Eduardo Cabrera Rode *

Autor invitado por SIIC

El trabajo contribuye a conocer el efecto de la nicotinamida convencional en la prevención de la diabetes tipo 1 en familiares de primer grado de personas con diabetes tipo 1

EVALUACION DEL USO DE LA NICOTINAMIDA EN LA PREVENCION DE LA DIABETES TIPO 1

El ensayo controlado de intervención designado a prevenir el inicio clínico de diabetes tipo 1 fue factible, pero la nicotinamida convencional no fue eficaz en la prevención o retraso de la enfermedad a las dosis empleadas en este estudio.

*Eduardo Cabrera Rode
describe para SIIC los aspectos relevantes de su trabajo
EFFECT OF STANDARD NICOTINAMIDE IN THE PREVENTION OF TYPE 1 DIABETES IN FIRST DEGREE RELATIVES OF PERSONS WITH TYPE 1 DIABETES,
Institución principal de la investigación
*Instituto Nacional de Endocrinología, La Habana, Cuba
Imprimir nota

Referencias bibliográficas
1. Knip M, Akerblom HK. Environmental factors in the pathogenesis of type 1 diabetes mellitus. Exp Clin Endocrinol Diabetes 1999; 107(Suppl 3):S93-S100.
2. Hyoty H, Taylor KW. The role of viruses in human in human diabetes. Diabetologia 2002; 45:531-534.
3. Kulmala P, Savola K, Reijonen H, Veijola R, Vähäsalo P, Karjalainen J, Tuomilehto-Wolf E, Ilonen J, Tuomilehto J, Akerblom HK, Knip M and the Childhood Diabetes in Finland Study Group. Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group. Diabetes 2000, 49:48-58.
4. Krischer JP, Cuthbertson DD, Yu L, Orban T, Maclaren N, Jackson R, Winter WE, Schatz DA, Palmer JP, Eisenbarth GS. Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab 2003; 88:103-108.
5. Elliot RB, Chase HP. Prevention or delay of type (insulin-dependent) diabetes mellitus in children using nicotinamide. Diabetologia 1991; 34:362-65.
6. Elliot RB, Pilcher CC, Fergursson DM, Steward AW. A population based strategy to prevent insulin-dependent diabetes using nicotinamide. J Pediatr Endocrinol Metab 1996; 9:501-509.
7. The European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. Intervening before the onset of type 1 diabetes: baseline data from the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetologia 2003; 46:339-346.
8. Gale EA, Bingley PJ, Emmett CL, Collier T. European Nicotinamide Diabetes Intevention trial (ENDIT) Group. European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomized controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004; 363:925-931.
9. Beales PE, Burr LA, Webb GP, Mansfield KJ, Pozzilli P. Diet can influence the ability of nicotinamide to prevent diabetes in non-obese diabetic mouse: A preliminary study. Diabetes Metab Res Rev 1999; 15:21-28.
10. Devendra D, Liu E, Eisenbarth ES. Type 1 diabetes: recent developments. BMJ 2004; 328:750-754.

Otros artículos de Eduardo Cabrera Rode

Cabrera Rode E, Suárez Fonseca L, Díaz Horta O, Díaz O. New criteria for the classification of the diabetes mellitus. Rev Cubana Endocrinol 2000; 11:51-5.
Cabrera Rode E, Perich P, Díaz Horta O, Molina G, Suárez LR, Tiberti C, et al. Latent autoimmune diabetes in adult's (LADA) in type 2 diabetes: Frequency and characteristics. Rev Cubana Endocrinol 2001; 12:22-34.
Díaz Horta O, Bello M, Cabrera Rode E, Suárez J, Mas P, García I, et al. Echovirus 4 and type 1 diabetes mellitus. Autoimmunity 2001; 34:275-81.
Cabrera Rode E, Perich P, Díaz Horta O, Tiberti C, Molina G, Arranz C, et al. Slowly progressing type 1 diabetes: Persistence of islet cell autoantibodies is related to glibenclamide treatment. Autoimmunity 2002; 35:469-74.
Cabrera Rode E, Perich P, Licea M. Latent autoimmune diabetes in adults (LADA) or slowly progressing type 1 diabetes: Type 1 or type 1.5 diabetes? Revista de la Asociación Latinoamericana de Diabetes 2002; X:76-84.
Cabrera Rode E, Sarmiento L, Tiberti C, Molina G, Barrios J, Hernández D, et al. Type 1 diabetes islet associated antibodies in subjects infected by echovirus 16. Diabetologia 2003; 46:1348-53.
Sarmiento L, Cabrera Rode E, Díaz Horta O. Lack of association of latent autoimmune diabetes in adults (LADA) with enterovirus infection. Autoimmunity 2004; 37:245-246.
Cabrera Rode E, Sarmiento L, Molina G, Pérez C, Arranz C, Galvan JA, et al. Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic: a case report. J Med Virol 2005; 76:373-7.

Para comunicarse con Eduardo Cabrera Rode mencionar a SIIC como referencia:
diabetes@infomed.sld.cu

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Acerca del trabajo completo

EVALUACION DEL USO DE LA NICOTINAMIDA EN LA PREVENCION DE LA DIABETES TIPO 1