Ana M Aransay *

Autor invitado por SIIC

Esta investigación ha sido posible gracias a la colaboración de varias instituciones internacionales coordinadas por los proyectos HEPADIP y CIBERehd

EL PAPEL DEL TRANSPORTADOR SLC2A1 EN LA PATOGENIA DEL HÍGADO GRASO

A partir de un estudio de asociación de variantes genéticas, un consorcio internacional de investigadores relacionó ciertas mutaciones en el gen del transportador Glut1 (SLC2A1) con la aparición de enfermedad de hígado graso y demostró que la inhibición de este gen incrementa el almacenamiento de grasa en hepatocitos.

*Ana M Aransay
describe para SIIC los aspectos relevantes de su trabajo
SOLUTE CARRIER FAMILY 2 MEMBER 1 IS INVOLVED IN THE DEVELOPMENT OF NONALCOHOLIC FATTY LIVER DISEASE
Institución principal de la investigación
*Cic Biogune, Derio, España
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Otros artículos de Ana M Aransay

Martínez-Chantar M.L., Vázquez-Chantada M., Ariz U., Martínez N., Varela M., Luka Z., Capdevila A., Rodríguez J., Aransay A.M., Matthiesen R., Yang H., Calvisi D. F., Esteller M., Fraga M., Lu S.C., Wagner C. and Mato J.M. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology 47(4): 119 –1199 (2008)

Hackenberg, M., Sturm, M., Langenberger, D., Falcón-Pérez, J.M. and Aransay, A.M. miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments. REF. REVISTA/LIBRO: Nucleic Acids Research 37, Supp.2 (Web Server issue): W68-W76 (2009)

Rodríguez-Ezpeleta, N., Álvarez-Busto, J., Imaz L, Regueiro, M.,•Azcárate, M.N., Bilbao R., Iriondo, M., Gil A., Estonba A. and•Aransay, A.M. High-density SNP genotyping detects homogeneity of Spanish and French Basques, and confirms their genomic distinctiveness from other European populations. Human Genetics 128(1): 113 – 117 (2010).

Díaz-Peña R., Aransay A.M., Bruges-Armas J., López-Vázquez A., Rodríguez-Ezpeleta N., Mendibil I., Sánchez A., Torre-Alonso J.C., Bettencourt B.F., Mulero J., Collantes E. and López-Larrea C. Fine mapping of major histocompatibility complex in ankylosing spondylitis: association of HLA-DPA1 and HLA-DPB1 region. Arthritis & Rheumatism 63(11):3305-12 (2011)

Rodriguez-Ezpeleta N., Hackenberg M. and Aransay A.M. Bioinformatics for High Throughput Sequencing. Springer, New York, NY, USA, (2012) (Hardcover: ISBN 978-1-4614-0781-2; eBook: SBN 978-1-4614-0782-9). http://dx.doi.org/10.1007/978-1-4614-0782-9, (Book edition and Chapter)

Vandenbroeck K., Alvarez J., Swaminathan B., Alloza I., Matesanz F., Urcelay E., Comabella M., Alcina A., Fedetz M., Ortiz M.A., Izquierdo G., Fernandez O., Rodriguez-Ezpeleta N., Matute C., Caillier S., Arroyo R., Montalban X., Oksenberg J.R., Antigüedad A., Aransay A. A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis. Genes and Immunity 13:21-28 (2012)

Díaz-Peña R., Aransay A.M., Suárez-Álvarez B., Bruges-Armas J., Rodríguez-Ezpeleta N., Regueiro M., Pimentel-Santos F.M., Mulero J., Sánchez A., Collantes E., Queiro R., Ballina J., Alves H. and López-Larrea C. A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis. Ann Rheum Dis 71:714-717 (2012)

Mercedes Vazquez-Chantada, Aintzane Gonzalez-Lahera, Ibon Martinez-Arranz, Carmelo Garcia-Monzon, Manuela Maria Regueiro, Juan Luis Garcia-Rodriguez, Karin Anna Schlangen, Iñaki Mendibil, Naiara Rodriguez-Ezpeleta, Juan Jose Lozano, Karina Banasik, Johanne M Justesen, Torben Joergensen, Daniel R Witte, Torsten Lauritzen, Torben Hansen, Oluf Pedersen, Nicolas Veyrie, Karine Clement, Joan Tordjman, Albert Tran, Yannik Le Marchand-Brustel, Xabier Buque, Patricia Aspichueta, Jose Javier Echevarria-Uraga, Antonio Martin-Duce, Joan Caballería, Philippe Gual, Azucena Castro, Jose M Mato, Maria Luz Martinez-Chantar, Ana Maria Aransay. Solute carrier family 2 member 1 (SLC2A1) is involved in the development of Non-Alcoholic Fatty Liver Disease. Hepatology 57(2): 505-514 (2013)

Mosén-Ansorena & Aransay A.M. Bivariate segmentation of SNP-array data for allele-specific copy number analysis in tumour samples. BMC Bioinformatics 14: 84 (2013)

Felix Royo, Karin Schlangen, Laura Palomo, Esperanza Gonzalez, Javier Conde- Vancells, Agustin Berisa, Ana M. Aransay and Juan M. Falcon-Perez
TITULO: Transcriptome of extracellular vesicles released by hepatocytes
REF. REVISTA/LIBRO: PLosONE (PONE-D-13-10983R1, In press 2013)

Para comunicarse con Ana M Aransay mencionar a SIIC como referencia:
amaransay@cicbiogune.es

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Acerca del trabajo completo

EL PAPEL DEL TRANSPORTADOR SLC2A1 EN LA PATOGENIA DEL HÍGADO GRASO

Título original en castellano
EL GEN SLC2A1 (SOLUTE CARRIER FAMILY 2 MEMBER1) ESTA IMPLICADO EN EL DESARROLLO DE LA ENFERMEDAD DE HIGADO GRASO NO ALCOHOLICO

Autor
Ana M Aransay¹
1 Investigador, Cic Biogune, Derio, España, Responsable de Plataforma Tecnológica

Acceso a la fuente original
Hepatology
http://www3.interscience.wiley.com/cgi-bin/jhome/106570044

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