Expertos Invitados





O PRURIGO ESTROFULO EM CRIANÇAS COM INFECÇAO PELO VIRUS DA IMUNODEFICIENCIA HUMANA E A ASSOCIAÇAO INVERSA COM GRAU DE IMUNOCOMPROMETIMENTO

(especial para SIIC © Derechos reservados)
As modificações imunológicas presentes em crianças infectadas pelo HIV nas fases de ausência de imunossupressão favorecem o desenvolvimento de hipersensibilidade à picada dos insetos.
oliveiradecarvalho.jpg Autor:
Vânia Oliveira de carvalho
Columnista Experto de SIIC

Institución:
Serviço de Dermatopediatria do Hospital de Clínicas da Universidade Federal do Paraná

Artículos publicados por Vânia Oliveira de carvalho
Coautores
Crisitna Rodrigues da Cruz* Hermênio Cavalcante Lima** 
Dra em Saúde da Criança e do Adolescente, Serviço de Dermatopediatria do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brasil*
Doutor em Imunologia Harvard University, Disciplina de Imunologia Clínica e Alergia do Departamento de Patologia Médica do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brasil**
Recepción del artículo
7 de Julio, 2006 		Aprobación
25 de Julio, 2006
Primera edición
27 de Octubre, 2007 		Segunda edición, ampliada y corregida
7 de Junio, 2021

O PRURIGO ESTROFULO EM CRIANÇAS COM INFECÇAO PELO VIRUS DA IMUNODEFICIENCIA HUMANA E A ASSOCIAÇAO INVERSA COM GRAU DE IMUNOCOMPROMETIMENTO

Resumen
Objetivo: Avaliar a prevalência do prurigo estrófulo em crianças infectadas pelo HIV e sua distribuição conforme as categorias imunológicas e a carga viral. Métodos: Estudo prospectivo, observacional de pacientes menores de 14 anos infectados pelo HIV que consultaram o Serviço de Infectologia Pediátrica do HC da UFPR. Uma avaliação foi realizada por Dermatopediatra e considerado caso de prurigo estrófulo o paciente com alergia a picadas de insetos e lesões clínicas compatíveis. A determinação dos valores de linfócitos T CD4+ e da carga viral foi feita no momento da consulta. Os pacientes foram estratificados nas categorias imunológicas. O estudo estatístico foi realizado com nível de significância de 5%. Resultados: Foram examinadas 127 crianças. Prurigo estrófulo foi observado em 33 pacientes, com média de 3 anos de idade e predominou nos meses quentes. Prurigo estrófulo foi mais prevalente nos pacientes com ausência de imunodeficiência. Porém, não houve diferença da média do número de cópias virais em pacientes com ou sem a dermatose. Conclusões: O prurigo estrófulo é observado em crianças infectadas pelo HIV na classificação imunológica "sem imunossupressão". Estes achados sugerem que modificações imunológicas, promovidas pelo HIV em algumas fases da doença, podem favorecer o desenvolvimento de hipersensibilidade à picada dos insetos.

Palabras clave
Prurigo, AIDS, HIV, imunossupressão, hipersensibilidade


Artículo completo
(castellano)
Extensión:  +/-6.61 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

PAPULAR URTICARIA IN CHILDREN WITH HIV INFECTION AND ITS INVERSE ASSOCIATION WITH IMMUNOCOMPROMISSED DEGREE

Abstract
Objective: To evaluate the prevalence of prurigo strophulus in HIV infected children and whether its distribution conforms to immunological categories and viral load. Methods: Prospective observational study in HIV infected children under 14 year olds who were seen at the Pediatric Infectology Service, UFPR University Hospital. An evaluation was performed by pediatric dermatology specialists who considered prurigo strophulus as an allergy to insect bites and compatible clinical lesions. CD4+ T lymphocyte count and viral load were determined at consultation time. Patients were stratified by immunological category. Statistical analysis was performed with a 5% significance level. Results: Prurigo strophulus was seen in 33 of 127 children, at a mean age of 3 years, with predominance in warmer months and in patients without immunodeficiency. There was no difference in mean number of viral copies between patients with or without the dermatosis. Conclusions: Prurigo strophulus is seen in HIV infected children immunoclassified as without immunosuppression. These findings suggest that immunological changes promoted by HIV in some phases of the disease could help hypersensitivity to insect bites develop.

