Juan Gilabet-Estellés *

Autor invitado por SIIC

MICRORNAS EN LA ENDOMETRIOSIS Y SU RELACIÓN CON FACTORES ANGIOGÉNICOS Y FIBRINOLÍTICOS

La mayor actividad angiogénica y fibrinolítica en el endometrio de pacientes con endometriosis puede contribuir a la capacidad de implantación de las células endometriales en localizaciones ectópicas. La diferente expresión de miRNAs podría modular la expresión de factores angiogénicos y tener un papel en la patogenia de la enfermedad.

*Juan Gilabet-Estellés
describe para SIIC los aspectos relevantes de su trabajo
MICRORNAS EXPRESSION IN ENDOMETRIOSIS AND THEIR RELATION TO ANGIOGENIC FACTORS
Institución principal de la investigación
*Consorcio Hospital General Universitario de Valencia, Valencia, España
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Referencias bibliográficas
1. Giudice LC, Kao LC. Endometriosis. Lancet 2004;364:1789–1799
2. Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril 2012;98: 511–519.
3. Nardone C, Jenkinson C, Kennedy SH, Zondervan KT; World Endometriosis Research Foundation Global Study of Women's Health consortium. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil. Steril. 2011 96: 366-373.
4. Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, Jaffe RB, Taylor RN. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 1996;81:3112–3118.
5. Donnez J, Smoes P, Gillerot S, Casanas-Roux F, Nisolle M. Vascular endothelial growth factor (VEGF) in endometriosis. Hum Reprod 1998; 13:1686–1690.
6. McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update 2000;6:45–55.
7. Gilabert-Estellés J, Ramón LA, España F, Gilabert J, Castello R, Estellés A. Expression of the fibrinolytic components in endometriosis. Pathophysiol Haemost Thromb. 2006;35:136–140.
8. Gilabert-Estellés J, Ramón LA, España F, Gilabert J, Vila V, Réganon E, Castelló R, Chirivella M, Estellés A. Expression of angiogenic factors in endometriosis: its relation to fibrinolytic and metalloproteinase (MMP) systems. Hum Reprod 2007; 22:2120–2127.
9. Cosın R, Gilabert-Estellés J, Ramón LA, Gómez-Lechón MJ, Gilabert J, Chirivella M, Braza-Boïls A, España F, Estellés A. Influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with endometriosis. Hum Reprod 2010; 25:398–405.
10. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215–233.
11. Ohlsson-Teague EM, Print CG, Hull ML. The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update 2010;16:146–165.
12. Gilabert-Estellés J, Braza-Boïls A, Ramón LA, Zorio E, Medina P, España F, Estellés A. Role of microRNAs in gynecological pathology. Curr Med Chem 2012;19:2406–2413.
13. Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. CardiovascRes 2008;79:581–588.
14. Burney RO, Hamilton AE, Aghajanova L, Vo KC, Nezhat CN, Lessey BA, Giudice LC. MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis. Mol Hum Reprod 2009;15:625–631.
15. Zorio E, Medina P, Rueda J, Milla´n JM, Arnau MA, Beneyto M, Marı´n F, Gimeno JR, Osca J, Salvador A et al. Insights of the role of microRNAs in cardiac diseases: from biological signaling to therapeutic targets. Cardiovas & Hematol Agent in Med Chem 2009; 7: 82–90.
16. Filigheddu N, Gregnanin I, Porporato PE, Surico D, Perego B, Galli L, Patrignani C, Graziani A, Surico N. Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis. J Biomed Biotechnol 2010;2010:369549.
17. Ramón LA, Braza-Boïls A, Gilabert J, España F, Chirivella M, Estellés A, Gilabert-Estellés J. microRNAs related to angiogenesis are dysregulated in endometriod endometrial cancer. Human Reprod 2012;27:3036–3045.
18. Suárez Y, Sessa WC. MicroRNAs as novel regulators of angiogenesis. Circ Res 2009 ;104:442-454.
19. Ramón LA, Braza-Boïls A, Gilabert-Estellés J, Gilabert J, España F, Chirivella M, Estellés A. microRNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod 2011;26:1082–1090.

