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METILACION DEL GEN ER EN EL CARCINOMA ENDOMETRIAL

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La metilación del gen del receptor estrogénico (ER) cumpliría un papel en la regulación de la trascripción ER en el carcinoma endometrial.
shiozawa9.jpg Autor:
t Shiozawa
Columnista Experto de SIIC
Artículos publicados por t Shiozawa
Coautor
Ikuo Konishi.* 
M.D., Ph. D Department of Obstetrics and Gynecology, Shinshu University School of Medicine*
Recepción del artículo
26 de Enero, 2004 		Primera edición
7 de Mayo, 2004 		Segunda edición, ampliada y corregida
7 de Junio, 2021

METILACION DEL GEN ER EN EL CARCINOMA ENDOMETRIAL

Resumen
Recientes investigaciones revelaron que la metilación CpGs de varios genes se encuentra profundamente involucrada en la regulación de la trascripción. La regulación de la expresión del receptor estrogénico (ER) es un ejemplo representativo del silenciamiento génico mediado por la metilación. Este artículo revisa los patrones de expresión y el papel del ER en los tejidos endometriales y la posible responsabilidad de la metilación del gen ER en la regulación de la trascripción del ER en el carcinoma endometrial.

Palabras clave
Endometrio, carcinoma endometrial, receptor estrogénico, isla CpG, metilación, cambios epigenéticos


Artículo completo
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Extensión:  +/-9.72 páginas impresas en papel A4
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ESTROGEN RECEPTOR EXPRESSION AND GENE METHYLATION IN ENDOMETRIAL CARCINOMA

Abstract
Recent researches have revealed that the methylation CpGs of various genes is deeply involved in the transcription regulation. The regulation of estrogen receptor (ER) expression is a representative example of methylation-mediated gene silencing. This article reviews the expression pattern and its roles of ER in endometrial tissues, and possible involvement of ER gene methylation in ER transcription regulation in endometrial carcinoma.

Key words
Endometrium, endometrial carcinoma, estrogen receptor, CpG island, methylation, epigenetic change


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Especialidades
Principal: Oncología
Relacionadas: Bioquímica, Obstetricia y Ginecología



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Bibliografía del artículo
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