Viviana Alicia Catania *

Autor invitado por SIIC

El trabajo aporta nuevas evidencias sobre la patogenia de la colestasis inducida por estrógenos

VENTAJAS DE LA EXCRECION SINUSOIDAL DE COMPUESTOS ENDOGENOS Y EXOGENOS EN LA COLESTASIS POR ESTROGENOS

La colestasis por etinilestradiol es de etiología multifactorial. Entre otros efectos ya descritos, observamos que el tratamiento con etinilestradiol aumenta la expresión y actividad de Mrp3 (un transportador sinusoidal) en hígado, lo que favorece la excreción de sus sustratos hacia el plasma, evitando su acumulación intracelular y el daño consiguiente.

*Viviana Alicia Catania
describe para SIIC los aspectos relevantes de su trabajo
ETHYNYLESTRADIOL INCREASES EXPRESSION AND ACTIVITY OF RAT LIVER MRP3
Institución principal de la investigación
*Instituto de Fisiología Experimental (IFISE-CONICET), Rosario, Argentina
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Referencias bibliográficas
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20. Ghanem CI, Ruiz ML, Villanueva SSM, Luquita MG, Catania VA, Jones B, Bengochea LA, Vore M, Mottino AD. Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats. J Pharmacol Exp Ther 2005; 315:987-995.
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Otros artículos de Viviana Alicia Catania

Catania VA, Luquita MG, Sánchez Pozzi EJ, Mottino AD. Enhancement of intestinal UDP-glucuronosyltransferase activity in partially hepatectomized rats. Biochem Biophys Acta 1998; 1380:345-353.
Luquita MG, Catania VA, Sánchez Pozzi EJ, Veggi LM, Hoffman T, Pellegrino JM, Ikushiro S, Emi Y, Iyanagi T, Vore M, Mottino AD. Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver. J Pharm Exp Ther 2001; 298:49-56.
Catania VA, Luquita MG, Sánchez Pozzi EJ, Ikushiro S, Emi Y, Iyanagi T, Mottino AD. Effect of spironolactone on the expression of rat hepatic UDP-glucuronosyltransferase. Biochem Pharmacol 2003; 66:171-177.
Catania VA, Sánchez Pozzi EJ, Luquita MG, Ruiz ML, Villanueva SSM, Jones B, Mottino AD. Co-regulation of expression of phase II metabolizing enzymes and multidrug resistance-associated protein 2. Annals of Hepatology 2004; 3:11-17.
Villanueva SSM, Ruiz ML, Luquita MG, Sánchez Pozzi EJ, Catania VA, Mottino AD. Involvement of Mrp2 in hepatic and intestinal disposition of dinitrophenyl-S-glutathione in partially hepatectomized rats. Toxicol Sci 2005; 84:4-11.
Ruiz ML, Villanueva SSM, Luquita MG, Sánchez Pozzi EJ, Crocenzi FA, Pellegrino JM, Ochoa JE, Vore M, Mottino AD, Catania VA. Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2. Biochem Pharmacol 2005; 69:531-539.
Crocenzi FA, D'Andrea V, Catania VA, Luquita MG, Pellegrino JM, Ochoa JE, Mottino AD, Sánchez Pozzi EJ. Prevention of Mrp2 activity impairment in ethinyltestradiol-induced cholestasis by ursodeoxycholate in the rat. Drug Metab Disposition 2005; 33:888-891.
Ghanem CI, Ruiz ML, Villanueva SSM, Luquita MG, Catania VA, Jones B, Bengochea LA, Vore M, Mottino AD. Shift from biliary to urinary elimination of acetaminophen glucuronide in acetaminophen pretreated rats. J Pharmacol Exp Ther 2005; 315:987-995.
Ruiz ML, Villanueva SSM, Luquita MG, Vore M, Mottino AD, Catania VA. Ethynylestradiol increases expression and activity of rat liver Mrp3. Drug Metab Dispos 2006; 34:1030-1034.
Villanueva SSM, Ruiz ML, Soroka CJ, Cai SY, Luquita MG, Torres AM, Sánchez Pozzi EJ, Pellegrino JM, Boyer JL, Catania VA, Mottino AD. Hepatic and extrahepatic synthesis and disposition of dinitrophenyl-S-glutathione in bile duct ligated rats. Drug Metab Dispos 2006; 34:1301-1309.

Para comunicarse con Viviana Alicia Catania mencionar a SIIC como referencia:
vcatania@fbioyf.unr.edu.ar

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Acerca del trabajo completo

VENTAJAS DE LA EXCRECION SINUSOIDAL DE COMPUESTOS ENDOGENOS Y EXOGENOS EN LA COLESTASIS POR ESTROGENOS



Autores
Viviana Alicia Catania¹, María Laura Ruiz², Silvina Stella Maris Villanueva³, Marcelo Gabriel Luquita⁴, Mary Vore⁵, Aldo Domingo Mottino⁶
1, Instituto de Fisiología Experimental (IFISE-CONICET), Rosario, Argentina
2, Instituto de Fisiología Experimental (IFISE-CONICET), Argentina, Becaria Doctoral de CONICET
3, Instituto de Fisiología Experimental (IFISE-CONICET), Argentina, Becaria Doctoral de CONICET
4, Instituto de Fisiología Experimental (IFISE-CONICET), Argentina, Profesional Adjunto de CONICET
5, Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, USA, Lexington, EE.UU., Professor-Director
6, Instituto de Fisiología Experimental (IFISE-CONICET), Argentina, Investigador Principal de CONICET

Acceso a la fuente original
Drug Metabolism and Disposition
http://dmd.aspetjournals.org/

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