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Takeaki Nitto describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo ANTILEUKEMIA ACTIVITIES OF RETINOID AND ARSENIC All-trans retinoic acid and arsenic trioxide are recently recognized as effective agents to treat acute promyelocytic leukemia. These two agents reduce leukemia cells followed by affecting the function of the PML-RAR alpha, an unusual molecule as a result of the t(15;17) chromosomal translocation. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación Yokohama University of Pharmacy（横浜薬科大学）, Yokohama, Kanagawa, Japan  Authors' Report Crónica del Autor Bibliographic references Referencias bibliográficas 1. Lallemand-Breitenbach V, Jeanne M, Benhenda S, Nasr R, Lei M, Peres L, et al. Arsenic degrades PML or PML-RAR-alpha; through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol 10:547-555, 2008. 2. Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, et al. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA 101:5328-5335, 2004. 3. Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 369:111-121, 2013. 4. Ablain J, Rice K, Soilihi H, de Reynies A, Minucci S, De Thé H. Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure. Nat Med 20:167-174, 2014. SIIC System of Assisted Editing (SSEA) / Sistema SIIC de Edición Asistida (SSEA)
The article is strictly related to the following sections of siicsalud El artículo se relaciona estrictamente con las siguientes secciones de siicsalud
Information about the full text Acerca del trabajo completo Molecular Mechanisms of the Antileukemia Activities of Retinoid and Arsenic Author / Autor Takeaki Nitto1 1 Ph. D., Yokohama University Of Pharmacy（横浜薬科大学）, Yokohama, Japón, Professor Access to the original source Journal of Pharmacological Sciences Article URL: / URL del artículo: https://www.jstage.jst.go.jp/browse/jphs URL of Abstract: / URL del abstract: https://www.jstage.jst.go.jp/article/jphs/126/3/126_14R15CP/_article URL of Abstract page in Medline: / URL del abstract en Medline: http://www.ncbi.nlm.nih.gov/pubmed/25319615 siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |
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