Javier Gisbert *

Autor invitado por SIIC

TERAPIA DE RESCATE EMPIRICA TRAS EL FRACASO DE DOS TRATAMIENTOS DE ERRADICACION DE HELICOBACTER PYLORI

La infección por Helicobacter pylori constituye la causa fundamental de gastritis crónica, úlcera gastroduodenal y cáncer gástrico. Más de 20 años después de haber aislado por primera vez esta bacteria, todavía no disponemos de un tratamiento ideal; así, las combinaciones más efectivas que incluyen, actualmente, un inhibidor de la bomba de protones junto con dos antibióticos, fracasan en aproximadamente 20% de los casos.

*Javier Gisbert
describe para SIIC los aspectos relevantes de su trabajo
EMPIRICAL HELICOBACTER PYLORI "RESCUE" THERAPY AFTER FAILURE OF TWO ERADICATION TREATMENTS
Institución principal de la investigación
*Hospital Universitairo de la Princesa, Madrid, España, Madrid, España
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Referencias bibliográficas
Beales IL. Efficacy of Helicobacter pylori eradication therapies: a single centre observational study. BMC Gastroenterol 2001; 1:7.Chan FK, Sung JJ, Suen R, Wu JC, Ling TK, Chung SC. Salvage therapies after failure of Helicobacter pylori eradication with ranitidine bismuth citrate-based therapies. Aliment Pharmacol Ther 2000; 14:91-5.De Boer WA, Tytgat GN. Regular review: treatment of Helicobacter pylori infection. BMJ 2000; 320:31-4.Gasbarrini A, Ojetti V, Armuzzi A, Branca G, Canducci F, Torre ES et al. Efficacy of a multistep strategy for Helicobacter pylori eradication. Aliment Pharmacol Ther 2000; 14:79-83.Gomollon F, Ducons JA, Ferrero M, Garcia Cabezudo J, Guirao R, Simon MA et al. Quadruple therapy is effective for eradicating Helicobacter pylori after failure of triple proton-pump inhibitor-based therapy: a detailed, prospective analysis of 21 consecutive cases. Helicobacter 1999; 4:222-5.Gomollon F, Sicilia B, Ducons JA, Sierra E, Revillo MJ, Ferrero M. Third line treatment for Helicobacter pylori: a prospective, culture-guided study in peptic ulcer patients. Aliment Pharmacol Ther 2000; 14:1335-8.Graham DY, Osato MS, Hoffman J, Opekun AR, Anderson SY, Kwon DH et al. Metronidazole containing quadruple therapy for infection with metronidazole resistant Helicobacter pylori: a prospective study. Aliment Pharmacol Ther 2000; 14:745-50.Huang JQ, Hunt RH. Treatment after failure: the problem of non-responders. Gut 1999; 45 Suppl 1:I40-4.Lerang F, Moum B, Haug JB, Berge T, Tolas P, Sandvei PK et al. Highly effective second-line anti-Helicobacter pylori therapy in patients with previously failed metronidazole-based therapy. Scand J Gastroenterol 1997; 32:1209-14.Magaret N, Burm M, Faigel D, Kelly C, Peterson W, Fennerty MB. A randomized trial of lansoprazole, amoxycillin, and clarithromycin versus lansoprazole, bismuth, metronidazole and tetracycline in the retreatment of patients failing initial Helicobacter pylori therapy. Dig Dis 2001; 19:174-8.Perri F, Festa V, Andriulli A. Treatment of antibiotic-resistant Helicobacter pylori. N Engl J Med 1998; 339:53.Perri F, Festa V, Clemente R, Quitadamo M, Andriulli A. Rifabutin-based "rescue therapy" for Helicobacter pylori infected patients after failure of standard regimens. Aliment Pharmacol Ther 2000; 14:311-6.Perri F, Festa V, Clemente R, Villani MR, Quitadamo M, Caruso N, et al. Randomized study of two rescue therapies for Helicobacter pylori- infected patients after failure of standard triple therapies. Am J Gastroenterol 2001; 96:58-62.Seppala K, Kosunen TU, Nuutinen H, Sipponen P, Rautelin H, Sarna S, et al. Cure of Helicobacter pylori infection after failed primary treatment: one-center results from 120 patients. Scand J Gastroenterol 2000; 35:929-34.Tompkins DS, Perkin J, Smith C. Failed treatment of Helicobacter pylori infection associated with resistance to clarithromycin. Helicobacter 1997; 2:185-7.Van der Wouden EJ, Thijs JC, Van Zwet AA, Sluiter WJ, Kleibeuker JH. The influence of in vitro nitroimidazole resistance on the efficacy of nitroimidazole-containing anti-Helicobacter pylori regimens: a meta-analysis. Am J Gastroenterol 1999; 94:1751-9.Zullo A, Hassan C, Campo SM, Lorenzetti R, Febbraro I, De Matthaeis M et al. A triple therapy regimen after failed Helicobacter pylori treatments. Aliment Pharmacol Ther 2001; 15:1193-7.Zullo A, Hassan C, De Francesco V, Lorenzetti R, Marignani M, Angeletti S, et al. A third-line levofloxacin-based rescue therapy for Helicobacter pylori eradication. Dig Liver Dis 2003; 35: 232-6.Zullo A, Hassan C, Lorenzetti R, Winn S, Morini S. A clinical practice viewpoint: to culture or not to culture Helicobacter pylori Dig Liver Dis 2003; 35:357-61.

