Marta Sampaio De Freitas *

Autora invitada por SIIC

EFEITO DA ALTERNAGINA-C SOBRE A MIGRAÇÃO E ATIVAÇÃO NEUTRÓFILOS

O trabalho contribui para uma melhor compreensão dos mecanismos de sinalização de integrinas em neutrófilos humanos.

*Marta Sampaio De Freitas
describe para SIIC los aspectos relevantes de su trabajo
ALTERNAGIN-C, A NONRGD-DISINTEGRIN, INDUCES NEUTROPHIL MIGRATION VIA INTEGRIN SIGNALING
Institución principal de la investigación
*Universidade Do Estado Do Rio de Janeiro - Instituto de Biologia - Departamento de Farmacologia, Rio de Janeiro, Brazil, Río de Janeiro, Brasil
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Referencias bibliográficas
[1] Brown, E.J. (1986) The interactions of connective tissue proteins with phagocytic cells. J. Leukoc. Biol. 39, 579-591.
[2] Lawrence, M.B. & Springer, T.A. (1991) Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins. Cell 65, 859-873.
[3] Berton, G., Yan, S.R., Fugamalli, L. & Lowell, C.A. (1996) Neutrophil activation by adhesion: Mechanisms and pathophysiological implications. Int. J. Clin. Lab. Res. 26, 160-177.
[4] Ruoslahti, E. (1991) Integrins. J. Clin. Invest. 87, 1-5.
[5] Hynes, R.O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
[6] Yamada, K.M. (1991) Adhesive recognition sequences. J. Biol. Chem. 266, 12809-12812.
[7] Burridge, K., Turner, C.E. & Romer L.H. (1992) Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J. Cell Biol. 119, 893-903.
[8] Kornberg, L., Earp, H.S., Parsons, J.T., Schaller, M. & Juliano, R.L. (1992) Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J. Biol. Chem. 267, 23439-23442.
[9] Parsons, J.T. (1996) Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins. Curr. Opin. Cell Biol. 8, 146-152.
[10] Löfgren, R., Ng-Sikorski, J., Sjölander A. & Andersson, T. (1993) b2-integrin engagement triggers actin polymerization and phosphatidylinositol triphosphate formation in non-adherent human neutrophils. J. Cell Biol. 123, 1597-1605.
[11] Miyamoto, S., Teramoto, H., Coso, O., Silvio, G., Burbelo, P., Akiyama, S.K. & Yamada, K.M. (1995) Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol. 131, 791-805.
[12] Zheng, L., Sjölander, A., Eckerdal, J. & Andersson, T. (1996) Antibody-induced engagement of b2-integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav. Proc. Natl. Acad. Sci. USA 93, 8431-8436.
[13] Dennis, M.S., Henzel, W.J., Pitti, R.M., Lipari, M.T., Napier, M.A., Deisher, T.A., Bunting, S. & Lazarus, R.A. (1990) Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: A family of integrin inhibitory proteins from viper venom. Proc. Natl. Acad. Sci. USA 87, 2471-2475.
[14] Gould, R.J., Polokoff, M.A., Fiedman, P.A., Huang, T-F., Holt, J.C., Cook, J.J. & Niewiarowski, S. (1990) Disintegrins: A family of integrin inhibitory proteins from viper venom. Proc. Soc. Exp. Biol. Med. 195, 168-171.
[15] Niewiarowski, S., McLane, M.A., Kloczwiak, M. & Stewart, G.J. (1994) Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors. Sem. Hematol. 31, 289-300.
[16] Juliano, D., Wang, Y., Marcinkiewicz, C., Rosenthal, A.L., Stewart, G.J. & Niewiarowski, S. (1996) Disintegrin interaction with avb3 integrin on human umbilical vein endothelial cells: expression of ligand-induced binding site on b3 subunit. Exp. Cell Res. 225, 132-142.
[17] Danen, E.H., Marcinkiewicz, C., Cornelissen, I.M., van Kraats, A.A., Pachter, J.A., Ruiter, J., Niewiarowski, S. & van Muijen, G.N. (1998) The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells. Exp. Cell Res. 238, 188-196.
[18] McLane, M.A., Marcinkiewicz, C., Vijay-Kumar, S., Wierzbicka-Patynowski, I, & Niewiarowski, S. (1998) Viper venom disintegrins and related molecules. Proc. Soc. Exp. Biol. Med. 219, 109-119.
[19] Coelho, A.L.J., De Freitas, M.S., Oliveira-Carvalho, A.L., Moura-Neto, V., Zingali, R.B. & Barja-Fidalgo, C. (1999) Effects of jarastatin, a novel snake venom disintegrin, on neutrophil migration and actin cytoskeleton dynamics. Exp. Cell Res. 251, 379-387.
[20] Coelho, A.L.J., De Freitas, M.S., Mariano-Oliveira, A., Oliveira-Carvalho, A.L., Zingali, R.B. & Barja-Fidalgo, C. (2001) Interaction of disintegrins with human neutrophils induces cytoskeleton reorganization, focal adhesion kinase activation and extracellular-regulated kinase-2 nuclear translocation, interfering with the chemotactic function. FASEB J. 15, 1643-1645.
