Figura 4. Tumor fibroso solitario de pleura. a) H&E, b) CD34 7É3 (CUADRO 1, A DOS COLUMNAS) (TITULO)Cuadro 1. Células que normalmente expresan CD-34. (COLUMNA 1) Células precursoras en médula ósea (células madre) Linfocitos de la zona marginal esplénica Células en las Placas de Peyer Endotelio vascular Endotelio linfático Células dendríticas intersticiales Células del miometrio Células del endoneurio (no células de Schwann) (COLUMNA 2)Referencia 11116,2815,16163319 (CUADRO 2, A TRES COLUMNAS) (TITULO)Cuadro 2. Neoplasias que expresan CD-34. (COLUMNA 1) Neoplasia Leucemia linfoblástica aguda Leucemia mieloblástica aguda Sarcoma granulocítico Angiosarcoma Sarcoma de Kaposi Hemangioendotelioma epitelioide Linfangiomas Tumores gastrointestinales del estroma Tumores epitelioides de músculo liso Neurofibromas Schwannomas Hemangiopericitoma Sarcoma epitelioide Tumor fibroso solitario Dermatofibrosarcoma Protuberans Dermatofibrosarcoma pigmentado (Tumor de Brednar) Elastofibroma Positividad en casos aislados Sarcoma de células claras Carcinoma epidermoide pulmonar 7É3 Adenocarcinoma endometrial Meningioma Fibrohistiocitoma maligno (COLUMNA 2)% de positividad 50% 40%75%70% 93%100%33% 82% 63% 82% 100%66% 56% 81% 96% 96% 100% (COLUMNA 3)Referencia 10,20,21,26,294,10,11,26,2929281,3,14,16,28,313,14,15,2829,33-35291,191,193,14,28,2937,4035,36-3829,3929,394111111Bibliografía 1. Van de Rijn M, Rouse RV. «CD-34 A review», Appl Immunohistochem , 2:71-80, 1994.2. Civin CI, Strauss LC, Brovall C, Fackler MJ. Schwartz JF, 7É3 Shaper JH. «Antigenic analysis of hematopoyesis. III. A hematopoyetic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells», J Inmmunol , 133:157-167, 1984.3. Kraise DS, Fackler MJ, Civin CI, May S. «CD34: Structure, biology and clinical utility», Blood , 87:1-13, 1996.4. Molgaard HV, Spurr NK, Greaves MF. «The hematopoyetic stem cell antigen, CD-34 is encoded by a gene located on chromosome 1», Leukemia , 3:773-776, 1989.5. Fackler MJ, Civin CI, May WS. «Up-regulation of surface CD-34 is associated with protein kinase C-mediated hyperphosphorilation of CD-34», J Biol Chem , 267:17540-17546, 1992.6. Baumhueter S, Singer MS, Henzel W, et al. «Binding of L-selectin to the vascular sialomucin CD34», Science , 262:436-438, 1993.7. Girard J-P, Springer TA. «High endothelial venules (HEVs): specialized endothelium for lymphocyte migration», Imm Today , 16:449-457, 1995. 8. Krause DS, Ito T, Fackler M, Collector M, Sharkis S, May W. «Characterization of murine CD34, a marker of hematopoyetic progenitor stem cells», Blood , 84:691-701, 1994.9. Blumcke I, Gienke K, Wardelman E y col. «The Cd34 epitope is expresed in neoplastic and malformative lesions associated with chronic, focal epilepsies», Acta Neuropathol (Berl) , 5:481-490, 1999.10. Breschorner WE. Civin CI, Strauss LC. «Localization of the hematopoyetic progenitor cells in tissue with anti-My-10 monoclonal antibody», Am J Pathol , 119:1-4, 1985.11. Orazi A, Neiman RS, Cualing H Heereman NA, John K. «CD34 immunostaining of bone marrow biopsy specimen is a reliable way to classify the phase of chronic myeloid leukemia», Am J Clin Pathol , 101:426-428, 1994.12. Ortiz Hidalgo C, Reynoso G. «Angiogenesis tumoral», Patología (Mex) , 32:43-48, 1994.13. Ikeda A, Adachi M, Taki T y col. «Prognostic significance of angiogenesis in human panceratic cacner», Br J cancer , 79: 1553-1563, 1999.14. Kuzu Y, Bicknell R, Harris AL, Jones M, Gatter K, Masson DY. «Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumors», J Clin Path , 45:143-148, 1992.15. Ramani P, Shah A. «Lymphangiomatosis. Histologic