Betina Córsico *

Autora invitada por SIIC

UNIÓN Y TRANSFERENCIA DE LIGANDOS NATURALES DESDE LA PROTEINA QUE UNE ACIDOS GRASOS DE HIGADO HACIA MEMBRANAS

Con la finalidad de contribuir a dilucidar las funciones específicas de las proteínas intracelulares que unen ácidos grasos, analizamos, por primera vez, las características de unión y transferencia de ácidos grasos y acil-CoAs naturales de la proteína que une ácidos grasos de hígado.

*Betina Córsico
describe para SIIC los aspectos relevantes de su trabajo
NATURAL LIGAND BINDING AND TRANSFER FROM LIVER FATTY ACID BINDING PROTEIN (LFABP) TO MEMBRANES
Institución principal de la investigación
*Universidad Nacional de la Plata, La Plata, Argentina
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Otros artículos escogidos

Referencias bibliográficas
1. He Y, Yang X, Wang H, Estephan R, Francis F, Kodukula S, Storch J, Stark RE. Solution-state molecular structure of apo and oleate-liganded liver fatty acidbinding protein. Biochemistry 46:12543-12556, 2007.
2. Hodsdon ME, Cistola DP. Ligand binding alters the backbone mobility of intestinal fatty acid-binding protein as monitored by 15 N NMR relaxation and 1H exchange. Biochemistry 36:2278-2290, 1997.
3. Storch J, Córsico B. The emerging functions and mechanisms of mammalian fatty acid-binding proteins. Annu Rev Nutr 28:73-95, 2008.
4. Thompson J, Winter N, Terwey D, Bratt J, Banaszak L. The crystal structure of the liver fatty acid-binding protein. A complex with two bound oleates. J Biol Chem 14:7140-7150, 1997.
5. He Y, Yang X, Wang H, Estephan R, Francis F, Kodukula S, Storch J, Stark RE. Solution-state molecular structure of apo and oleate-liganded liver fatty acidbinding protein. Biochemistry 46:12543-12556, 2007.
6. Sacchettini JC, Gordon JI, Banaszak LJ. Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli. Biochim Biophys Acta 1747:189-194, 1989.
7. Richieri GV, Ogata RT, Kleinfeld AM. Thermodynamic and kinetic properties of fatty acid interactions with rat liver fatty acid-binding protein. J Biol Chem 271:31068-31074, 1996.
8. Wilkinson TC, Wilton DC. Studies on fatty acid-binding proteins. The binding properties of rat liver fatty acid-binding protein. Biochem J 247:485-488, 1987.
9. Burrier RE, Manson CR, Brecher P. Binding of acyl-CoA to liver fatty acid binding protein: effect on acyl-CoA synthesis. Biochim Biophys Acta 919:221-230, 1987.
10. Thumser AE, Voysey JE, Wilton DC. The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin. Biochem J 301:801-806, 1994.
11. Burrier RE, Brecher P. Binding of lysophosphatidylcholine to the rat liver fatty acid binding protein. Biochim Biophys Acta 879:229-239, 1986.
12. Hsu KT, Storch J. Fatty acid transfer from liver and intestinal fatty acid-binding proteins to membranes occurs by different mechanisms. J Biol Chem 271:13317-13323, 1996.
13. Franchini GR, Storch J, Córsico B. The integrity of the alpha-helical domain of intestinal fatty acid binding protein is essential for the collision-mediated transfer of fatty acids to phospholipid membranes. Biochim Biophys Acta 1781:192-199, 2008.
14. Córsico B, Liou HL, Storch J. The alpha-helical domain of liver fatty acid binding protein is responsible for the diffusion-mediated transfer of fatty acids to phospholipid membranes. Biochemistry 43:3600-3607, 2004.
15. Thumser AE, Storch J. Liver and intestinal fatty acid-binding proteins obtain fatty acids from phospholipid membranes by different mechanisms. J Lipid Res 41:647-656, 2000.
16. Córsico B, Cistola DP, Frieden C, Storch J. The helical domain of intestinal fatty acid binding protein is critical for collisional transfer of fatty acids to phospholipid membranes. Proc Natl Acad Sci USA 95:12174-12178, 1998.
17. Hagan RM, Worner-Gibbs J, Wilton DC. Tryptophan insertion mutagenesis of liver fatty acid-binding protein: L28W mutant provides important insights into ligand binding and physiological function. J Biol Chem 280:1782-1789, 2005.

Otros artículos de Betina Córsico

Falomir Lockhart LJ, Burgardt NI, Ferreyra RG, Ceolin M, Ermácora MR, Córsico B. Fatty acid transfer from Yarrowia lipolytica sterol carrier protein 2 to phospholipid membranes. Biophys J 97(1):248-56, 2009.
Storch J, Córsico B. The emerging functions and mechanisms of mammalian fatty acid-binding proteins. Annu Rev Nutr 28:73-95, 2008.
Franchini GR, Storch J, Córsico B. The integrity of the alpha-helical domain of intestinal fatty acid binding protein is essential for the collision-mediated transfer of fatty acids to phospholipid membranes. Biochim Biophys Acta 1781(4):192-9, 2008. Epub 2008 Feb 5.
Falomir-Lockhart LJ, Laborde L, Kahn PC, Storch J, Córsico B. Protein-membrane interaction and fatty acid transfer from intestinal fatty acid-binding protein to membranes. Support for a multistep process. J Biol Chem 281(20):13979-89, 2006. Epub 2006 Mar 21.
Córsico B, Franchini GR, Hsu KT, Storch J. Fatty acid transfer from intestinal fatty acid binding protein to membranes: electrostatic and hydrophobic interactions. J Lipid Res 46(8):1765-72, 2005. Epub 2005 May 1.
Córsico B, Liou HL, Storch J. The alpha-helical domain of liver fatty acid binding protein is responsible for the diffusion-mediated transfer of fatty acids to phospholipid membranes. Biochemistry 43(12):3600-7, 2004.
Córsico B, Toledo JD, Garda HA. Evidence for a central apolipoprotein A-I domain loosely bound to lipids in discoidal lipoproteins that is capable of penetrating the bilayer of phospholipid vesicles. J Biol Chem 276(20):16978-85, 2001. Epub 2001 Mar 2.
Corsico B, Cistola DP, Frieden C, Storch J. The helical domain of intestinal fatty acid binding protein is critical for collisional transfer of fatty acids to phospholipid membranes. Proc Natl Acad Sci USA 95(21):12174-8, 1998.

Para comunicarse con Betina Córsico mencionar a SIIC como referencia:
edg1981@gmail.com

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Acerca del trabajo completo

UNIÓN Y TRANSFERENCIA DE LIGANDOS NATURALES DESDE LA PROTEINA QUE UNE ACIDOS GRASOS DE HIGADO HACIA MEMBRANAS

Título original en castellano
UNION Y TRANSFERENCIA DE LIGANDOS NATURALES DESDE LA PROTEINA QUE UNE ACIDOS GRASOS DE HIGADO (LFABP) HACIA MEMBRANAS.

Autores
Betina Córsico¹, Eduardo De Gerónimo²
1 Dra. en Bioquímica, INIBIOLP, Facultad de Cs. Médicas, Universidad Nacional de la Plata, La Plata, Argentina, Investigadora Independiente
2 Bioquímico, Inibiolp, Facultad de Ciencias Médicas, Universidad Nacional de la Plata.

Acceso a la fuente original
BBA Molecular and Cell Biology of Lipids
http://www.elsevier.com/wps/find/journaldescription.cws_home/506067/description

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