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AGENTES VIRAIS E A PREDISPOSIÇAO PARA DOENÇAS NEOPLASICAS E AUTOIMUNES

(especial para SIIC © Derechos reservados)
Autor:
Janaína luisa Leite
Columnista Experto de SIIC

Institución:
Universidade Estadual de Campinas

Artículos publicados por Janaína luisa Leite
Coautores
Natassia Elena Búfalo* Elaine Cristina Morari** Ana Carolina Trindade Guilhen* Roberto Bernardo Santos* Laura Sterian Ward*** 
Mestre - Pós-graduando, Universidade Estadual de Campinas, Campinas, Brasil*
Doutora - Pesquisadora, Universidade Estadual de Campinas, Campinas, Brasil**
Livre-Docente - Pesquisadora orientadora, Universidade Estadual de Campinas, Campinas, Brasil***
Recepción del artículo
14 de Mayo, 2008 		Aprobación
15 de Julio, 2008
Primera edición
26 de Marzo, 2009 		Segunda edición, ampliada y corregida
7 de Junio, 2021

AGENTES VIRAIS E A PREDISPOSIÇAO PARA DOENÇAS NEOPLASICAS E AUTOIMUNES

Resumen
Os herpesvírus têm sido vistos como potenciais agentes carcinogênicos e identificados em diversas malignidades. Acometem indivíduos imunossuprimidos e também indivíduos saudáveis e possuem elevada prevalência. A capacidade de permanecerem latentes nas células do hospedeiro garante aos vírus sua sobrevivência até serem reativados. Células infectadas por herpes supostamente não seriam destruídas por apoptose em portadores de alterações no gene TP53. Nossos estudos comprovam uma maior prevalência de herpesvírus tipo 6 em pacientes transplantados renais do que numa população controle e mostram que polimorfismos no gene TP53 poderiam influenciar na suscetibilidade à infecção por este vírus. Observamos que os herpesvírus também podem aumentar o risco para o desenvolvimento de carcinomas da pele e isso se associa ao perfil genotípico GSTM1-GSTT1+. Mais recentemente, estudando doenças auto-imunes, observamos que a infecção pelo herpesvírus 6 aumentou a susceptibilidade para o desenvolvimento da doença de Graves. Estes estudos poderão ter utilidade na prevenção de doenças. Por exemplo, pacientes em imunodepressão que tenham infecção por herpesvírus devem ser particularmente mais cuidadosos em relação à exposição solar.

Palabras clave
herpesvírus, câncer, transplantados, tiróide, doença de Graves


Artículo completo
(castellano)
Extensión:  +/-5.43 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

VIRAL AGENTS AND THEIR CORRELATION WITH THE GENETIC PROFILE OF PREDISPOSITION TO HUMAN NEOPLASTIC AND AUTOIMMUNE DISEASES

Abstract
Herpesviruses (HHV) are ubiquitous, have broad tissue tropism and have been found in the thyroid that can be a reservoir of latent HHV. HHV are considered potential carcinogenic agents and have been identified in many malignancies. More recently, they have also been associated to a series of autoimmune conditions. TP53 gene plays a critical role in cell cycle control, facilitating DNA repair activities and protecting against DNA damages. HHV infected cells may gain a dangerous survival time in individuals with impairing apoptotic ability such as the ones caused by TP53 gene polymorphisms. Other genes involved in the response to environmental aggressions, such as the genes that codify the Glutathione S-Transferase (GST) and other enzymatic protective systems, may modulate the risk to develop diseases. We recently demonstrated an increased risk for HHV6 infection in individuals that inherited a codon72TP53 polymorphism which reduces p53 apoptotic activity. Our studies demonstrated a higher prevalence of HHV type 6 in patients submitted to renal transplants than in a control population, suggesting that TP53 gene polymorphisms might affect the susceptibility to HHV infection. In addition, we observed that HHV can increase the risk of skin cancer development, an event associated with the Glutathione S-Transferase (GST) genotypic profile GSTM1-GSTT1+. More recently, investigating autoimmune diseases, we observed a high prevalence of HHV type 7, but not type 6 infection in Graves' disease patients. These individuals also presented the codon72TP53 germline polymorphism more frequently. Although further studies are needed, our results suggest that viral agents such as HHV may trigger autoimmune as well as neoplastic diseases in individuals with a genetic predisposing profile.

Key words
herpesvírus, cancer, predisposition, autoimmune diseases, genetic profile

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Oncología
Relacionadas: Anatomía Patológica, Bioquímica, Diagnóstico por Laboratorio, Endocrinología y Metabolismo, Genética Humana, Infectología, Inmunología, Medicina Interna



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Enviar correspondencia a:
Janaína Luisa Leite, Universidade Estadual de Campinas Faculdade de Ciências Médicas Laboratório de Genética Molecular do Câncer, 13083-970, Campinas, Brasil
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