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Aurelio Pio Nardozza describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo REACTIVE OXYGEN SPECIES CONTROL SHP-2 DIMERIZATION AND ACTIVITY SHP-2 dimerization is stabilized by the formation of disulfide bonds and it is modulated by growth factors and by the cellular redox state. Notably, the dimeric form is less active compared to its the monomeric self-inhibited counterpart pointing to dimerization as an additional mechanism to control SHP-2 activity. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación University of Rome Tor Vergata, Rome, Rome, Italy  Authors' Report Crónica del Autor Bibliographic references Referencias bibliográficas Adler V, Yin Z, Tew KD, Ronai Z. Role of redox potential and reactive oxygen species in stress signaling. Oncogene 18:6104-6111, 1999. Benezra R. An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures. Cell 79:1057-1067, 1994. Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, et al. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res 64:8816-8820, 2004. Dance M, Montagner A, Salles JP, Yart A, Raynal P. The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway. Cell Signal 20:453-459, 2008. Finkel T. Oxygen radicals and signaling. Curr Opin Cell Biol 10:248-253, 1998. Huang Q, Lerner-Marmarosh N, Che W, Ohta S, Osawa M, Yoshizumi M, et al. The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation. J Biol Chem 277:29330-29341, 2002. Legius E, Schrander-Stumpel C, Schollen E, Pulles-Heintzberger C, Gewillig M, Fryns JP. PTPN11 mutations in LEOPARD syndrome. J Med Genet 39:571-574, 2002. Lesage F, Reyes R, Fink M, Duprat F, Guillemare E, Lazdunski M. Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge. EMBO J 15:6400-6407, 1996. Martinelli S, Nardozza AP, Delle Vigne S, Sabetta G, Torreri P, Bocchinfuso G, et al. Counteracting effects operating on Src-homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome. J Biol Chem 287(32):27066-27077, 2012. Martinelli S, Torreri P, Tinti M, Stella L, Bocchinfuso G, Flex E, et al. Diverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromes. Hum Mol Genet 17:2018-2029, 2008. Meng TC, Fukada T, Tonks NK. Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 9:387-399, 2002. Mesecke N, Terziyska N, Kozany C, Baumann F, Neupert W, Hell K, Herrmann JM. A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Cell 121:1059-1069, 2005. Tartaglia M, Martinelli S, Stella L, Bocchinfuso G, Flex E, Cordeddu V, et al. Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. Am J Hum Genet 78:279-290, 2006. Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, et al. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet 29:465-468, 2001. Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 34:148-150, 2003. SIIC System of Assisted Editing (SSEA) / Sistema SIIC de Edición Asistida (SSEA)
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Information about the full text Acerca del trabajo completo Reactive Oxygen Species and Epidermal Growth Factor Are Antagonistic Cues Controlling SHP-2 Dimerization Author / Autor Aurelio Pio Nardozza1, Melania D'orazio2, Riccardo Trapannone3, Salvatore Corallino4, Giuseppe Filomeni5, Marco Tartaglia6, Andrea Battistoni7, Gianni Cesareni8, Luisa Castagnoli9 9, University Of Rome Tor Vergata Access to the original source Molecular and Cellular Biology Article URL: / URL del artículo: http://mcb.asm.org/ URL of Abstract: / URL del abstract: http://mcb.asm.org/search?fulltext=nardozza&submit=yes&x=0&y=0 URL of Abstract page in Medline: / URL del abstract en Medline: http://www.ncbi.nlm.nih.gov/pubmed/22411627 siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |
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