Otros artículos de Juan Gilabet-Estellés

1: Braza-Boïls A, Salloum-Asfar S, Marí-Alexandre J, Arroyo AB, González-Conejero R, Barceló-Molina M, García-Oms J, Vicente V, Estellés A, Gilabert-Estellés J, Martínez C. Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis. Hum Reprod. 2015;30:2292-302.
2: Marí-Alexandre J, García-Oms J, Barceló-Molina M, Gilabert-Aguilar J, Estellés A, Braza Boíls A, Gilabert-Estellés J. MicroRNAs and angiogenesis in endometriosis. Thromb Res. 2015;135 Suppl 1:S38-40.
3: Braza-Boïls A, Marí-Alexandre J, Gilabert J, Sánchez-Izquierdo D, España F, Estellés A, Gilabert-Estellés J. MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors. Hum Reprod. 2014;29:978-88.
4: Braza-Boïls A, Gilabert-Estellés J, Ramón LA, Gilabert J, Marí-Alexandre J, Chirivella M, España F, Estellés A. Peritoneal fluid reduces angiogenesis-related microRNA expression in cell cultures of endometrial and endometriotic tissues from women with endometriosis. PLoS One. 2013;8:e62370.
5: Ramón LA, Braza-Boïls A, Gilabert J, Chirivella M, España F, Estellés A, Gilabert-Estellés J. microRNAs related to angiogenesis are dysregulated in endometrioid endometrial cancer. Hum Reprod. 2012 ;27:3036-45.
6: Gilabert-Estelles J, Braza-Boils A, Ramon LA, Zorio E, Medina P, Espana F, Estelles A. Role of microRNAs in gynecological pathology. Curr Med Chem. 2012;19:2406-13.
7: Gilabert-Estellés J, Ramón LA, Braza-Boïls A, Gilabert J, Chirivella M, España F, Estellés A. Plasminogen activator inhibitor-1 (PAI-1) 4 G/5 G polymorphism and endometrial cancer. Influence of PAI-1 polymorphism on tissue PAI-1 antigen and mRNA expression and tumor severity. Thromb Res. 2012;130:242-7.
8: Ramón LA, Braza-Boïls A, Gilabert-Estellés J, Gilabert J, España F, Chirivella M, Estellés A. microRNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod. 2011;26:1082-90.
9: Gilabert-Estelles J, Zorio E, Castello JM, Estelles A, Gilabert-Aguilar J. Laparoscopic approach to right diaphragmatic endometriosis with argon laser: case report. J Minim Invasive Gynecol. 2010;17:124-7.
10: Downes E, Sikirica V, Gilabert-Estelles J, Bolge SC, Dodd SL, Maroulis C, Subramanian D. The burden of uterine fibroids in five European countries. Eur J Obstet Gynecol Reprod Biol. 2010;152:96-102.

Para comunicarse con Juan Gilabet-Estellés mencionar a SIIC como referencia:
juangilaeste@yahoo.es

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MICRORNAS EN LA ENDOMETRIOSIS Y SU RELACIÓN CON FACTORES ANGIOGÉNICOS Y FIBRINOLÍTICOS

Título original en castellano
EXPRESION DE MICRORNAS EN LA ENDOMETRIOSIS: SU RELACION CON FACTORES ANGIOGENICOS Y FIBRINOLITICOS

Autores
Juan Gilabet-Estellés¹, Aitana Braza-Boïls², Josep Marí-Alexandre³, Juan Gilabert⁴, Amparo Estellés⁵
1 Doctor en Medicina y Cirugía, Consorcio Hospital General Universitario de Valencia, Valencia, España, Jefe de Área Materno-infantil
2 Doctora en Biología
3 Licenciado en Bioquímica
4 Doctor en Medicina y Cirugía
5 Doctora en Medicina

Acceso a la fuente original
Human Reproduction
https://academic.oup.com/humrep/issue

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