María Elisa Peichoto *

Autor invitado por SIIC

El trabajo constituye el primer relato sobre el procesamiento autoproteolítico de una metaloproteasa del veneno de una serpiente opistoglifa

AUTODEGRADACIÓN DE UNA METALOPROTEASA DEL VENENO DE UNA SERPIENTE OPISTOGLIFA

Con el objetivo de contribuir a un mejor entendimiento sobre las bases estructurales y mecánicas de las metaloproteasas presentes en los venenos de serpientes, hemos analizado, por primera vez, el procesamiento autoproteolítico de una metaloproteasa presente en el veneno de una serpiente opistoglifa.

*María Elisa Peichoto
describe para SIIC los aspectos relevantes de su trabajo
AUTOLYSIS AT THE DISINTEGRIN DOMAIN OF PATAGONFIBRASE, A METALLOPROTEINASE FROM PHILODRYAS PATAGONIENSIS (PATAGONIA GREEN RACER; DIPSADIDAE) VENOM
Institución principal de la investigación
*Universidad Nacional del Nordeste, Corrientes, Argentina
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Otros artículos escogidos

Referencias bibliográficas
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2. Gutiérrez JM, A. Rucavado, T. Escalante, Snake venom metalloproteinases. Biological roles and participation in the pathophysiological of envenomation, in: S.P. Mackessy (Ed.), Handbook of Venoms and Toxins of Reptiles, CRC Press/Taylor & Francis Group, Boca Raton, 2009, pp. 115-138.

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[13] M.E. Peichoto, P. Teibler, S.P. Mackessy, L. Leiva, O. Acosta, L.R. Goncalves, A.M. Tanaka-Azevedo, M.L. Santoro, Purification and characterization of patagonfibrase, a metalloproteinase showing alpha-fibrinogenolytic and hemorrhagic activities, from Philodryas patagoniensis snake venom, Biochim Biophys Acta 1770 (2007) 810-819.

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Otros artículos de María Elisa Peichoto

- María Elisa Peichoto. Caracterización y aislamiento de proteínas del veneno de Philodryas patagoniensis que habita la región nordeste de Argentina. Tesis Doctoral galardonada con el Premio “Dr. Pedro N. Arata 2008”. Industria & Química. Revista de la Asociación Química Argentina. ISSN 0368-0819. Vol. 359, Sección “Tesis Premiadas”, 29-31, 2009.

- María Elisa Peichoto, S.P. Mackessy, P. Teibler, F.L. Tavares, P.L. Burckhardt, M.C. Breno, O. Acosta, M.L. Santoro. Purification and characterization of a cysteine-rich secretory protein isolated from Philodryas patagoniensis snake venom. Comparative Biochemistry and Physiology. Part C: Toxicology and Pharmacology. ISSN 1532-0456 (Print). Vol. 150 (1), 79-84, 2009.

- María Elisa Peichoto, Pamela Teibler, Stephen Mackessy, Laura Leiva, Ofelia Acosta, Luis R. Camargo Gonçalves, Anita M. Tanaka-Azevedo, Marcelo L. Santoro. Purification and characterization of patagonfibrase, a metalloproteinase showing α-fibrinogenolytic and hemorrhagic activities, from Philodryas patagoniensis snake venom. Biochimica et Biophysica Acta. International Journal of Biochemistry, Biophysics and Molecular Biology. ISSN 0304-4165 (Print). Vol. 1770 (5), 810-819, 2007.

- María Elisa Peichoto, Jorge Abel Céspedez, Juan Antonio Pascual. Report of a bite by the South American colubrid snake Philodryas olfersii latirostris (Squamata: Colubridae). Acta Herpetologica. Official Journal of the Societas Herpetologica Italica. ISSN 1827-9643 (Electronic) ISSN 1827-9635 (Print). Vol. 2 (1), 11-15, 2007.

- María Elisa Peichoto, Pamela Teibler, Raquel Ruíz, Laura Leiva, Ofelia Acosta. Systemic pathological alterations caused by Philodryas patagoniensis colubrid snake venom in rats. Toxicon. Official Journal of the International Society on Toxinology. ISSN 0041-0101 (Print). Vol. 48 (5), 520-528, 2006.

- M.E. Peichoto, L. C. Leiva, L. E. Guaimás Moya, L. Rey, O. Acosta. Duvernoy’s gland secretion of Philodryas patagoniensis from the northeast of Argentina: its effects on blood coagulation. Toxicon. Official Journal of the International Society on Toxinology. ISSN 0041-0101 (Print). Vol. 45 (4), 527-534, 2005.

- M.E. Peichoto, O. Acosta, L. Leiva, P. Teibler, S. Maruñak, R. Ruíz. Muscle and skin necrotizing and edema-forming activities of the Duvernoy’s gland secretion of the xenodontine colubrid Philodryas patagoniensis from the north-east of Argentina. Toxicon. Official Journal of the International Society on Toxinology. ISSN 0041-0101 (Print). Vol. 44 (6), 589-596, 2004.

- Acosta de Pérez, O.; Leiva de Vila, L. C.; Peichoto, M. E.; Maruñak, S.; Ruíz, R.; Teibler, P.; Gay, C.; Rey, L. Edematogenic and myotoxic activities of the Duvernoy’s gland secretion of Philodryas olfersii from the north-east region of Argentina. Biocell. Official Journal of the Sociedades Latinoamericanas de Microscopía Electrónica (SLAME), Iberoamericana de Biología Celular (SIABC), Federación Iberoamericana de Biología Celular y Molecular, and Sociedad Argentina de Investigaciones Bioquímica y Biología Molecular (SAIB). ISSN 0327-9545 (Print) 1667-5746 (Electronic). Vol. 27 (3): 363-370, 2003.

- Acosta, O.; Leiva, L.; Peichoto, M. E.; Maruñak, S.; Teibler, P.; Rey, L. Hemorrhagic activity of the Duvernoy’s gland secretion of the xenodontine colubrid Philodryas patagoniensis from the north-east region of Argentina. Toxicon. Official Journal of the International Society on Toxinology. ISSN 0041-0101 (Print). Vol. 41 (8), 1007-1012, 2003.

Para comunicarse con María Elisa Peichoto mencionar a SIIC como referencia:
mepeichoto@yahoo.com.ar

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AUTODEGRADACIÓN DE UNA METALOPROTEASA DEL VENENO DE UNA SERPIENTE OPISTOGLIFA

Título original en castellano
AUTOLISIS A NIVEL DEL DOMINIO DESINTEGRINA DE PATAGONFIBRASA, UNA METALOPROTEASA DEL VENENO DE PHILODRYAS PATAGONIENSIS (CULEBRA DE PASTIZAL; DIPSADIDAE)

Autor
María Elisa Peichoto¹
1 Bioquímica, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional del Nordeste, Corrientes, Argentina, Investigador Asistente del Conicet y Pro

Acceso a la fuente original
BBA Proteins and Proteomics
http://www.elsevier.com/wps/find/journaldescription.cws_home/635707/description

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