Key words
Prurigo, AIDS, HIV, imunossupression, hipersensibility

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Infectología
Relacionadas: Bioquímica, Dermatología, Diagnóstico por Laboratorio, Medicina Interna, Pediatría



Comprar este artículo
Extensión: 6.61 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra



Enviar correspondencia a:
Vânia Oliveira de Carvalho, Serviço de Dermatopediatria do Hospital de Clínicas da Universidade Federal do Paraná, 80 820-110, Rua Richard Strauss 62 Vista Alegre, Curitiba, Brasil
Bibliografía del artículo
1. Novelli VM. Assessing prognosis in infants infected with human immunodeficiency virus. J Pediatr 1996; 129(5):623-5.
2. Uthayakumar S, Nandwani R, Drinkwater T, Nayagam AT, Darley CR. The prevalence of skin disease in HIV infection and its relationship to the degree of immunosuppression. Br J Dermatol 1997; 137(4):595-8.
3. Lim W, Sadick N, Gupta A, Kaplan M, Pahwa S. Skin diseases in children with HIV infection and their association with degree of immunosuppression. Int J Dermatol 1990; 29(1):24-30.
4. King MD, Reznik DA, O'Daniels CM, Larsen NM, Osterholt D, Blumberg HM. Human papillomavirus-associated oral warts among human immunodeficiency virus-seropositive patients in the era of highly active antiretroviral therapy: an emerging infection. Clin Infect Dis 2002; 34(5):641-8.
5. El Hachem M, Bernardi S, Pianosi G, Krzysztofiak A, Livadiotti S, Gattinara GC. Mucocutaneous manifestations in children with HIV infection and AIDS. Pediatr Dermatol 1998; 15(6):429-34.
6. Lèauté-Labréze C, Niamba P, Douard D, Taïeb A. Cutaneous manifestations of paediatric HIV infection: a cohort study of 35 patients. Ann Dermatol Veneorol 1998; 125(S1P2):80.
7. Wiznia AA, Lambert G, Pavlakis S. Pediatric HIV infection. Med Clin North Am 1996; 80(6):1309-36.
8. Clerici M, Fusi ML, Ruzzante S, Piconi S, Biasin M, Arienti D, et al. Type 1 and type 2 cytokines in HIV infection - a possible role in apoptosis and disease progression. Ann Med 1997; 29(3):185-8.
9. Secord EA, Kleiner GI, Auci DL, Smith-Norowitz T, Chice S, Finkielstein A, et al. IgE against HIV proteins in clinically healthy children with HIV disease. J Allergy Clin Immunol 1996; 98(5 Pt 1):979-84.
10. Forsea D, Madarescu M, Strauss L, Petrea S, Tiplica S, Popescu C, Lacobescu R. Cutaneous manifestations in AIDS children. Ann Dermatol Veneorol 1998; 125(S1P3):80-1.
11. Orozco Y, Cafe E. Skin manifestations in children HIV positive update. Ann Dermatol Venereol 2002; 129(1S):813.
12. Ministério da Saúde. Brasil. Programa Nacional de DST e Aids. Guia de tratamento clinico da infecção pelo HIV em crianças. Secretaria de Vigilância em Saúde. 2004.
13. Centers for disease Control. Revised classification system for human immunodeficiency virus infection in children less Than 13 years of age. MMWR 1994; 43 (RR-12):1-19.
14. Martins ER, Ourici A, Chigros B. Prurigo estrófulo. Alerg Pediatr 1989; 3:5-8.
15. Stibich AS, Schartz RA. Papular urticaria. Cutis 2001; 68(2):89-91.
16. Maunder JW. In: Harper J, Orange A, Prose N. Text book of pediatric dermatology. 1 ed. United Kingdom: Blackwell Science; 2000.
17. Pradinaud R, Sainte-Marie D, Strobel M, Degarve B, Roul S. Le prurigo en milieu tropical. Importance de son association avec l'infection a VIH. Bull Soc Pathol Exot 1993; 86(5 Pt 2):512-6.
18. Protonotariou E, Malamitsi-Puchner A, Rizos D, Sarandakou A, Makrakis E, Salamolekis E. Alterations in Thl/Th2 cytokine concentrations in early neonatal life. J Matern Fetal Neonatal Med 2003; 14(6):407-10.
19. Rich RR, Fleisher TT, Shearer WT, Kotizn BL, Schroeder HW, Jr. Clinical immunology principles and practice 2nd ed. New York: C.V. Mosby; 2001.
20. Mahe A, Cisse I, Faye O, N'Diaye HT, Niamba P. Skin diseases in Bamako (Mali). Int J Dermatol 1998; 37(9):673-6.
21. Carvalho VO, Flenick LTM, Taniguchi K, Marinoni LP, Giraldi S, Bertogna J. Alterações dermatológicas em crianças com AIDS e sua relação com categorias clínico-imunológicas e carga viral. An Bras Dermatol 2003; 78(6):679-92.
22. El Hachem M, Tudor G, Matusa R, Pascu R, Borguese L, Cristini S, Castelli I, Gattinara G. Mucocutaneous infections in romanian HIV infected children: medical and surgical treatment of 400 cases. Ann Dermatol Veneorol 1998; 125(S1P4):81.