Otros artículos de Javier Gisbert

Gisbert JP, Boixeda D, Bermejo F, Nieves Rincon M, Jesus Higes M, Angeles Arpa M et al. Re-treatment after Helicobacter pylori eradication failure. Eur J Gastroenterol Hepatol 1999; 11:1049-54.Gisbert JP, Pajares JM. Helicobacter pylori therapy: first-line options and rescue regimen. Dig Dis 2001; 19:134-43.Gisbert JP, Pajares JM. Helicobacter pylori "rescue" regimen when proton pump inhibitor-based triple therapies fail. Aliment Pharmacol Ther 2002; 16:1047-57.Gisbert JP, Calvet X, Bujanda L, Marcos S, Gisbert JL, Pajares JM. Rescue therapy with rifabutin after multiple Helicobacter pylori treatment failures. Helicobacter 2003; 8:90-94.Gisbert JP, Gisbert JL, Marcos S, Pajares JM. Empirical Helicobacter pylori rescue therapy after failure of two eradication treatments. Dig Liver Dis 2004; 36:7-12.Gisbert JP, Khorrami S, Carballo F, Calvet X, Gene E, Dominguez-Munoz E. Helicobacter pylori eradication therapy vs. antisecretory non-eradication therapy for the prevention of recurrent bleeding from peptic ulcer. Aliment Pharmacol Ther 2004; 19:617-29.Gisbert JP, Cruzado AI, Garcia-Gravalos R, Pajares JM. Lack of benefit of treating Helicobacter pylori infection in patients with functional dyspepsia. Randomized one-year follow-up study. Hepatogastroenterology 2004; 51:303-8.Gisbert JP, Legido J, Garcia-Sanz I, Pajares JM. Helicobacter pylori and perforated peptic ulcer prevalence of the infection and role of non-steroidal anti-inflammatory drugs. Dig Liver Dis 2004; 36:116-20.Gisbert JP, Khorrami S, Calvet X, Gabriel R, Carballo F, Pajares JM. Meta-analysis: proton pump inhibitors vs. H2-receptor antagonists-their efficacy with antibiotics in Helicobacter pylori eradication. Aliment Pharmacol Ther 2003; 18:757-66.Gisbert JP, Ducons J, Gomollon F, Dominguez-Munoz JE, Borda F, Mino G, et al. Validation of the 13c-urea breath test for the initial diagnosis of Helicobacter pylori infection and to confirm eradication after treatment. Rev Esp Enferm Dig 2003; 95:121-6, 115-20.

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Acerca del trabajo completo

TERAPIA DE RESCATE EMPIRICA TRAS EL FRACASO DE DOS TRATAMIENTOS DE ERRADICACION DE HELICOBACTER PYLORI

Título original en castellano
TERAPIA DE RESCATE EMPIRICA TRAS EL FRACASO DE DOS TRATAMIENTOS ERRADICADORES FRENTE A HELICOBACTER PYLORI

Autor
Javier Gisbert¹
1 Médico, Hospital Universitairo de la Princesa, Médico Adjunto

Acceso a la fuente original
Digestive and Liver Disease
http://www.elsevier.com/wps/find/journaldescription.cws_home/623449/description

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