists, medical societies and government agencies in Brazil.

Key words
mortality, therapeutics, bronchodilator agents

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Medicina Farmacéutica, Neumonología
Relacionadas: Administración Hospitalaria, Atención Primaria, Farmacología, Medicina Familiar, Medicina Interna



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Enviar correspondencia a:
Paulo M Pitrez, Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brasil
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