Claudia Alejandra Sánchez *

Autora invitada por SIIC

Las estatinas podrían ser útiles en el tratamiento del cáncer de mama

LAS ESTATINAS INDUCEN ESTRES OXIDATIVO Y MUERTE CELULAR EN EL CANCER DE MAMA

Las estatinas inducen toxicidad de las células MCF-7 a través de un aumento en el estrés oxidativo y muerte celular apoptótica y necrótica, la cual puede ser revertida por un antioxidante.

*Claudia Alejandra Sánchez
describe para SIIC los aspectos relevantes de su trabajo
STATIN-INDUCED INHIBITION OF MCF-7 BREAST CANCER CELL PROLIFERATION IS RELATED TO CELL CYCLE ARREST AND APOPTOTIC AND NECROTIC CELL DEATH MEDIATED BY AN ENHANCED OXIDATIVE STRESS
Institución principal de la investigación
*Instituto Nacional de Cardiología "ignacio Chávez", México D. F., México
Imprimir nota

Comprar este artículo
Otros artículos escogidos

Referencias bibliográficas
1. Jakobisiak M, Golab J. Potential antitumor effects of statins. Int J Oncol 23:1055-1069, 2003.
2. LaRosa JC. Pleiotropic effects of statins and their clinical significance. Am J Cardiol 88:291-293, 2001.
3. Mach F. Toward a role for statins in immunomodulation. Mol Interv 2:478-480, 2002.
4. Bellosta S, Ferri N, Bernini F, Paoletti R, Corsini A. Non-lipid-related effects of statins. Ann Med 32:164-176, 2000.
5. Hess DC, Fagan SC. Pharmacology and clinical experience with simvastatin. Expert Opin Pharmacother 2:153-163, 2001.
6. Muck AO, Seeger H, Wallwiener D. Inhibitory effect of statins on the proliferation of human breast cancer cells. Int J Clin Pharmacol Ther 42:695-700, 2004.
7. Dimitroulakos J, Ye LY, Benzaquen M, Moore MJ, Kamel-Reid S, Freedman MH, Yeger H, Penn LZ. Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications. Clin Cancer Res 7:158-167, 2001.
8. Horiguchi A, Sumitomo M, Asakuma J, Asano T, Asano T, Hayakawa M. 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, fluvastatin, as a novel agent for prophylaxis of renal cancer metastasis. Clin Cancer Res 10:8648-8655, 2004.
9. Gronich N, Drucker L, Shapiro H, Radnay J, Yarkosi S, Lishner M. Symvastatin induces death of multiple myeloma cell lines. J Invest Med 52:335-344, 2004.
10. Shibata MA, Ito Y, Morimoto J, Otsuki Y. Lovastatin inhibits tumor growth and lung metastatsis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism. Carcinogenesis 25:1887-1898, 2004.
11. Castelazo G, Molotla D, Basavilvazo MA, Angeles L, Zarate A, Hernandez M. Survival of breast cancer patients treated with inhibitors of the aromatase vs tamoxifen. Ginecol Obstet Mex 72:493-499, 2004.
12. Valladares A, Salamanca F, Madrigal-Bujaidar E, Arenas D. Identification of chromosomal changes with comparative genomic hybridization in sporadic breast cancer in Mexican women. Cancer Genet Cytogenet 152:163-166, 2004.
13. Hamelin BA, Turgeon J. Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol Sci 19:26-37, 1998.
14. Arai M, Imai H, Koumura T, Yoshida M, Emoto K, Umeda M, Chiba N, Nakagawa Y. Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells. J Biol Chem 274:4924-4933, 1999.
15. Zalatnai A. Review: potential role of cell cycle synchronizing agents in combination treatment modalities of malignant tumors. In Vivo 19:85-91, 2005.

Otros artículos de Claudia Alejandra Sánchez

1. López MR, Estrada BA, Zentella DA. Interference with c-myc expression and RB phosphorylation during TNF-mediated growth arrest in human endothelial cells. Biochem Biophys Res Commun 236(3):819-824, 1997.
2. López R, Ventura JL, Sánchez L, Montaño LF, Zentella A. Ceramide mimics tumor necrosis factor-a in the induction of cell cycle arrest in endothelial cells: common induction of the tumor suppressor p53 and differential effect on the phosphorylation state of the tumor suppressor RB. European Journal of Biochemistry 267(14):4325-4333, 2000.
3. López Marure R, Gutiérrez G, Mendoza C, Ventura JL, Sánchez L, Reyes Maldonado E, Zentella A, Montaño LF. Ceramide promotes death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochemical Biophysical Research Communications 293(3):1028-1036, 2002.
4. Rodríguez E, López R, Paez A, Massó F, Montaño LF. 17B-estradiol inhibits the adhesion of leukocytes in TNF-alpha stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion, but not its transcription. Life Sciences 71(18):2181-2193, 2002.
5. Zapata E, Ventura JL, De la Cruz K, Rodríguez E, Felipe Massó PD, Montaño LF, López Marure R. Dehidroepiandrosterone inhibits the proliferation of HUVEC by enhancing the expression of p21 and p53, restricting the phosphorylation of RB, and is androgen- and estrogen-receptor independent. FEBS Journal 272:1343-1353, 2005.
6. Gayosso V, Montaño LF, López Marure R. DHEA-induced antiproliferative effect in MCF-7 cells is androgen- and estrogen-receptor independent. The Cancer Journal 12(2):160-165, 2006.
7. Gutiérrez G, Mendoza C, Zapata E, Montiel A, Reyes E, Montaño LF, López Marure R. Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells. Atherosclerosis 190(1):90-99, 2007.
8. Montiel Dávalos A, Alfaro Moreno E, López Marure R. PM2.5 and PM10 from Mexico city induce the expression of adhesion molecules and the adhesion of monocytic cells to human umbilical vein endothelial cells. Inhalation Toxicology 19(1):91-98, 2007.
9. Gutiérrez G, Mendoza C, Montaño LF, López Marure R. Ceramide induces early and late apoptosis in HPV+ cervical cancer cells by inhibiting ROS decay, diminishing the intracellular concentration of glutathione, and increasing NF-kappaB translocation. Anti-Cancer Drugs 18(2):149-59, 2007.
10. López Marure R, Huesca Gómez C, Ibarra Sánchez MJ, Zentella A, Pérez Méndez O. Dehydroepiandrosterone delays LDL oxidation in vitro and attenuates several oxLDL-induced inflammatory responses in endothelial cells. Inflammation & Allergy-Drug Targets 6:174-182, 2007.

Para comunicarse con Claudia Alejandra Sánchez mencionar a SIIC como referencia:
rlmarure@yahoo.com.mx

---

Acerca del trabajo completo

LAS ESTATINAS INDUCEN ESTRES OXIDATIVO Y MUERTE CELULAR EN EL CANCER DE MAMA

Título original en castellano
LA INHIBICION DE LA PROLOFERACION DE LAS CELULAS DE CANCER DE MAMA MCF-7 INDUCIDA POR ESTATINAS ESTA RELACIONADA CON UN PARO DEL CICLO CELULAR Y MUERTE CELULAR NECRONICA A TRAVES DE UN AUMENTO EN EL ESTRES OXIDATIVO.

Autor
Claudia Alejandra Sánchez¹
1 Química Farmaceútica Bióloga, Instituto Nacional de Cardiología "ignacio Chávez", México D. F., México, Estudiante de Posgrado

Acceso a la fuente original
Cancer Investigation
http://www.tandf.co.uk/journals/titles/07357907.asp

El artículo se relaciona estrictamente con las especialidades de siicsalud
El artículo se conecta secundariamente con las especialidades