and immunohistochemical analysis of four cases», Am J Surg Pathol , 17:329-235, 1993.16. Nickoloff BJ. «The human progenitor cell antigen (CD-34) is localized on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferating endothelial cells and stromal spindle-shape cells in Kaposi\'s sarcoma», Arch dermatol , 127:523-529, 1991.17. Sueki H, Whitaker D, Buchsbaum , Murphy GF. «Novel interactions between dermal dendrocytes and mast cells in human skin: Implications for hemostasis and matrix repair», Lab Invest , 69:160-172, 1993.18. Nakayama H, Naruse K, Myyazaki Et col. «The specific distribution of dendritic intestitial cels at the tumor border of major salivary gland pleomorphic adenoma», Mod Pathol , 7É3 12:445-449, 1999.19. Weiss SW, Nickoloff BJ. «CD-34 is expressed by a distinct cell population in peripheral nerve, nerve sheath tumors and related lesions», Am J Surg Pathol , 17:1039-1045, 1993.20. Borowits MJ, Shuster JJ, Civin CI, et al. «Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: A pediatric oncology group study», 8:1386-1398, 1990.21. Borowits MJ, Gockerman JP, Moore Jo, et al. «Clinicopathologic and cytogenetic features of CD34 (My10) positive acute nonlymphocytic leukemia», Am J Clin Pathol , 91:265-270, 1989.22. Indolfi P, Casale F, Farzati B, D\'Angelo V, De Sangro C, Rinaldi B. «Prognostic irrelevance of CD34 epression in childhood B-precursor acute lymphoblastic leukemia», Hematologica , 84: 567-568, 1999.23. Hurwitz C, Raimondi S, Head D, et al. «Distinct immunophenotypic features of at (8; 21) (q22; q22) acute myeloblastic leukemia in children», Blood , 80:3182-3188, 1992.24. Geller RB, Zahurak M, Hurwitz CA, et al. «Prognostic importance of immunotyping in adults with acute myelocytic leukaemia: The significance of stem-cell glycoprotein CD34 (My10)», Br J Haematol , 76:340-345, 1990,25. Guyotat D, Campos L. Thomas Z. Et al. «Myelodysplasic syndromes. A study of surface markers and in-vitro growth patterns», Am J Hematol , 34:26-31, 1990.26. Soligo D, Delia D, Oriani A et al. «Identification of CD-34 + cells in normal en pathologic bone marrow biopsies by QBEND710 monoclonal antibody», Leukemia , 15:1026-1030, 1991.27. Traweek ST, Arber DA, Rapapport H, Brynes RK. «Extramedullary myeloid cells tumors: an immunohistochemical and morphologic study of 28 cases», Am J Surg Pathol , 17:1011-1019, 1993.28. Traweek ST, Kandalaft PL, Mehta P, Battifora H. «The human hematopoyetic progenitor cell antigen (CD-34) in vascular neoplasia», Am J Pathol , 96:25-31, 1991.29. Aziza J, Mazerolles C, Selves J et al. «Comparison of the reactivities of monoclonal antibodies QBEND/10 (CD34) and BNH9 in vascular tumors», Appl Immunohistochem , 1:51-57, 1993.30. Sankey EA. More L, Dhillon AP. «QBEnd/10: a new immunostain for the routine diagnosis of Kaposi\'s sarcoma», J Pathol , 161:267-271, 1990.31. Renshaw AA, Paulus W, Joseph JT. «CD34 and epithelial membrane antigen distinguish dural hemangiopericytoma and meningioma», Appl, Immunohistochem , 3:108-114, 1995.32. Sánchez Pacheco A, de León Bojorge B, Ylgovsky L, Ortiz-Hidalgo C. «Hemangiopericitoma meningeo, Estucio inmunohistoquímico y ultraestrctural», Arch neurocien (Mex) , 3:225-228, 1998.33. van de Rijn M, Hendrickson MR, Rouse RV. «CD34 expression by gastrointestinal tract stromal tumors», Hum Pathol , 25:766-771, 1994.34. Rumessen JJ, Peters S, Thuneberg L. «Light -and electron microscopical studies of interstitial cells of Cajal and muscle cells at the submucosal border of human colon», Lab Invest , 1:51-57, 1993. 