[21] Souza, D.H.F., Iemma, M.R.C., Ferreira, L.L., Faria, J.P., Oliva, M.L.V., Zingali, R.B., Niewiarowski, S. & Selistre-de-Araujo, H.S. (2000) The disintegrin-like domain of the snake venom metalloprotease alternagin inhibits a2b1 integrin-mediated cell adhesion. Arch. Biochem. Biophys. 384, 341-350.
[22] Dooley, D.C., Simpson, J.F. & Merryman, H.T. (1982) Isolation of large numbers of fully viable human neutrophils: A preparative technique using Percoll density gradient centrifugation. Exp. Hematol. 10, 591-599.
[23] Bradford, M. (1976) A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
[24] Sheikh, S., Gratzer, W.B., Pinder, J.C. & Nash, G.B. (1997) Actin polymerization regulates integrin-mediated adhesion as well as rigidity of neutrophils. Bioch. Biophys. Res. Commun. 238, 910-915.
[25] Chen, H.C. & Guan, J.L. (1994) Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 91, 10148-10152.
[26] Toker, A. & Cantley, L.C. (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387, 673-676.
[27] Klemke, R.L., Cai, S., Giannini, A.L., Gallagher, P.J., de Lanerolle, P. & Cheresh, D.A. (1997) Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137, 481-492.
[28] Jia, L-G., Wang, X-M., Shannon, J.D., Bjarnasson, J.B. & Fox, J.W. (1997) Function of disintegrin-like/cysteine-rich domains of atrolysin A. Inhibition of platelet aggregation by recombinant protein and peptide antagonists. J. Biol. Chem. 272, 13094-13102.
[29] Stanton, K.J., Frewin, M.B. & Gudewicz, P.W. (1999) Heterologous desensitization of IL-8-mediated chemotaxis in human neutrophils by a cell-binding fragment of fibronectin. J. Leukoc. Biol. 65, 515-522.
[30] Williams, M.A. & Solonkin, J.S. (1999) Integrin-mediated signaling in human neutrophil functioning. J. Leukoc. Biol. 65, 725-735.
[31] Schwartz, M.A. (2001) Integrin signaling revisited. TRENDS Cell Biol. 11, 466-470.
[32] Gaudry, M., Caon, A.C., Gilbert, C., Lille, S. & Naccache, P.H. (1992) Evidence for the involvement of tyrosine kinases in the locomotory responses of human neutrophils. J. Leukoc. Biol. 51, 103-108.
[33] McGregor, P.E., Agrawal, D.K. & Edwards, J.D. (1994) Attenuation of human leukocyte adherence to endothelial cell monolayers by tyrosine kinase inhibitors. Biochem. Biophys. Res. Commun. 198, 359-365.
[34] Huang, M.-M., Lipfert, L., Cunningham, M., Brugge, J.S., Ginsberg, M.H & Shattil, S.J. (1993) Adhesive ligand binding to integrin aIIby3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J. Cell Biol. 122, 473-483.
[35] S. Bhattacharya, C. Fu, J. Bhattacharya, S. Greenberg, S. Soluble ligands of the avb3 integrin mediate enhanced tyrosine phosphorylation of multiple proteins in adherent bovine pulmonary artery endothelial cells. J. Biol. Chem. 270 (1995) 16781-16787.
[36] Bryan Smith, J., Theakston, R.D.G., Coelho, A.L.J., Barja-Fidalgo, C., Calvete, J.J. & Marcinkiewicz, C. (2002) Characterization of a monomeric disintegrin, ocellatusin, present in the venom of the Nigerian carpet viper, Echis ocellatus. FEBS Lett. 512, 111-115.
[37] Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M. & Yamamoto, T. (1995) Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-44.
[38] Feniger-Barish, R., Yron, H., Meshel, T., Matityahu, E. & Ben-Baruch, A. (2003) Il-8-induced migratory responses thrugh CXCR1 and CXCR2: Association with phosphorylation and cellular redistribution of focal adhesion kinase. Biochem. 42, 2874-2886.
[39] Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A.V. & Wu, D. (2000) Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287, 1046-1049.
[40] Hirsch, E., Katanaev, V.L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F. & Wymann, M.P. (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287, 1049-1053.
[41] Coffer, P.J., Geijsen, M., M´rabet, L., Schweizer, R.C., Maikoe, T., Raaijmakers, J.A., Lammers, J.W. & Koenderman, L. (1998) Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. Biochem. J. 329, 121-130.
[42] Ritter, M.R. & Markland F.S.Jr. (2000) Contortrostatin activates ERK2 and tyrosine phosphorylation events via distinct pathways. Biochem. Biophys. Res. Commun. 274, 142-148.