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Vinod Gauttam describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo DEVELOPMENT OF PHOSPHOLIPID VESICLE ENTRAPPED POLYHERBAL ANTI-DIABETIC FORMULATION Several herbal extracts and phytoconstituents, despite having excellent bioactivity in vitro demonstrate less or no in vivo actions due to their poor lipid solubility. Phospholipids vesicles for the herbal preparations may produce better bioavailability and actions than the conventional phyto molecules or botanical extracts. In present study, we scientifically validated this hypothesis. Optimized combination (OC) of herbal extracts was encapsulated in phospholipids based vesicle system; this formulation at 500 mg/kg p.o. dose had shown significant antidiabetic effects in comparison to OC at 1 000 mg/kg p.o. in experimentally-induced diabetes. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación Indo-soviet Friendship College of Pharmacy, Moga, Punjab, India  Authors' Report Crónica del Autor Bibliographic references Referencias bibliográficas Baron AD. Postprandial hyperglycaemia and α-glucosidase inhibitors. Diab Res Clin Pract 40:S51-S5, 1998. Eurich DT, McAlister FA, Blackburn DF, Majumdar SR, Tsuyuki RT, Varney J, Johnson JA. Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review. BMJ 335:497-510, 2007. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and nitrate in biological fluids. Anal Biochem 126:31-38, 1982. Kakkar P, Das B, Viswanathan P. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophy 21:130-136, 1984. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nut 79:727-747, 2004. Niu M, Lu Y, Hovgaard L, Wu W. Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation. Int J Nanomedicine 6:1155-1167, 2011. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin and Exp Pharmacol and Phys 33:232-237, 2006. Rao V. Modern approaches to herbal medicine. East Pharmacist 12:35-38, 2000. Shaw JE, Sicreem RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87(1):4-14, 2010. Singleton VL, Orthofer R, Lamuela-Raventos RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Meth Enzymol 299:152-178, 1999. Tilburt JC, Kaptchuk TJ. Herbal medicine research and global health: an ethical analysis. Bull World Health Org 86:594-599, 2008. SIIC System of Assisted Editing (SSEA) / Sistema SIIC de Edición Asistida (SSEA)
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Information about the full text Acerca del trabajo completo Development of Polyherbal Antidiabetic Formulation Encapsulated in the Phospholipids Vesicle System Author / Autor Vinod Gauttam1, Ajudhia Nath Kalia2 2 Dr., I S F College of Pharmacy, Moga, Moga, India Access to the original source Journal of Advanced Pharmaceutical Technology and Research Article URL: / URL del artículo: URL of Abstract page in Medline: / URL del abstract en Medline: http://www.ncbi.nlm.nih.gov/pubmed/23833751 siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |
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