7É3 35. Chan JKC. «Mesenchymal tumors of the gastrointestinal tract: A paradise for acronims (STUMP, GIST, GANT andnow GIPACT), Implications of c.kiy in genesis, adn yet another of the many emerging roles of the interstitial cell of Cajal in the pathogenesis of gastrointestinal disease», Adv Anat Pathol , 6:19-40, 1999.36. Renshaw AA, Pinkus GS, Corson JM. «CD34 and AE1/AE3. Diagnostic discriminants in the distinction of solitary fibrous tumor of the pleura from sarcomatoid mesothelioma», Appl Immunohistochem , 2:94-102, 1994.37. Fletcher CDM. «Soft tissue tumours: an up-date. Recent Advances in Histopathology», Anthony PP, MacSween RNM , 15 Ed, pp 113-140, 1992.38. Ortiz-Hidalgo C, Baquera-Heredia J, Rojas-Reyna G, Craig R. «Solitary fobfous tumor of the carotid bifurcation clinically simulating a chemodectoma», Int J Surg Pathol , 6:223-228, 1998.39. Kutzner H. «Expression of the human progenitor cell antigen CD34 (HPCA-1) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalin-fixed, paraffin embedded tissue», J Am Acad Dermatol , 28:613-617, 1993.40. Haycox CL, Odland PB, Olbricht SM, Piepkorn M. «Immunohistochemical characterization of dermatofibrosarcoma protuberans with practical applications for diagnosis and treatment», JK Am Acad Dermatol , 37:438-444, 1997.41. Ruelas-Villaviciencio AL, Aponte Paredes PS, Ortiz-Hidalgo C. «Expresión de CD34 en el elastofibroma. Estudio clinicopatológico e inmunohistoquímico de 4 casos», Rev Invest Clin , 51:11-16, 1999.42. Scott FR, Rafaie A.El, More L, Scheuer PJ, Dhillon AP. «Hepatocellular carcinoma arising in an adenoma: value of QBend 10 immunostaining in diagnosis of liver cell carcinoma», Histopathology , 28:472-474, 1996.43. Zimmerman TM, Williams SF. Cytokines Cell Mol Ther, 4:257-264, 1998.Figura 3. Tumor del estroma del estómago. a) H&E, b) CD34, c) CD117(ckit). (Sistema ABC / diaminobencidina) Figura 4. Tumor fibroso solitario de pleura. a) H&E, b) CD34 7É3 (CUADRO 1, A DOS COLUMNAS) (TITULO)Cuadro 1. Células que normalmente expresan CD-34. (COLUMNA 1) Células precursoras en médula ósea (células madre) Linfocitos de la zona marginal esplénica Células en las Placas de Peyer Endotelio vascular Endotelio linfático Células dendríticas intersticiales Células del miometrio Células del endoneurio (no células de Schwann) (COLUMNA 2)Referencia 11116,2815,16163319 (CUADRO 2, A TRES COLUMNAS) (TITULO)Cuadro 2. Neoplasias que expresan CD-34. (COLUMNA 1) Neoplasia Leucemia linfoblástica aguda Leucemia mieloblástica aguda Sarcoma granulocítico Angiosarcoma Sarcoma de Kaposi Hemangioendotelioma epitelioide Linfangiomas Tumores gastrointestinales del estroma Tumores epitelioides de músculo liso Neurofibromas Schwannomas Hemangiopericitoma Sarcoma epitelioide Tumor fibroso solitario Dermatofibrosarcoma Protuberans Dermatofibrosarcoma pigmentado (Tumor de Brednar) Elastofibroma Positividad en casos aislados Sarcoma de células claras Carcinoma epidermoide pulmonar 7É3 Adenocarcinoma endometrial Meningioma Fibrohistiocitoma maligno (COLUMNA 2)% de positividad 50% 40%75%70% 93%100%33% 82% 63% 82% 100%66% 56% 81% 96% 96% 100% (COLUMNA 3)Referencia 10,20,21,26,294,10,11,26,2929281,3,14,16,28,313,14,15,2829,33-35291,191,193,14,28,2937,4035,36-3829,3929,394111111Bibliografía 1. Van de Rijn M, Rouse RV. «CD-34 A review», Appl Immunohistochem , 2:71-80, 1994.2. Civin CI, Strauss LC, Brovall C, Fackler MJ. Schwartz JF, 7É3 Shaper JH. «Antigenic analysis of hematopoyesis. III. A hematopoyetic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells», J Inmmunol , 133:157-167, 1984.3. Kraise DS, Fackler MJ, Civin CI, May S. «CD34: