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Danilo Roman-Campos describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo ALVOS TERAPÊUTICOS CONTRA A DISFUNÇÃO CARDIACA NA DOENÇA DE CHAGAS Chagas disease, which is caused by the parasite Trypanosoma cruzi, is an important cause of heart failure. We investigated modifications in the cellular electrophysiological and calcium-handling characteristics of an infected mouse heart during the chronic phase of the disease. The patch-clamp technique was used to record action potentials (APs) and L-type Ca2+ and transient outward K+ currents. [Ca2+]i changes were determined using confocal microscopy. Infected ventricular cells showed prolonged APs, reduced transient outward K+ and L-type Ca2+ currents and reduced Ca2+ release from the sarcoplasmic reticulum. Thus, the chronic phase of Chagas disease is characterised by cardiomyocyte dysfunction, which could lead to heart failure. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación , BH-MG, Brasil  Authors' Report Crónica del Autor Bibliographic references Referencias bibliográficas Novel insights into the development of chagasic cardiomyopathy: Role of PI3Kinase/NO axis. Roman-Campos D, Sales-Junior P, Duarte HL, Gomes ER, Lara A, Campos P, Rocha NN, Resende RR, Ferreira A, Guatimosim S, Gazzinelli RT, Ropert C, Cruz JS. Int J Cardiol. 2012 Sep 29. doi:pii: S0167-5273(12)01126-6 Other articles written by the author Danilo Roman-Campos Otros artículos de Danilo Roman-Campos A novel channelopathy in pulmonary arterial hypertension. Roman-Campos D, Ma L,Austin ED, Eyries M, Sampson KS, Soubrier F, Germain M, Trégouët DA, Borczuk A, Rosenzweig EB, Girerd B, Montani D, Humbert M, Loyd JE, Kass RS, Chung WK. N Engl J Med. 2013 Jul 25;369(4):351-61; Cardiomyocyte dysfunction during the chronic phase of Chagas disease. Roman-Campos D, Sales-Júnior P, Duarte HL, Gomes ER, Guatimosim S, Ropert C, Gazzinelli RT, Cruz JS. Mem Inst Oswaldo Cruz. 2013 Apr;108(2):243-5. Novel insights into the development of chagasic cardiomyopathy: Role of PI3Kinase/NO axis. Roman-Campos D, Sales-Junior P, Duarte HL, Gomes ER, Lara A, Campos P, Rocha NN, Resende RR, Ferreira A, Guatimosim S, Gazzinelli RT, Ropert C, Cruz JS. Int J Cardiol. 2012 Sep 29. doi:pii: S0167-5273(12)01126-6; Changes in cellular contractility and cytokines profile during Trypanosoma cruzi infection in mice. Roman-Campos D, Duarte HL, Sales PA Jr, Natali AJ, Ropert C, Gazzinelli RT, Cruz JS. Basic Res Cardiol. 2009 May;104(3):238-46; Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease. Esper L, Roman-Campos D, Lara A, Brant F, Castro LL, Barroso A, Araujo RR, Vieira LQ, Mukherjee S, Gomes ER, Rocha NN, Ramos IP, Lisanti MP, Campos CF, Arantes RM, Guatimosim S, Weiss LM, Cruz JS, Tanowitz HB, Teixeira MM, Machado FS. Am J Pathol. 2012 Jul;181(1):130-40 Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway. Cunha TM, Roman-Campos D, Lotufo CM, Duarte HL, Souza GR, Verri WA Jr, Funez MI, Dias QM, Schivo IR, Domingues AC, Sachs D, Chiavegatto S, Teixeira MM, Hothersall JS, Cruz JS, Cunha FQ, Ferreira SH. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4442-7. SIIC System of Assisted Editing (SSEA) / Sistema SIIC de Edición Asistida (SSEA)
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Information about the full text Acerca del trabajo completo Cardiomyocyte Dysfunction During the Chronic Phase of Chagas Disease Author / Autor Danilo Roman-Campos1 1 Researcher, Faculdade de Medicina de Ribeirão Preto, Av Bandeirantes 3900, Ribeirão Preto, Brasil, Postdoctoral Researcher Access to the original source Memorias do Instituto Oswaldo Cruz siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |
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