José Manuel Fuentes Rodríguez *

Autor invitado por SIIC

Cambios en la actividad de diversas vías de transducción de señales producidas por concentraciones muy bajas del herbicida paraquat

EFECTOS DE BAJAS CONCENTRACIONES DE PARAQUAT SOBRE PKB, ERK Y JNK EN LAS NEURONAS

La exposición a bajas dosis de paraquat activa de una manera temprana las vías PKB, ERK y JNK. La inhibición de ésta última proteje las neuronas de los efectos tóxicos del paraquat.

*José Manuel Fuentes Rodríguez
describe para SIIC los aspectos relevantes de su trabajo
LOW CONCENTRATIONS OF PARAQUAT INDUCES EARLY ACTIVATION OF EXTRACELLULAR SIGNAL-REGULATED KINASE 1/2, PROTEIN KINASE B, AND C-JUN N-TERMINAL KINASE 1/2 PATHWAYS: ROLE OF C-JUN N-TERMINAL KINASE IN PARAQUAT-INDUCED CELL DEATH
Institución principal de la investigación
*Ciber de Enfermedades Neurodegenerativas, Cáceres, España
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González Polo RA, Rodríguez Martín A, Morán JM, Niso M, Soler G, Fuentes JM. Paraquat-induced apoptotic cell death in cerebellar granule cells. Brain Res 2004; 1011:170-176.
González Polo RA, Soler G, Alvarez A, Fabregat I, Fuentes JM. Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells. J Neurochem 2003; 84:305-315.
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Otros artículos de José Manuel Fuentes Rodríguez

Munder M, Schneider H, Luckner C, Giese T, Langhans CD, Fuentes JM, Kropf P Mueller I, Kolb A, Modolell M, Ho AD. Suppression of T-cell functions by human granulocyte arginase. Blood 2006; 108(5):1627-34.
Niso Santano M, Morán JM, García Rubio L, Gómez Martín A, González Polo RA, Soler G, Fuentes JM. Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death. Toxicol Sci 2006; 92(2):507-15.
Donaire V, Niso M, Moran JM, García L, González Polo RA, Soler G, Fuentes JM. Heat shock proteins protect both MPP(+) and paraquat neurotoxicity. Brain Res Bull 2005; 67(6):509-14. González Polo RA, Soler G, Fuentes JM. MPP+: mechanism for its toxicity in cerebellar granule cells. Mol Neurobiol 2004; 30(3):253-64.
González Polo RA, Soler G, Rodríguez Martín A, Morán JM, Fuentes JM. Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants. Cell Biol Int 2004; 28(5):373-80.
González Polo RA, Rodríguez Martín A, Morán JM, Niso M, Soler G, Fuentes JM. Paraquat-induced apoptotic cell death in cerebellar granule cells. Brain Res 2004; 1011(2):170-6.
González Polo RA, Soler G, Alonso JC, Rodríguez Martín A, Fuentes JM. MPP(+) causes inhibition of cellular energy supply in cerebellar granule cells. Neurotoxicology 2003; 24(2):219-25.
González Polo RA, Soler G, Alvarez A, Fabregat I, Fuentes JM. Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells. J Neurochem 2003; 84(2):305-15.
González Polo RA, Mora A, Clemente N, Sabio G, Centeno F, Soler G, Fuentes JM. Mechanisms of MPP(+) incorporation into cerebellar granule cells. Brain Res Bull 2001; 56(2):119-23.
Fuentes JM, Lompre AM, Moller JV, Falson P, Le Maire M. Clean Western blots of membrane proteins after yeast heterologous expression following a shortened version of the method of Perini et al. Anal Biochem 2000; 285(2):276-8.

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EFECTOS DE BAJAS CONCENTRACIONES DE PARAQUAT SOBRE PKB, ERK Y JNK EN LAS NEURONAS

Título original en castellano
INDUCCION TEMPRANA DE ERK1/2, PKB Y JNK1/2 POR BAJAS CONCENTRACIONES DE PARAQUAT. PAPEL DE JNK EN LA MUERTE NEURONAL INDUCIDA POR PARAQUAT

Autores
José Manuel Fuentes Rodríguez¹, Rosa Ana González Polo², José María Morán García³, Germán Soler Grau⁴, Mireia Niso Santano⁵, Miguel Angel Ortiz Ortiz⁶, Ana María Gómez Martin⁷
1 Profesor/investigador, Depto. Bioquimica y Biologia Molecular, Ciber de Enfermedades Neurodegenerativas, Cáceres, España, Catedrático
2 Investigadora, Ciber de Enfermedades Neurodegenerativas. Depto. Bioquimica y Biologia Molecular, Investigadora
3 Investigador, Ciber de Enfermedades Neurodegenerativas. Depto. Bioquimica y Biologia Molecular, Cáceres, España, Investigador
4 Profesor/investigador, Ciber de Enfermedades Neurodegenerativas. Depto. Bioquimica y Biologia Molecular, Catredrático
5 Investigadora, Ciber de Enfermedades Neurodegenerativas. Depto. Bioquimica y Biologia Molecular, Cáceres, España, Becario Predoctoral
6 Investigador, Ciber de Enfermedades Neurodegenerativas. Depto. Bioquimica y Biologia Molecular, Becario Predoctoral
7 Técnico, Ciber de Enfermedades Neurodegenerativas. Depto. Bioquimica y Biologia Molecular, Técnico de Apoyo a la Investigación

Acceso a la fuente original
Toxicological Sciences
http://www.toxsci.oupjournals.org

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