Roberto Barbosa Bazotte *

Autor invitado por SIIC

O TRABALHO APRESENTA UMA NOVA POSSIBILIDADE EM TERMOS DE PROMOVER RECUPERAÇÃO DA GLICEMIA

ADMINISTRAÇÃO DE GLICEROL, PIRUVATO OU LACTATO PROMOVENDO RECUPERAÇÃO DA GLICEMIA

Além do tratamento convencional da hipoglicemia empregando glucose ou glucagon. Este estudo abre a perspectiva de estudos clínicos empregando precursores hepáticos de glicose (glicerol, piruvato e lactato) como nova alternativa em promover a recuperação da glicemia durante a hipoglicemia induzida por insulina.

*Roberto Barbosa Bazotte
describe para SIIC los aspectos relevantes de su trabajo
INVESTIGATION OF GLYCEMIA RECOVERY WITH ORAL ADMINISTRATION OF GLYCEROL, PYRUVATE, AND L-LACTATE DURING LONG-TERM, INSULIN-INDUCED HYPOGLYCEMIA
Institución principal de la investigación
*State University Of Maringá, Maringá, Brasil
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Referencias bibliográficas
Hartmann, Eduardo M.; Garcia, Rosângela F.; Gazola, Vilma A.F.G.; Barrena, Helenton C.; Bazotte, Roberto B. Investigation of glycemia recovery with oral administration of glycerol, pyruvate, and l-lactate during long-term, insulin-induced hypoglycemia?. Journal of Diabetes and its Complications, v. 24, p. 301-305, 2010.

Otros artículos de Roberto Barbosa Bazotte

Felisberto-Junior, A.M; Manso, Fernando Canas; Gazola, V.A.F.G.; Obici, S; Geisler, S.A; Bazotte, R.B. Oral glutamine dipeptide prevents against prolonged hypoglycemia induced by Detemir insulin in rats. Biological & Pharmaceutical Bulletin, v. 32, p. 232-236, 2009.

Oliveira-Yamashita, Fabiana; Garcia, Rosangela Fernandes; Felisberto-Junior, Antonio Machado; Curi, Rui; Bazotte, Roberto Barbosa. Evidence that L-glutamine is better than L-alanine as gluconeogenic substrate in perfused liver of weaned fasted rats submitted to short-term insulin-induced hypoglycaemia. Cell Biochemistry and Function, v. 27, p. 30-34, 2009.

Galende, Sharize Betoni; Oliveira Neto, Oswaldo Custódio; Santos, Leandro Freire Dos; Peicher, Márcia Vardanega; Souza, Helenir Medri De; Bazotte, Roberto Barbosa. Glucose administration inhibits the hepatic activation of gluconeogenesis promoted by insulin-induced hypoglycemia. Brazilian Archives of Biology and Technology, v. 52, p. 849-854, 2009.

Barrena, Helenton Cristhian; Gazola, Vilma Aparecida Ferreira Godoi; Furlan, Maria Montserrat Diaz Pedrosa; Garcia, Rosângela Fernandes; de Souza, Helenir Medri; Bazotte, Roberto Barbosa. Ketogenesis evaluation in perfused liver of diabetic rats submitted to short-term insulin-induced hypoglycemia. Cell Biochemistry and Function, v. 27, p. 383-387, 2009.

Obici, Simoni; Lopes-Bertolini, Gisele; Curi, Rui; Bazotte, R.B. Liver glycogen metabolism during short-term insulin-induced hypoglycemia in fed rats. Cell Biochemistry and Function, v. 26, p. 755-759, 2008.

Albuquerque, Gabriela Girao; Gazola, V.A.F.G.; Garcia, Rosangela Fernandes; Souza, K.L.A ; Barrena, Helenton Cristhian; Curi, Rui; Bazotte, R.B. Gluconeogenesis and ketogenesis ln perfused rat liver of rats submitted to short-term insulin-induced hypoglycemia. Cell Biochemistry and Function, v. 26, p. 228-232, 2008.

Nascimento, Katia Fialho Do; Garcia, Rosangela Fernandes; Gazola, V.A. F.G.; Souza, Helenir Medri De; Obici, S; Bazotte, R.B. Contribution Of Hepatic Glycogenolysis And Gluconeogenesis In The Defense Against Short-term insulin induced hypoglycemia in rats. Life Sciences v. 82, p. 1018-1022, 2008.

Garcia, Rosangela Fernandes; Gazola, V.A.F.G.; Hartmann, Eduardo Machado; Barrena, Helenton Cristhian; Obici, S; Nascimento, Katia Fialho Do; Bazotte, R.B. Oral glutamine dipeptide promotes acute glycemia recovery in rats submitted to long-term insulin induced hypoglycemia. Acta Farmaceutica Bonaerense, v. 27, p. 229-234, 2008.

Gazola, V.A.F.G.; Garcia, Rosangela Fernandes; Hartmann, Eduardo Machado; Barrena, Helenton Cristhian; Albuquerque, Gabriela Girao; Bazotte, R.B. Glycemia recovery with oral amino acids administration during experimental short-term insulin induced-hypoglycemia. Journal of Diabetes and its Complications, v. 21, p. 520-525, 2007.

Garcia, Rosangela Fernandes; Gazola, Vilma Aparecida Ferreira De Godoi; Barrena, Helenton Cristhian; Hartmann, Eduardo Machado; Berti, Jairo; Toyama, Marcos H; Boschero, Antonio Carlos; Carneiro, Everardo M; Manso, Fernando Canas; Bazotte, R.B. Blood amino acids concentration during insulin induced hypoglycemia in rats: the rule of alanine and glutamine to glucose recovery. Amino Acids, v. 33, p. 151-155, 2007.

Para comunicarse con Roberto Barbosa Bazotte mencionar a SIIC como referencia:
rbbazotte@uem.br

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Acerca del trabajo completo

ADMINISTRAÇÃO DE GLICEROL, PIRUVATO OU LACTATO PROMOVENDO RECUPERAÇÃO DA GLICEMIA

Título original en castellano
INVESTIGAÇÃO DA RECUPERAÇÃO DA GLICEMIA EMPREGANDO GLICEROL, PIRUVATO OU L-LACTATO PELA VIA ORAL DURANTE A HIPOGLICEMIA DE LONGO PRAZO INDUZIDA PELA ADMINISTRAÇÃO DE INSULINA

Autores
Roberto Barbosa Bazotte¹, Rosangela Fernandes Garcia², Vilma Aparecida Ferreira Godoi Gazola³, Helenton Christian Barrena⁴, Eduardo Machado Hartmann⁵
1 Professor, State University Of Maringá, Maringá, Brasil, Full Professor
2 Biologa, Universidade Estadual de Maringá, Professor
3 Biologa, Universidade Estadual de Maringá, Professor
4 Biologo, Universidade Estadual de Maringá, Estudante - Doutorado
5 Biologo, Universidade Estadual de Maringá, Estudante - Mestrado

Acceso a la fuente original
Journal of Diabetes and its Complications
http://www.sciencedirect.com/science/journal/10568727

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