23. Rangel GV, Rubini NPM, Leal DWC, Cordovil AVDP, Arabe J, Capelo, AV. Manifestações mucocutâneas na AIDS pediátrica. Programa oficial do VII Congresso Brasileiro de Alergia e Imunologia em Pediatria; 1999; Brasília, Brasil; 1999. p. 123.
24. Garcia E, Halpert E, Rodriguez A, Andrade R, Fiorentino S, Garcia C. Immune and histopathologic examination of flea bite-induced papular urticaria. Ann Allergy Asthma Immunol 2004; 92(4):446-52.
25. Shibasaki M, Sumazaki R, Takita H. Hypersensitive reactions to mosquito bites in congenital agammaglobulinemia. Ann Allergy 1986; 56(1):81-4.
26. Clerici M, Shearer GM. The Th1-Th2 hypothesis of HIV infection: new insights. Immunol Today 1994; 15(12):575-81.
27. Becker Y. The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers-a review and hypothesis. Virus Genes 2004; 28(1):5-18.
28. Corominas M, García JF, Mestre M, Fernández Viladrich P, Buendía E. Predictors of atopy in HIV-infected patients. Ann Allergy Asthma Immunol 2000; 84(6):607-11.
29. Romagnani S, Maggi E. Th1 versus Th2 responses in AIDS. Curr Opin Immunol 1994; 6(4):616-22.
30. Lyamuya EF, Matee MI, Kasubi M, Scheutz F. Immunoglobulin profile in HIV-1 infected children in Dar es Salaam. East Afr Med J 1999; 76(7):370-5.
31. Seroogy CM, Wara DW, Bluth MH, Dorenbaum A, White C, Durkin HG, et al. Cytokine profile of a long-term pediatric HIV survivor with hyper-IgE syndrome and a normal CD4 T-cell count. J Allergy Clin Immunol 1999; 104(5):1045-51.
32. Douek DC, Koup RA, McFarland RD, Sullivan JL, Luzuriaga K. Effect of HIV on thymic function before and after antiretroviral therapy in children. J Infect Dis 2000; 181(4):1479-82.
33. Feeney ME, Draenert R, Roosevelt KA, Pelton SI, McIntosh K, Burchett SK, et al. Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection. J Immunol 2003; 171(12):6968-75.
34. Roberts G, Peckitt C, Northstone K, Strachan D, Lack G, Henderson J, et al. Relationship between aeroallergen and food allergen sensitization in childhood. Clin Exp Allergy 2005; 35(7):933-40.
35. Tangsinmankong N, Kamchaisatian W, Lujan-Zilbermann J, Brown CL, Sleasman JW, Emmanuel PJ. Varicella zoster as a manifestation of immune restoration disease in HIV-infected children. J Allergy Clin Immunol 2004; 113(4):742-6.
36. Diven DG, Newton RC, Ramsey KM. Heightened cutaneous reactions to mosquito bites in patients with acquired immunodeficiency syndrome receiving zidovudine. Arch Intern Med 1988; 148(10):2296.
37. Sempowski GD, Hicks CB, Eron JJ, Bartlett JA, Hale LP, Ferrari G, et al. Naive T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: Implications for analysis of thymus function. J Clin Immunol 2005; 25(5):462-72.
38. Sundharam JA. Pruritic skin eruption in the acquired immunodeficiency syndrome: arthropod bites? Arch Dermatol 1990; 126(4):539.
39. Resneck JS, Jr., Van Beek M, Furmanski L, Oyugi J, LeBoit PE, Katabira E, et al. Etiology of pruritic papular eruption with HIV infection in Uganda. JAMA 2004; 292(21):2614-21.
40. Rosatelli JB, Machado AA, Roselino AM. Dermatoses among Brazilian HIV-positive patients: correlation with the evolutionary phases of AIDS. Int J Dermatol 1997; 36(10):729-34.
41. Liautaud B, Pape JW, DeHovitz JA, Thomas F, LaRoche AC, Verdier RI, et al. Pruritic skin lesions. A common initial presentation of acquired immunodeficiency syndrome. Arch Dermatol 1989; 125(5):629-32.
42. Muhammad B, Eligius L, Mugusi F, Aris E, Chale S, Magao P, et al. The prevalence and pattern of skin diseases in relation to CD4 counts among HIV-infected police officers in Dar es Salaam. Trop Doct 2003; 33(1):44-8.
43. Aires JM, Rosatelli JB, de Castro Figueiredo JF, Roselino AM. Cytokines in the pruritic papular eruption of HIV. Int J Dermatol 2000; 39(12):903-6.
44. Wananukul S, Thisyakorn U. Mucocutaneous manifestations of HIV infection in 91 children born to HIV-seropositive women. Pediatr Dermatol 1999; 16(5):359-63.
45. Wananukul S, Deekajorndech T, Panchareon C, Thisyakorn U. Mucocutaneous findings in pediatric AIDS related to degree of immunosuppression. Pediatr Dermatol 2003; 20(4):289-94.
 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
ua31618
Home

Copyright siicsalud © 1997-2024 ISSN siicsalud: 1667-9008