Structure, biology and clinical utility», Blood , 87:1-13, 1996.4. Molgaard HV, Spurr NK, Greaves MF. «The hematopoyetic stem cell antigen, CD-34 is encoded by a gene located on chromosome 1», Leukemia , 3:773-776, 1989.5. Fackler MJ, Civin CI, May WS. «Up-regulation of surface CD-34 is associated with protein kinase C-mediated hyperphosphorilation of CD-34», J Biol Chem , 267:17540-17546, 1992.6. Baumhueter S, Singer MS, Henzel W, et al. «Binding of L-selectin to the vascular sialomucin CD34», Science , 262:436-438, 1993.7. Girard J-P, Springer TA. «High endothelial venules (HEVs): specialized endothelium for lymphocyte migration», Imm Today , 16:449-457, 1995. 8. Krause DS, Ito T, Fackler M, Collector M, Sharkis S, May W. «Characterization of murine CD34, a marker of hematopoyetic progenitor stem cells», Blood , 84:691-701, 1994.9. Blumcke I, Gienke K, Wardelman E y col. «The Cd34 epitope is expresed in neoplastic and malformative lesions associated with chronic, focal epilepsies», Acta Neuropathol (Berl) , 5:481-490, 1999.10. Breschorner WE. Civin CI, Strauss LC. «Localization of the hematopoyetic progenitor cells in tissue with anti-My-10 monoclonal antibody», Am J Pathol , 119:1-4, 1985.11. Orazi A, Neiman RS, Cualing H Heereman NA, John K. «CD34 immunostaining of bone marrow biopsy specimen is a reliable way to classify the phase of chronic myeloid leukemia», Am J Clin Pathol , 101:426-428, 1994.12. Ortiz Hidalgo C, Reynoso G. «Angiogenesis tumoral», Patología (Mex) , 32:43-48, 1994.13. Ikeda A, Adachi M, Taki T y col. «Prognostic significance of angiogenesis in human panceratic cacner», Br J cancer , 79: 1553-1563, 1999.14. Kuzu Y, Bicknell R, Harris AL, Jones M, Gatter K, Masson DY. «Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumors», J Clin Path , 45:143-148, 1992.15. Ramani P, Shah A. «Lymphangiomatosis. Histologic and immunohistochemical analysis of four cases», Am J Surg Pathol , 17:329-235, 1993.16. Nickoloff BJ. «The human progenitor cell antigen (CD-34) is localized on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferating endothelial cells and stromal spindle-shape cells in Kaposi\'s sarcoma», Arch dermatol , 127:523-529, 1991.17. Sueki H, Whitaker D, Buchsbaum , Murphy GF. «Novel interactions between dermal dendrocytes and mast cells in human skin: Implications for hemostasis and matrix repair», Lab Invest , 69:160-172, 1993.18. Nakayama H, Naruse K, Myyazaki Et col. «The specific distribution of dendritic intestitial cels at the tumor border of major salivary gland pleomorphic adenoma», Mod Pathol , 7É3 12:445-449, 1999.19. Weiss SW, Nickoloff BJ. «CD-34 is expressed by a distinct cell population in peripheral nerve, nerve sheath tumors and related lesions», Am J Surg Pathol , 17:1039-1045, 1993.20. Borowits MJ, Shuster JJ, Civin CI, et al. «Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: A pediatric oncology group study», 8:1386-1398, 1990.21. Borowits MJ, Gockerman JP, Moore Jo, et al. «Clinicopathologic and cytogenetic features of CD34 (My10) positive acute nonlymphocytic leukemia», Am J Clin Pathol , 91:265-270, 1989.22. Indolfi P, Casale F, Farzati B, D\'Angelo V, De Sangro C, Rinaldi B. «Prognostic irrelevance of CD34 epression in childhood B-precursor acute lymphoblastic leukemia», Hematologica , 84: 567-568, 1999.23. Hurwitz C, Raimondi S, Head D, et al. «Distinct immunophenotypic features of at (8; 21) (q22; q22) acute myeloblastic leukemia in children», Blood , 80:3182-3188, 1992.24. Geller RB, Zahurak M, Hurwitz CA, et al. «Prognostic importance of immunotyping in adults with