FARMACOLOGIA E POSSIVEIS INDICAÇOES CLINICAS DA VASOPRESSINA. UMA REVISAO SOBRE UMA ANTIGA E ATUAL DROGA

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Apesar de todas as evidências favoráveis da vasopresina, a ausência de dados relacionados a possíveis efeitos colaterais, limita o seu uso em humanos.
barbosaevora9.jpg Autor:
Paulo r. Barbosa evora
Columnista Experto de SIIC

Institución:
Laboratório de Função Cardiovascular e Endotelial da Divisão de Cirurgia Experimental da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo


Artículos publicados por Paulo r. Barbosa evora
Coautores
Alfredo José Rodrigues* Eduardo Guilherme Leite** 
Professor Doutor, Universidade de São Paulo, Ribeirão Preto, Brasil*
Estudante de Medicina, Universidade de São Paulo, Ribeirão Preto, Brasil**
Recepción del artículo
25 de Enero, 2006
Aprobación
24 de Febrero, 2006
Primera edición
11 de Julio, 2006
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
A vasopressina, ou hormônio anti-diurético, é um hormônio peptídeo que é sintetizado nos núcleos supraórticos e paraventriculares do hipotálamo e transportado para a hipófise posterior, onde é armazenado. É liberado na circulação por estímulo da osmolalidade aumentada do protoplasma ou como uma resposta baroreflexa a diminuições do volume ou pressões sanguíneos. 1) A liberação de vasopressina é aumentada também por náusea, dor, e outros estímulos. Apesar de ser uma antiga droga a vasopressina tem sido de modo crescente na literatura médica, principalmente relacionando os seus possíveis efeitos terapêuticos na ressuscitação cardiopulmonar e choque circulatório vasoplégico. Esse fato motivou a presente revisão subdividida em itens: 1) Aspectos gerais; 2) Efeitos na circulação coronariana; 3) Efeitos na circulação pulmonar; 4) Efeitos na parada cardíaca; 5) Efeitos na circulação cerebral e morte eencefálica; 6) Utilização terapêutica no choque circulatório e; 7) Utilização terapêutica em cirurgia cardíaca. A vasopressina é um agente pressórico não adrenérgico com significante efeito vasoconstritor, o qual pode ser utilizado, clinicamente, em situações de choque vasoplégico e ressuscitação cardiorespiratória irreversível pelas manobras clássicas. Apesar de todas as evidências favoráveis mencionadas, a ausência de dados relacionados a possíveis efeitos colaterais, limita o seu uso em humanos.

Palabras clave
vasopressina, hormônio anti-diurético


Artículo completo

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Abstract
Vasopressin is a peptide hormone that is synthesized in the hypothalamus supraoptic and paraventricular nuclei and transported to the posterior pituitary, where it is stored. It is released into the circulation upon stimulation by increased plasma osmolality or as a baroreflex response to decreases in blood volume or blood pressure. Vasopressin release is also increased by nausea, pain, and other stimuli. The recent medical literature reports its therapeutic effects in cardiopulmonary arrest and vasoplegic circulatory shock. This fact motivated the present review organized in the following items: 1) General aspects; 2) Coronary circulation effects; 3) Lung circulation effects; 4) Cardiac arrest; 5) Effects in the cerebral circulation and encephalic death; 6) Therapeutic use in circulatory shock and; 7) Therapeutic use in heart surgery. Vasopressin is a non adrenergic pressoric agent with significant vasoconstritor effect, which can be clinically used in situations of vasoplegic shock and cardiopulmonary resuscitation irreversible by the classic maneuvers. In spite of all this favorable evidences, the absence of data related to possible side effects, limits its use in humans.

Key words
vasopressin, antidiuretic hormone


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Farmacología
Relacionadas: Medicina Farmacéutica, Medicina Interna, Nefrología y Medio Interno



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Enviar correspondencia a:
Paulo Robe Barbosa Evora, Laboratório de Função Cardiovascular e Endotelial da Divisão de Cirurgia Experimental da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, 14105-120, Rua Rui Barbosa 367, Ap. 15, Ribeirão Preto, Brasil
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