Alexandre De Paula Rogerio *

Autor invitado por SIIC

O trabalho contribui (El trabajo contribuye) para que a quercetina possa ser (pueda ser) utilizada futuramente em ensaios clínicos ou mesmo no (o aun para el) tratamento de pacientes com asma.

TRATAMENTO DE PACIENTES COM ASMA

A quercetina demonstra potencial de reduzir os mais (reducir los más) significativos fenótipos da asma (recrutamento de eosinófilos e neutrófilos, produção de muco e de (de moco y de) hiperatividade das vias aéreas). Estes resultados sugerem que a quercetina, pode ser utilizada medicinalmente ou mesmo como complemento de outros fármacos para o tratamento de asma.

*Alexandre De Paula Rogerio
describe para SIIC los aspectos relevantes de su trabajo
QUERCETIN: A FLAVONOID WITH THE POTENTIAL TO TREAT ASTHMA
Institución principal de la investigación
*Universidade Federal Do Triângulo Mineiro, Uberaba, Brasil
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Referencias bibliográficas
Calixto JB, Beirith A, Ferreira J, Santos AR, Filho VC, Yunes RA. Naturally occurring antinociceptive substances from plants. Phytother Res 14(6):401-418, 2000.
Calixto JB, Campos MM, Otuki MF, Santos AR. Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med 69(2):973-983, 2004.
De Boer VC, Dihal AA, Van der Woude H, Arts IC, Wolffram GM, Alink GM, Rietjens IM, Keijer J, Hollman PC. Tissue distribution of quercetin in rats and pigs. J Nutr 135(7):1718-1725, 2005.
Fortunato LR, Alves CF, Teixeira MM, Rogerio AP. Quercetin: a flavonoid with the potential to treat asthma. Braz J Pharm Sci 48(4):589-599, 2012.
Middleton E, Chithan K, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52(4):673-751, 2000.
Mukherjee AB, Zhang Z. Allergic asthma: influence of genetic and environmental factors. J Biol Chem 286(38):32883-32889, 2011.
Papiris SA, Manali ED, Kolilekas L, Triantafillidou C, Tsangaris I. Acute severe asthma: new approaches to assessment and treatment. Drugs 69(17):2363-2391, 2009.
Potterat O, Hamburger M. Drug discovery and development with plant-derived compounds. Prog Drug Res 65(45):47-118, 2008.
Rainsford KD. Anti-inflammatory drugs in the 21st century. Subcell Biochem 42:3-27, 2007.
Rogerio AP, Dora CL, Andrade EL, Chaves JS, Silva LF, Lemos-Senna E, Calixto JB. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol Res 61(4):288-297, 2010. Rogerio, A.P, Fontanari, C, Borducchi, E, Keller, A.C, Russo, M., Soares, E.G, Albuquerque, D.A, Faccioli, L.H. Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma. Eur J Pharmacol, v.580, n.1-2, p.262-70, 2008., L.H. Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid. J Pharm Pharmacol, v.58, n.9, p.1265-1273, 2006.
Rogerio AP, Kanashiro A, Fontanari C, Da Silva EV, Lucisano-Valim YM, Soares EG, Facioli LH. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res 56(10):402-408, 2007.
Rogerio AP, Sa-Nunes A, Albuquerque DA, Anibal FF, Medeiros AI, Machado ER, Souza AO, Prado JC Jr, Faccioli LH. Lafoensia pacari extract inhibits IL-5 production in toxocariasis. Parasite Immunol 25(7):393-400, 2003.
Rogerio AP, Sá-Nunes A, Faccioli LH. The activity of medicinal plants and secondary metabolites on eosinophilic inflammation. Pharmacol Res 62(4):298-307, 2010.
Sircar G, Saha B, Bhattacharya SG, Saha S. Allergic asthma biomarkers using systems approaches. Front Genet 8(4):308, 2014.
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Walle T, Walle UK, Halushka PV. Carbon dioxide is the major metabolite of quercetin in humans. J Nutr 131(10):2648-2652, 2001.

Otros artículos de Alexandre De Paula Rogerio

Rogerio AP, Sa-Nunes A, Albuquerque DA, Anibal FF, Medeiros AI, Machado ER, Souza AO, Prado JC Jr, Faccioli LH. Lafoensia pacari extract inhibits IL-5 production in toxocariasis. Parasite Immunology 25:393-400, 2003.
Rogerio AP, Fontanari C, Melo MC, Ambrosio SR, De Souza GE, Pereira PS, Franca SC, Da Costa FB, Albuquerque DA, Faccioli LH. Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid. Jounal of Pharmacy and Pharmacology 58:1265-1273, 2006.
Rogerio AP, Cardoso CR, Fontanari C, Souza MA, Afonso-Cardoso SR, Silva EV, Koyama NS, Basei FL, Soares EG, Calixto JB, Stowell SR, Dias-Baruffi M, Faccioli LH. Anti-asthmatic potential of a D-galactose-binding lectin from Synadenium carinatum latex. Glycobiology 17:795-804, 2007.
Rogerio AP, Kanashiro A, Fontanari C, Da Silva EVG, Lucisano-Valim YM, Soares EG, Faccioli LH. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflammation Research 56:402-408, 2007.
Rogerio AP, Fontanari C, Borducchi E, Keller AC, Russo M, Soares EG, Albuquerque DA, Faccioli LH. Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma. European Journal of Pharmacology 580:262-270, 2008.
Rogerio AP, Andrade EL, Leite DFP, Figueiredo CP, Calixto JB. Preventive and therapeutic anti-inflammatory properties of the sesquiterpene and alpha-humulene in experimental airways allergic inflammatory model. British Journal of Pharmacology 158:1074-1087, 2009.
Rogerio AP, Dora CL, Andrade EL, Chaves JS, Silva LFC, Lemos-Senna E, Calixto, JB . Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacological Research 61:288-297, 2010.
Rogerio AP, Nunes AS, Faccioli, LH. The activity of medicinal plants and secondary metabolites on eosinophilic inflammation. Pharmacological Research 68:298-307, 2010.
Rogerio AP, Haworth O, Croze R, Oh SF, Uddin M, Carlo T, Pfeffer MA, Priluck R, Serhan CN, Levy BD. Resolvin D1 and aspirin-triggered resolvin d1 promote resolution of allergic airways responses. J Immunol 189:1983-91, 2012.
Cornélio Favarin D, Martins Teixeira M, Lemos de Andrade E, De Freitas Alves C, Lazo Chica JE, Artério Sorgi C, Faccioli LH, Paula Rogerio A. Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice. Mediators Inflamm, 2013.

Para comunicarse con Alexandre De Paula Rogerio mencionar a SIIC como referencia:
alexprogerio@biomedicina.uftm.

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Acerca del trabajo completo

TRATAMENTO DE PACIENTES COM ASMA

Título original en castellano
QUERCETINA: UM FLAVONOIDE COM POTENCIAL PARA TRATAR A ASMA

Autores
Alexandre De Paula Rogerio¹, Laila Rigolin Fortunato², Claudiney De Freitas Alves³, Maxelle Martins Teixeira⁴
1 Farmacêutico, Universidade Federal Do Triângulo Mineiro, Uberaba, Brasil, Professor
2 Medica, Universidade Federal Do Triangulo Mineiro
3 Biomédico, Universidade Federal Do Triangulo Mineiro
4 Biomédica, Universidade Federal Do Triangulo Mineiro

Acceso a la fuente original
Brazilian Journal of Pharmaceutical Sciences
http://www.scielo.br/scielo.php?script=sci_serial&pid=1984-8250&nrm=iso&rep=&lng=pt

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