acute myelocytic leukaemia: The significance of stem-cell glycoprotein CD34 (My10)», Br J Haematol , 76:340-345, 1990,25. Guyotat D, Campos L. Thomas Z. Et al. «Myelodysplasic syndromes. A study of surface markers and in-vitro growth patterns», Am J Hematol , 34:26-31, 1990.26. Soligo D, Delia D, Oriani A et al. «Identification of CD-34 + cells in normal en pathologic bone marrow biopsies by QBEND710 monoclonal antibody», Leukemia , 15:1026-1030, 1991.27. Traweek ST, Arber DA, Rapapport H, Brynes RK. «Extramedullary myeloid cells tumors: an immunohistochemical and morphologic study of 28 cases», Am J Surg Pathol , 17:1011-1019, 1993.28. Traweek ST, Kandalaft PL, Mehta P, Battifora H. «The human hematopoyetic progenitor cell antigen (CD-34) in vascular neoplasia», Am J Pathol , 96:25-31, 1991.29. Aziza J, Mazerolles C, Selves J et al. «Comparison of the reactivities of monoclonal antibodies QBEND/10 (CD34) and BNH9 in vascular tumors», Appl Immunohistochem , 1:51-57, 1993.30. Sankey EA. More L, Dhillon AP. «QBEnd/10: a new immunostain for the routine diagnosis of Kaposi\'s sarcoma», J Pathol , 161:267-271, 1990.31. Renshaw AA, Paulus W, Joseph JT. «CD34 and epithelial membrane antigen distinguish dural hemangiopericytoma and meningioma», Appl, Immunohistochem , 3:108-114, 1995.32. Sánchez Pacheco A, de León Bojorge B, Ylgovsky L, Ortiz-Hidalgo C. «Hemangiopericitoma meningeo, Estucio inmunohistoquímico y ultraestrctural», Arch neurocien (Mex) , 3:225-228, 1998.33. van de Rijn M, Hendrickson MR, Rouse RV. «CD34 expression by gastrointestinal tract stromal tumors», Hum Pathol , 25:766-771, 1994.34. Rumessen JJ, Peters S, Thuneberg L. «Light -and electron microscopical studies of interstitial cells of Cajal and muscle cells at the submucosal border of human colon», Lab Invest , 1:51-57, 1993. 7É3 35. Chan JKC. «Mesenchymal tumors of the gastrointestinal tract: A paradise for acronims (STUMP, GIST, GANT andnow GIPACT), Implications of c.kiy in genesis, adn yet another of the many emerging roles of the interstitial cell of Cajal in the pathogenesis of gastrointestinal disease», Adv Anat Pathol , 6:19-40, 1999.36. Renshaw AA, Pinkus GS, Corson JM. «CD34 and AE1/AE3. Diagnostic discriminants in the distinction of solitary fibrous tumor of the pleura from sarcomatoid mesothelioma», Appl Immunohistochem , 2:94-102, 1994.37. Fletcher CDM. «Soft tissue tumours: an up-date. Recent Advances in Histopathology», Anthony PP, MacSween RNM , 15 Ed, pp 113-140, 1992.38. Ortiz-Hidalgo C, Baquera-Heredia J, Rojas-Reyna G, Craig R. «Solitary fobfous tumor of the carotid bifurcation clinically simulating a chemodectoma», Int J Surg Pathol , 6:223-228, 1998.39. Kutzner H. «Expression of the human progenitor cell antigen CD34 (HPCA-1) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalin-fixed, paraffin embedded tissue», J Am Acad Dermatol , 28:613-617, 1993.40. Haycox CL, Odland PB, Olbricht SM, Piepkorn M. «Immunohistochemical characterization of dermatofibrosarcoma protuberans with practical applications for diagnosis and treatment», JK Am Acad Dermatol , 37:438-444, 1997.41. Ruelas-Villaviciencio AL, Aponte Paredes PS, Ortiz-Hidalgo C. «Expresión de CD34 en el elastofibroma. Estudio clinicopatológico e inmunohistoquímico de 4 casos», Rev Invest Clin , 51:11-16, 1999.42. Scott FR, Rafaie A.El, More L, Scheuer PJ, Dhillon AP. «Hepatocellular carcinoma arising in an adenoma: value of QBend 10 immunostaining in diagnosis of liver cell carcinoma», Histopathology , 28:472-474, 1996.43. Zimmerman TM, Williams SF. Cytokines Cell Mol Ther, 4:257-264, 1998.
