1987-1993. Med Clin (Barc) 1999. En prensa. 17. Manson JE, Tosteson H, Ridker PM, Satterfield S, Herbert P, O\'connor GT, et al. The primary prevention of myocardial infarction. N Engl J Med 1992; 326: 1407-1416. 18. Rich-Edwards JW, Manson JE, Hennekens CH, Buring JE. The primary prevention of coronary heart disease in women. N Engl J Med 1995; 332: 1758-1766. 19. Maclure M. Demonstration of deductive meta-analysis: ethanol intake and risk of myocardial infarction. Epidemiol Rev 1993;1 5: 328-351. 20. Rimm EB, Klatsky A, Grobbee D, Stampfer MJ. Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits BMJ 1996; 312: 731-736. 21. Camargo CA Jr. Case-control and cohort studies of moderate alcohol consumption and stroke. Clin Chim Acta 1996; 246: 107-119. 7É3 22. Caicoya M, Rodríguez T, Corrales C, Cuello R, Lasheras C. Alcohol and stroke: a community case-control study in Asturias, Spain. J Clin Epidemiol 1999; 52: 677-684. 23. Lepp"l" JM, Paunio M, Virtamo J, Fogelholm R, Albanes D, Taylor PR, Heinonen OP. Alcohol consumption and stroke incidence in male smokers. Circulation 1999; 100: 1209- 1214. 24. Klatsky A. Blood pressure and alcohol intake. En: Laragh JH, Brenner BM, eds. Hypertension: pathophysiology, diagnosis, and management. 2¦ ed. Nueva York: Raven Press, 1995: 2649-2667. 25. Longnecker MP. Alcoholic beverage consumption in relation to risk of breast cancer: meta-analysis and review. Cancer Causes Control 1994; 5: 73-82. 26. Kune GA, Vitetta L. Alcohol consumption and the etiology of colorectal cancer: a review of the scientific evidence from 1957 to 1991. Nutr Cancer 1992; 18: 97-111. 27. Leino EV, Romelsj" A, Shoemaker C, Ager CR, Allebeck P, Ferrer HP, et al. Alcohol consumption and mortality. II. Studies of male populations. Addiction 1998; 93: 205-208. 28. Klatsky AL, Armstrong MA, Friedman GD. Alcohol and mortality. Ann Intern Med 1992; 117: 646-654. 29. Friedman GD, Klatsky AL. Is alcohol good for you health N Engl J Med 1993;329:1882-1883. 30. Pearson TA, Terry P. What to advise patients about drinking alcohol. The clinician\'s conundrum. JAMA 1994; 272: 967-968. 31. Jackson R, Beaglehole R. Alcohol consumption guidelines: relative safety vs absolute risks and benefits. Lancet 1995; 346: 716. 32. Pearson TA. Alcohol and heart disease. Circulation 1996; 94: 3023-3025. ******************************* (CUADRO 1; 22 FILAS × 5 COLUMNAS)(TITULO)Cuadro 1. Relación de la media y la mediana del consumo moderado de alcohol con la prevalencia de consumo excesivo en las 17 regiones de España, por sexo y tipo de bebida. Tomado de la cita 15. (TIPEADO POR FILAS)(1)MediaMediana(2)Definición de bebedor excesivo Coeficiente de correlación de Pearson (p) Coeficiente de regresión (95% CI)**Coeficiente de correlación de Pearson (p) Coeficiente de regresión (95% CI)**(3) Varones (unidades/semana [prevalencia]) 7É3 (4)Vino(5)>49 (10%)*0.74 (0.001)4.4 (2.2-6.6)0.84 (<0.001)1.3 (0.8-1.7) (6)>21 (12%)0.77 (0.001)6.8 (3.7-10.1)0.87 (<0.001)1.5 (1.0-1.9)(7)Cerveza(8)>12 (10%)*0.57 (0.016)5.0 (1.9-8.1)0.76 (<0.001)2.0 (1.1-3.0)(9)>21 (7%)0.61 (0.004)3.0 (0.6-5.4)0.68 (0.003)1.6 (0.7-2.5)(10)Espirituosas(11)>14 (10%)*0.45 (0.068)3.8 (-0.3-8.0)0.85 (<0.001)0.9 (0.6-1.2)(12)>21 (6%) 0.43 (0.086) 2.5 (0.4-5.4)0.87 (<0.001)0.8 (0.5-1.1)(13)Mujeres (unidades/semana [prevalencia])(14) 7É3 Vino(15)>5 (10%)*0.27 (0.298) 25.7 (-25.2-76.6)0.79 (<0.001)2.2 (1.3-3.1)(16)>14 (5%) 0.62 (0.007)8.8 (2.8-14.8)0.84 (<0.001)1.5 (1.0-2.1)(17)Cerveza (18)>2 (10%)*0.52 (0.032)53.4 (5.4-101.3)0.61 (0.009)4.2 (1.2-7-2)(19)>14 (1%)0.59 (0.016)1.5 (0.4-2.6)0.43 (0.083)0.4 (-0.5-0.9) (20)Espirituosas (21)>1 (10%)* 0.31 (0.225)98.4 (-67.1-263.9)0.36 (0.151)1.3 (-0.5-3.0) (22)>14 (1%) 0.43 (0.088)2.9 (-0.5-6.2) 0.77 (<0.001) 0.8 (0.4-1.2)(NOTA AL PIE DEL CUADRO)* Percentil 90 para cada sexo. Una unidad contiene 10 g de alcohol puro. ** Intervalos de confianza 95%******************************* 7É3
