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Amit K Gupta describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo Pharmacophore modelling, for EGFR tyrosine kinase inhibitors PHARMACOPHORE MODELLING, MOLECULAR DOCKING AND VIRTUAL SCREENING FOR EGFR (HER 1) TYROSINE KINASE INHIBITORS A pharmacophore model has been developed using diverse classes of epidermal growth factor receptor (EGFR) inhibitors to design and discover novel EGFR tyrosine kinase inhibitors. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación Central Drug Research Institute, Lucknow, Uttar Pradesh  Authors' Report Crónica del Autor Bibliographic references Referencias bibliográficas Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon EA. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol Cell 11:507-517, 2003. Gundla R, Kazemi R, Sanam R, Muttineni R, Sarma AJ, Dayam R, Neamati N. Discovery of novel small-molecule inhibitors of human epidermal growth factor receptor-2: Combined ligand and target-based approach. J Med Chem 51:3367-3377, 2008. Guy CT, Cardiff RD, Muller WJ. Activated neu induces rapid tumor progression. J Biol Chem 271:7673-7678, 1996. Jordan JD, Landau EM, Iyengar R. Signaling networks: The origins of cellular Multitasking. Cell 103:193-200, 2000. Kim SG, Yoon CJ, Kim SH, Cho YJ, Kang DI. Building a common feature hypothesis for thymidylate synthase inhibition. Bioorg Med Chem 8:11-17, 2000. Li H, Sutter J, Hoffmann R. HypoGen: An Automated System for Generating 3D Predictive Pharmacophore Models. In Pharmacophore Perception, Development and Use in Drug Design, International University Line, La Jolla, CA; 2000. Lin R, Johnson SG, Connolly PJ, Wetter SK, Binnun E, Hughes TV, Murray WV, Pandey NV, Moreno-Mazza SJ, Adams M, Fuentes-Pesquera AR. Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Bioorg Med Chem Lett 19:2333-2337, 2009. Motta CL, Sartini S, Tuccinardi T, Nerini E, Da Settimo F, Martinelli A. Computational studies of epidermal growth factor receptor: Docking reliability, three-dimensional quantitative structure-activity relationship analysis, and virtual screening studies. J Med Chem52:964-975, 2009. Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem 274:17209-17218, 1999. Olayioye MA, Neve RM, Lane HA, Hynes NE. The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J 19:3159-3167, 2000. Pannala M, Kher S, Wilson N, Gaudette J, Sircar I, Zhang S, et al. Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett 17:5978-5982, 2007. Other articles written by the author Amit K Gupta Otros artículos de Amit K Gupta Pharmacophore Modeling of Substituted 1,2,4-Trioxanes for Quantitative Prediction of their Antimalarial Activity, Amit K. Gupta, S. Chakroborty, Kumkum Srivastava, Sunil K. Puri, and Anil K. Saxena, J. Chem. Inf. Model. 2010, 50, 1510–1520. Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum, Amit K. Gupta, Shruti Saxena, Mridula Saxena, Bioorg. Med. Chem. Lett. 2010, 20, 4779–4781. Toward the Identification of a Reliable 3D QSAR Pharmacophore Model for the CCK2 Receptor Antagonism, Amit K. Gupta, Kanika Varshney, and Anil K. Saxena, J. Chem. Inf. Model. 2012, 52, 1376–1390. Identification of Novel S-Adenosyl-L-Homocysteine Hydrolase Inhibitors through Homology-Model-Based Virtual Screening, Synthesis, and Biological Evaluation, Prashant Khare, Amit K. Gupta, Praveen K. Gajula, Krishna Y. Sunkari, Anil K. Jaiswal, Sanchita Das, Preeti Bajpai,Tushar K. Chakraborty, Anuradha Dube, and Anil K. Saxena, Chem. Inf. Model. 2012, 52, 777-791. SIIC System of Assisted Editing (SSEA) / Sistema SIIC de Edición Asistida (SSEA)
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Information about the full text Acerca del trabajo completo Pharmacophore Modelling, Molecular Docking and Virtual Screening for EGFR (HER 1) Tyrosine Kinase Inhibitors Author / Autor SS Bhunia1, VW Balaramnavar2, AK Saxena3 3 Mr., Medicinal And Process Chemistry Division, Central Drug Research Institute, Csir, Lucknow, India, Lucknow, India, Senior Research Fellow Article URL: / URL del artículo: http://www.tandf.co.uk/journals/titles/1062936x.html URL of Abstract page in Medline: / URL del abstract en Medline: http://www.ncbi.nlm.nih.gov/pubmed/21400356 siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |
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